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Juleen Zierath to Humans

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This is a "connection" page, showing publications Juleen Zierath has written about Humans.
Juleen Zierath
Connection Strength
1.778
Humans
  1. Rizo-Roca D, Henderson JD, Zierath JR. Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes. J Intern Med. 2025 Jun; 297(6):584-607.
    View in: PubMed
    Score: 0.036
  2. Katayama M, Nomura K, Mudry JM, Chibalin AV, Krook A, Zierath JR. Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle. Mol Metab. 2025 Feb; 92:102081.
    View in: PubMed
    Score: 0.035
  3. Zierath JR, van der Velden J, Javaheri A, Rosenzweig A, Muoio DM, Mulvihill EE, Martino TA, Rasheed A, Chen XW, Arany ZP. Translating metabolic and cardiovascular research into effective treatments: What's next? Cell. 2024 Jul 25; 187(15):3880-3884.
    View in: PubMed
    Score: 0.034
  4. Jollet M, Tramontana F, Jiang LQ, Borg ML, Savikj M, Kuefner MS, Massart J, de Castro Barbosa T, Manner?s-Holm L, Checa A, Pillon NJ, Chibalin AV, Bj?rnholm M, Zierath JR. Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity. Metabolism. 2024 Sep; 158:155939.
    View in: PubMed
    Score: 0.034
  5. Richter EA, James DE, Kirwan JP, Zierath JR. Exploratory physiological experiments are not clinical trials. Cell Metab. 2024 May 07; 36(5):882-883.
    View in: PubMed
    Score: 0.034
  6. Ashcroft SP, Stocks B, Egan B, Zierath JR. Exercise induces tissue-specific adaptations to enhance cardiometabolic health. Cell Metab. 2024 02 06; 36(2):278-300.
    View in: PubMed
    Score: 0.033
  7. Pillon NJ, Sard?n Puig L, Altintas A, Kamble PG, Casan?-Gald?n S, Gabriel BM, Barr?s R, Conesa A, Chibalin AV, N?slund E, Krook A, Zierath JR. Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers. Life Sci Alliance. 2023 01; 6(1).
    View in: PubMed
    Score: 0.030
  8. Pillon NJ, Smith JAB, Alm PS, Chibalin AV, Alhusen J, Arner E, Carninci P, Fritz T, Otten J, Olsson T, van Doorslaer de Ten Ryen S, Deldicque L, Caidahl K, Wallberg-Henriksson H, Krook A, Zierath JR. Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. Sci Adv. 2022 09 09; 8(36):eabo3192.
    View in: PubMed
    Score: 0.030
  9. Stocks B, Zierath JR. Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity. Endocr Rev. 2022 07 13; 43(4):654-677.
    View in: PubMed
    Score: 0.030
  10. Kanaley JA, Colberg SR, Corcoran MH, Malin SK, Rodriguez NR, Crespo CJ, Kirwan JP, Zierath JR. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2022 02 01; 54(2):353-368.
    View in: PubMed
    Score: 0.029
  11. Sj?gren RJO, Rizo-Roca D, Chibalin AV, Chorell E, Furrer R, Katayama S, Harada J, Karlsson HKR, Handschin C, Moritz T, Krook A, N?slund E, Zierath JR. Branched-chain amino acid metabolism is regulated by ERRa in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia. 2021 09; 64(9):2077-2091.
    View in: PubMed
    Score: 0.028
  12. Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell. 2021 03 18; 184(6):1530-1544.
    View in: PubMed
    Score: 0.027
  13. Karlsson HKR, Kasahara A, Ikeda M, Chibalin AV, Harada J, Ryd?n M, Krook A, Kato M, Kubota K, Zierath JR. Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study. Metabolism. 2021 05; 118:154726.
    View in: PubMed
    Score: 0.027
  14. Dollet L, Pendergrast LA, Zierath JR. The role of the molecular circadian clock in human energy homeostasis. Curr Opin Lipidol. 2021 Feb 01; 32(1):16-23.
    View in: PubMed
    Score: 0.027
  15. Hawley JA, Sassone-Corsi P, Zierath JR. Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men. Diabetologia. 2020 11; 63(11):2253-2259.
    View in: PubMed
    Score: 0.026
  16. Savikj M, Zierath JR. Train like an athlete: applying exercise interventions to manage type 2 diabetes. Diabetologia. 2020 08; 63(8):1491-1499.
