Leonard Shultz to Mutation
This is a "connection" page, showing publications Leonard Shultz has written about Mutation.
Connection Strength
1.796
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Hosur V, Cox ML, Burzenski LM, Riding RL, Alley L, Lyons BL, Kavirayani A, Martin KA, Cox GA, Johnson KR, Shultz LD. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice. PLoS One. 2013; 8(1):e53426.
Score: 0.232
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Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010 Feb 11; 115(6):1267-76.
Score: 0.186
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Shultz LD, Lyons BL, Burzenski LM, Gott B, Samuels R, Schweitzer PA, Dreger C, Herrmann H, Kalscheuer V, Olins AL, Olins DE, Sperling K, Hoffmann K. Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Hu?t anomaly. Hum Mol Genet. 2003 Jan 01; 12(1):61-9.
Score: 0.116
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Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F. Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways. Sci Transl Med. 2017 Oct 25; 9(413).
Score: 0.081
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Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ. Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice. Exp Hematol. 2017 04; 48:41-49.
Score: 0.077
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Hasgur S, Aryee KE, Shultz LD, Greiner DL, Brehm MA. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells. Methods Mol Biol. 2016; 1438:67-78.
Score: 0.071
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Pelsue SC, Schweitzer PA, Beamer WG, Shultz LD. Mapping of the flaky skin (fsn) mutation on distal mouse chromosome 17. Mamm Genome. 1995 Oct; 6(10):758.
Score: 0.070
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Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2200-9.
Score: 0.064
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Hosur V, Kavirayani A, Riefler J, Carney LM, Lyons B, Gott B, Cox GA, Shultz LD. Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma. Cancer Genet. 2012 May; 205(5):232-41.
Score: 0.055
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Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes. 2010 Sep; 59(9):2265-70.
Score: 0.049
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Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL. A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008 Aug; 51(8):1449-56.
Score: 0.042
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King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. 2008 Mar; 126(3):303-14.
Score: 0.041
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Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007 Jul; 8(5):416-21.
Score: 0.039
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Shultz LD. Pleiotropic mutations causing abnormalities in the murine immune system and the skin. Curr Probl Dermatol. 1987; 17:236-50.
Score: 0.038
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Tezuka H, Inoue T, Noguti T, Kada T, Shultz LD. Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effects. Mutat Res. 1986 Jun; 161(1):83-90.
Score: 0.037
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Outzen HC, Corrow D, Shultz LD. Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation. J Natl Cancer Inst. 1985 Nov; 75(5):917-23.
Score: 0.035
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Helms C, Pelsue S, Cao L, Lamb E, Loffredo B, Taillon-Miller P, Herrin B, Burzenski LM, Gott B, Lyons BL, Keppler D, Shultz LD, Bowcock AM. The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia. Exp Biol Med (Maywood). 2005 Oct; 230(9):659-67.
Score: 0.035
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Shultz LD, Coman DR, Bailey CL, Beamer WG, Sidman CL. "Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol. 1984 Aug; 116(2):179-92.
Score: 0.032
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Hoffmann K, Dreger CK, Olins AL, Olins DE, Shultz LD, Lucke B, Karl H, Kaps R, M?ller D, Vay? A, Aznar J, Ware RE, Sotelo Cruz N, Lindner TH, Herrmann H, Reis A, Sperling K. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Hu?t anomaly). Nat Genet. 2002 Aug; 31(4):410-4.
Score: 0.028
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Shultz LD, Sweet HO, Davisson MT, Coman DR. 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia. Nature. 1982 Jun 03; 297(5865):402-4.
Score: 0.028
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Nystuen A, Legare ME, Shultz LD, Frankel WN. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron. 2001 Oct 25; 32(2):203-12.
Score: 0.027
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Hsu HC, Shultz LD, Su X, Shi J, Yang PA, Relyea MJ, Zhang HG, Mountz JD. Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice. J Immunol. 2001 Jan 15; 166(2):772-80.
Score: 0.025
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Hosur V, Low BE, Li D, Stafford GA, Kohar V, Shultz LD, Wiles MV. Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation. Genome Biol. 2020 07 09; 21(1):168.
Score: 0.024
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Umeda S, Beamer WG, Takagi K, Naito M, Hayashi S, Yonemitsu H, Yi T, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol. 1999 Jul; 155(1):223-33.
Score: 0.023
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Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency. Mol Ther. 2017 11 01; 25(11):2477-2489.
Score: 0.020
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Shultz LD, Rajan TV, Greiner DL. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997 Aug; 15(8):302-7.