    View in: PubMed
    Score: 0.026
  17. Pillon NJ, Gabriel BM, Dollet L, Smith JAB, Sard?n Puig L, Botella J, Bishop DJ, Krook A, Zierath JR. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020 01 24; 11(1):470.
    View in: PubMed
    Score: 0.025
  18. Zierath JR. Major Advances and Discoveries in Diabetes - 2019 in Review. Curr Diab Rep. 2019 11 04; 19(11):118.
    View in: PubMed
    Score: 0.025
  19. Sardon Puig L, Pillon NJ, N?slund E, Krook A, Zierath JR. Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression. Am J Physiol Endocrinol Metab. 2020 01 01; 318(1):E1-E10.
    View in: PubMed
    Score: 0.025
  20. Massart J, Zierath JR. Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis. Trends Endocrinol Metab. 2019 09; 30(9):603-617.
    View in: PubMed
    Score: 0.024
  21. Borg ML, Massart J, Sch?nke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR. Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice. Diabetes. 2019 07; 68(7):1403-1414.
    View in: PubMed
    Score: 0.024
  22. Gabriel BM, Zierath JR. Circadian rhythms and exercise - re-setting the clock in metabolic disease. Nat Rev Endocrinol. 2019 04; 15(4):197-206.
    View in: PubMed
    Score: 0.024
  23. Dollet L, Zierath JR. Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue. J Physiol. 2019 03; 597(6):1439-1450.
    View in: PubMed
    Score: 0.023
  24. Lassiter DG, Sj?gren RJO, Gabriel BM, Krook A, Zierath JR. AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. Mol Metab. 2018 10; 16:12-23.
    View in: PubMed
    Score: 0.023
  25. Lassiter DG, Nyl?n C, Sj?gren RJO, Chibalin AV, Wallberg-Henriksson H, N?slund E, Krook A, Zierath JR. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. Diabetologia. 2018 02; 61(2):424-432.
    View in: PubMed
    Score: 0.021
  26. Ruby MA, Riedl I, Massart J, ?hlin M, Zierath JR. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017 10 01; 313(4):E483-E491.
    View in: PubMed
    Score: 0.021
  27. Gabriel BM, Zierath JR. The Limits of Exercise Physiology: From Performance to Health. Cell Metab. 2017 May 02; 25(5):1000-1011.
    View in: PubMed
    Score: 0.021
  28. Ruby MA, Massart J, Hunerdosse DM, Sch?nke M, Correia JC, Louie SM, Ruas JL, N?slund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017 01 17; 18(3):636-646.
    View in: PubMed
    Score: 0.020
  29. Mudry JM, Lassiter DG, Nyl?n C, Garc?a-Calz?n S, N?slund E, Krook A, Zierath JR. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2017 03; 66(3):651-662.
    View in: PubMed
    Score: 0.020
  30. Egan B, Hawley JA, Zierath JR. SnapShot: Exercise Metabolism. Cell Metab. 2016 08 09; 24(2):342-342.e1.
    View in: PubMed
    Score: 0.020
  31. Barr?s R, Zierath JR. The role of diet and exercise in the transgenerational epigenetic landscape of T2DM. Nat Rev Endocrinol. 2016 08; 12(8):441-51.
    View in: PubMed
    Score: 0.020
  32. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 06 14; 23(6):1034-1047.
    View in: PubMed
    Score: 0.020
  33. Zierath JR. Turning the page. Diabetologia. 2015 Dec; 58(12):2685-7.
    View in: PubMed
    Score: 0.019
  34. Zierath JR. Diabetologia at 50: celebrating half a century of progress in diabetes research and care. Diabetologia. 2015 Aug; 58(8):1685-7.
    View in: PubMed
    Score: 0.018
  35. Zierath JR, Wallberg-Henriksson H. Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us? Cell Metab. 2015 Jul 07; 22(1):25-30.
    View in: PubMed
    Score: 0.018
  36. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 06; 159(4):738-49.
    View in: PubMed
    Score: 0.017
  37. Al-Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta PG, Osler ME, Katayama M, Nystr?m AC, Oscarsson J, Zierath JR. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C774-87.
    View in: PubMed
    Score: 0.017
  38. Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1408-14.
    View in: PubMed
    Score: 0.016
  39. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, N?slund E, Zierath JR. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013 Apr 25; 3(4):1020-7.
    View in: PubMed
    Score: 0.016
  40. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 05; 17(2):162-84.
    View in: PubMed
    Score: 0.015
  41. Kirchner H, Osler ME, Krook A, Zierath JR. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 2013 May; 23(5):203-9.
    View in: PubMed
    Score: 0.015
  42. Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb; 62(2):457-65.
    View in: PubMed
    Score: 0.015
  43. Barr?s R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 07; 15(3):405-11.
    View in: PubMed
    Score: 0.015
  44. Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 07; 286(40):34567-74.
    View in: PubMed
    Score: 0.014
  45. Barres R, Zierath JR. DNA methylation in metabolic disorders. Am J Clin Nutr. 2011 Apr; 93(4):897S-900.
    View in: PubMed
    Score: 0.013
  46. Zierath JR, Krook A. [Molecular mechanisms underlying insulin resistance in skeletal muscle]. Lakartidningen. 2010 Nov 10-16; 107(45):2802-5.
    View in: PubMed
    Score: 0.013
  47. Barr?s R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 2009 Sep; 10(3):189-98.
    View in: PubMed
    Score: 0.012
  48. Wallberg-Henriksson H, Zierath JR. A new twist on brown fat metabolism. Cell. 2009 Apr 03; 137(1):22-4.
    View in: PubMed
    Score: 0.012
  49. Long YC, Zierath JR. Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E545-52.
    View in: PubMed
    Score: 0.011
  50. Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes. 2008 Jun; 57(6):1508-16.
    View in: PubMed
    Score: 0.011
  51. Chibalin AV, Leng Y, Vieira E, Krook A, Bj?rnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nyl?n C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008 Feb 08; 132(3):375-86.
    View in: PubMed
    Score: 0.011
  52. Osler ME, Zierath JR. Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology. 2008 Mar; 149(3):935-41.
    View in: PubMed
    Score: 0.011
  53. Zierath JR. The path to insulin resistance: paved with ceramides? Cell Metab. 2007 Mar; 5(3):161-3.
    View in: PubMed
    Score: 0.010
  54. Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem. 2007 Mar 16; 282(11):7783-9.
    View in: PubMed
    Score: 0.010
  55. Karlsson HK, Zierath JR. Insulin signaling and glucose transport in insulin resistant human skeletal muscle. Cell Biochem Biophys. 2007; 48(2-3):103-13.
    View in: PubMed
    Score: 0.010
  56. Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 2006 Jul; 4(1):89-96.
    View in: PubMed
    Score: 0.010
  57. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006 Jul; 116(7):1776-83.
    View in: PubMed
    Score: 0.010
  58. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes. 2006 Jun; 55(6):1776-82.
    View in: PubMed
    Score: 0.010
  59. Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR. IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients. Diabetes. 2006 Mar; 55(3):785-91.
    View in: PubMed
    Score: 0.010
  60. Hawley JA, Hargreaves M, Zierath JR. Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation. Essays Biochem. 2006; 42:1-12.
    View in: PubMed
    Score: 0.009
  61. Barnes BR, Long YC, Steiler TL, Leng Y, Galuska D, Wojtaszewski JF, Andersson L, Zierath JR. Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. Diabetes. 2005 Dec; 54(12):3484-9.
    View in: PubMed
    Score: 0.009
  62. Sen I, Smith JAB, Caria E, Orlov I, Savikj M, Brady AJ, Lian K, Ellefsen S, Zierath JR, Krook A. Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis. Sci Adv. 2025 Jul 11; 11(28):eads4371.
    View in: PubMed
    Score: 0.009
  63. Smith JAB, Gabriel BM, Brady AJ, Abdelmoez AM, Savikj M, Wright SC, Koutsilieri S, Barr?s R, Lauschke VM, Krook A, Zierath JR, Pillon NJ. Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis. Mol Metab. 2025 Sep; 99:102200.
    View in: PubMed
    Score: 0.009
  64. Keller MJ, Brady AJ, Smith JAB, Savikj M, MacGregor K, Jollet M, ?berg SB, Nyl?n C, Bj?rnholm M, Rickenlund A, Carlsson M, Caidahl K, Krook A, Pillon NJ, Zierath JR, Wallberg-Henriksson H. Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes. Diabetologia. 2025 Sep; 68(9):2023-2035.