Score: 0.020
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Cheng F, Twardowski L, Reifenberg K, Winter K, Canisius A, Pross E, Fan J, Schmitt E, Shultz LD, Lackner KJ, Torzewski M. Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice. PLoS One. 2016; 11(8):e0157311.
Score: 0.019
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Shultz LD, Green MC. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol. 1976 Apr; 116(4):936-43.
Score: 0.018
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Araki M, Fukumatsu Y, Katabuchi H, Shultz LD, Takahashi K, Okamura H. Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. Biol Reprod. 1996 Feb; 54(2):478-84.
Score: 0.018
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Green MC, Shultz LD. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered. 1975 Sep-Oct; 66(5):250-8.
Score: 0.017
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Beamer WG, Shultz KL, Tennent BJ, Shultz LD. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res. 1993 Aug 15; 53(16):3741-6.
Score: 0.015
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Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 1993 Jul 02; 73(7):1445-54.
Score: 0.015
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Seymour R, Shirley BJ, Hogenesch H, Shultz LD, Sundberg JP. Loss of function of the mouse Sharpin gene results in Peyer's patch regression. PLoS One. 2013; 8(2):e55224.
Score: 0.015
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Disney JE, Barth AL, Shultz LD. Defective repair of radiation-induced chromosomal damage in scid/scid mice. Cytogenet Cell Genet. 1992; 59(1):39-44.
Score: 0.014
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Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R. Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice. Pancreas. 2011 Oct; 40(7):1147-9.
Score: 0.013
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Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23; 18(9):1189-98.
Score: 0.013
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Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
Score: 0.013
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Sundberg JP, Beamer WG, Shultz LD, Dunstan RW. Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses. J Invest Dermatol. 1990 Nov; 95(5 Suppl):62S-63S.
Score: 0.012
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Sprecher E, Becker Y, Kraal G, Hall E, Shultz LD. Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J mice. Arch Dermatol Res. 1990; 282(3):188-93.
Score: 0.012
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Willis EH, Carson DA, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Adv Exp Med Biol. 1989; 253B:209-12.
Score: 0.011
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Bosma GC, Davisson MT, Ruetsch NR, Sweet HO, Shultz LD, Bosma MJ. The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics. 1989; 29(1):54-7.
Score: 0.011
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Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15028-33.
Score: 0.011
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Shultz LD. Pleiotropic effects of deleterious alleles at the "motheaten" locus. Curr Top Microbiol Immunol. 1988; 137:216-22.
Score: 0.010
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Willis EH, Carson DA, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Biochem Biophys Res Commun. 1987 May 29; 145(1):581-5.
Score: 0.010
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Leiter EH, Prochazka M, Shultz LD. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol. 1987 May 15; 138(10):3224-9.
Score: 0.010
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Clark EA, Shultz LD, Pollack SB. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics. 1981 Mar 01; 12(5-6):601-13.
Score: 0.006
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Myint YY, Miyakawa K, Naito M, Shultz LD, Oike Y, Yamamura K, Takahashi K. Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. Am J Pathol. 1999 Feb; 154(2):553-66.
Score: 0.006
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Sidman CL, Shultz LD, Unanue ER. The mouse mutant "motheaten". I. Development of lymphocyte populations. J Immunol. 1978 Dec; 121(6):2392-8.
Score: 0.005
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Sidman CL, Shultz LD, Unanue ER. The mouse mutant "motheaten." II. Functional studies of the immune system. J Immunol. 1978 Dec; 121(6):2399-404.
Score: 0.005
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Miyamoto A, Kunisada T, Yamazaki H, Miyake K, Nishikawa SI, Sudo T, Shultz LD, Hayashi SI. Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase. Immunol Lett. 1998 Sep; 63(2):75-82.
Score: 0.005
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Westhoff CM, Whittier A, Kathol S, McHugh J, Zajicek C, Shultz LD, Wylie DE. DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance. J Immunol. 1997 Sep 15; 159(6):3024-33.
Score: 0.005
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Green MC, Shultz LD, Nedzi LA. Abnormal nuclear morphology of leukocytes in the mouse mutant ichthyosis. Transplantation. 1975 Aug; 20(2):172-5.
Score: 0.004
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Leiter EH, Beamer WG, Shultz LD, Barker JE, Lane PW. Mouse models of genetic diseases. Birth Defects Orig Artic Ser. 1987; 23(3):221-57.
Score: 0.002
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Johnson DA, Shultz LD, Bedigian HG. Immunodeficiency and reticulum cell sarcoma in mice segregating for HRS/J and SJL/J genes. Leuk Res. 1982; 6(5):711-20.
Score: 0.002