    View in: PubMed
    Score: 0.009
  65. Kj?rgaard J, Lindqvist CB, Quesada JP, Jessen S, Schlabs F, Ehrlich AM, Yonamine CY, Garc?a-Ure?a M, Schmalbruch JH, Small L, Thomassen M, Lemminger AK, Eibye K, Gonzalez-Franquesa A, Stidsen JV, H?jlund K, Zierath JR, Kilpel?inen TO, Bangsbo J, Treebak JT, Hostrup M, Deshmukh AS. Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake. Cell Rep Med. 2025 Jun 17; 6(6):102163.
    View in: PubMed
    Score: 0.009
  66. Kj?rgaard J, Stocks B, Henderson J, Freemantle JB, Rizo-Roca D, Puglia M, Madrazo Montoya M, Andersson D, B?ckdahl J, Eriksson-Hogling D, Stidsen JV, Wierer M, Rasmussen S, Sakamoto K, H?jlund K, Ryd?n M, Zierath JR, Krook A, Deshmukh AS. Personalized molecular signatures of insulin resistance and type 2 diabetes. Cell. 2025 Jul 24; 188(15):4106-4122.e16.
    View in: PubMed
    Score: 0.009
  67. Karlsson HK, H?llsten K, Bj?rnholm M, Tsuchida H, Chibalin AV, Virtanen KA, Heinonen OJ, L?nnqvist F, Nuutila P, Zierath JR. Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes. 2005 May; 54(5):1459-67.
    View in: PubMed
    Score: 0.009
  68. Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev. 2005 May; 1(2):167-74.
    View in: PubMed
    Score: 0.009
  69. Zierath JR. Kinases in diabetes. Part I. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):118-20.
    View in: PubMed
    Score: 0.009
  70. Zierath JR. Kinases in diabetes. Part II. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):121-3.
    View in: PubMed
    Score: 0.009
  71. Stocks B, Quesada JP, Mozzicato AM, Jacob C, Jensen S, MacGregor KA, Bangsbo J, Zierath JR, Hostrup M, Deshmukh AS. Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise. Sci Adv. 2025 Jan 31; 11(5):eadp8608.
    View in: PubMed
    Score: 0.009
  72. Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 Oct; 2(10):e348.
    View in: PubMed
    Score: 0.009
  73. Rizo-Roca D, Guimar?es DSPSF, Pendergrast LA, Di Leo N, Chibalin AV, Maqdasy S, Ryd?n M, N?slund E, Zierath JR, Krook A. Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes. Sci Transl Med. 2024 10 09; 16(768):eado3022.
    View in: PubMed
    Score: 0.009
  74. Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine LM, Higos R, Jalkanen J, Zhong J, Zareifi DS, Frendo-Cumbo S, Massier L, Hodek O, Juvany M, Moritz T, de Castro Barbosa T, Omar-Hmeadi M, L?pez-Yus M, Merabtene F, Abatan JB, Marcelin G, El Hachem EJ, Rouault C, Bergo MO, Petrus P, Zierath JR, Cl?ment K, Krook A, Mejhert N, Ryd?n M. Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Nat Metab. 2024 Jul; 6(7):1329-1346.
    View in: PubMed
    Score: 0.009
  75. Krook A, Wallberg-Henriksson H, Zierath JR. Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc. 2004 Jul; 36(7):1212-7.
    View in: PubMed
    Score: 0.009
  76. Nomura K, Kinoshita S, Mizusaki N, Senga Y, Sasaki T, Kitamura T, Sakaue H, Emi A, Hosooka T, Matsuo M, Okamura H, Amo T, Wolf AM, Kamimura N, Ohta S, Itoh T, Hayashi Y, Kiyonari H, Krook A, Zierath JR, Kasuga M, Ogawa W. Adaptive gene expression of alternative splicing variants of PGC-1a regulates whole-body energy metabolism. Mol Metab. 2024 Aug; 86:101968.
    View in: PubMed
    Score: 0.009
  77. Leng Y, Karlsson HK, Zierath JR. Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord. 2004 May; 5(2):111-7.
    View in: PubMed
    Score: 0.008
  78. Long YC, Widegren U, Zierath JR. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc. 2004 May; 63(2):227-32.
    View in: PubMed
    Score: 0.008
  79. Guimar?es DSPSF, Barrios NMF, de Oliveira AG, Rizo-Roca D, Jollet M, Smith JAB, Araujo TR, da Cruz MV, Marconato E, Hirabara SM, Vieira AS, Krook A, Zierath JR, Silveira LR. Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6. J Cachexia Sarcopenia Muscle. 2024 Aug; 15(4):1335-1347.
    View in: PubMed
    Score: 0.008
  80. Koistinen HA, Forsgren M, Wallberg-Henriksson H, Zierath JR. Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects. Obes Res. 2004 Jan; 12(1):25-31.
    View in: PubMed
    Score: 0.008
  81. Hawley JA, Zierath JR. Integration of metabolic and mitogenic signal transduction in skeletal muscle. Exerc Sport Sci Rev. 2004 Jan; 32(1):4-8.
    View in: PubMed
    Score: 0.008
  82. Dollet L, Lundell LS, Chibalin AV, Pendergrast LA, Pillon NJ, Lansbury EL, Elmastas M, Frendo-Cumbo S, Jalkanen J, de Castro Barbosa T, Cervone DT, Caidahl K, Dmytriyeva O, Deshmukh AS, Barr?s R, Ryd?n M, Wallberg-Henriksson H, Zierath JR, Krook A. Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M. Cell Rep Med. 2024 01 16; 5(1):101348.
    View in: PubMed
    Score: 0.008
  83. Zierath JR, Kawano Y. The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle. Best Pract Res Clin Endocrinol Metab. 2003 Sep; 17(3):385-98.
    View in: PubMed
    Score: 0.008
  84. Kemppainen J, Tsuchida H, Stolen K, Karlsson H, Bj?rnholm M, Heinonen OJ, Nuutila P, Krook A, Knuuti J, Zierath JR. Insulin signalling and resistance in patients with chronic heart failure. J Physiol. 2003 Jul 01; 550(Pt 1):305-15.
    View in: PubMed
    Score: 0.008
  85. Yu M, Stepto NK, Chibalin AV, Fryer LG, Carling D, Krook A, Hawley JA, Zierath JR. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol. 2003 Jan 15; 546(Pt 2):327-35.
    View in: PubMed
    Score: 0.008
  86. Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder M. Reply to 'Lactate as a major myokine and exerkine'. Nat Rev Endocrinol. 2022 11; 18(11):713.
    View in: PubMed
    Score: 0.008
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  96. Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Bj?rnholm M, J?rgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS. Discovery of thymosin ?4 as a human exerkine and growth factor. Am J Physiol Cell Physiol. 2021 11 01; 321(5):C770-C778.
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  97. Williams K, Carrasquilla GD, Ingerslev LR, Hochreuter MY, Hansson S, Pillon NJ, Donkin I, Versteyhe S, Zierath JR, Kilpel?inen TO, Barr?s R. Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health. Mol Metab. 2021 11; 53:101290.
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  98. Smith JAB, Savikj M, Sethi P, Platt S, Gabriel BM, Hawley JA, Dunstan D, Krook A, Zierath JR, N?slund E. Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity. Am J Physiol Endocrinol Metab. 2021 08 01; 321(2):E203-E216.
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  99. Gonzalez-Franquesa A, Stocks B, Chubanava S, Hattel HB, Moreno-Justicia R, Peijs L, Treebak JT, Zierath JR, Deshmukh AS. Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity. Cell Rep. 2021 05 25; 35(8):109180.
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  100. Tessier CM, Kokkinos A, Mingrone G, Koliaki C, Zierath JR, Mantzoros CS. COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic. Metabolism. 2021 06; 119:154769.
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  101. Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Altintas A, Sato S, Sassone-Corsi P, Barr?s R, Zierath JR, Hawley JA. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020 09 16; 11(1):4643.
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  102. Brand?o BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL, Branquinho JL, Razolli D, Pinto S, Nielsen TS, Festuccia WT, Martins AS, Guerra BA, Knittel TL, S?gaard D, Larsen S, Helge JW, Brandauer J, Velloso LA, Emanuelli B, Kornfeld JW, Kahn CR, Vienberg SG, Zierath JR, Treebak JT, Mori MA. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23932-23941.
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  103. Batista TM, Jayavelu AK, Wewer Albrechtsen NJ, Iovino S, Lebastchi J, Pan H, Dreyfuss JM, Krook A, Zierath JR, Mann M, Kahn CR. A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. Cell Metab. 2020 11 03; 32(5):844-859.e5.
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  105. Katayama M, Wiklander OPB, Fritz T, Caidahl K, El-Andaloussi S, Zierath JR, Krook A. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019 03; 68(3):515-526.
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  108. Mashili FL, Ramaiya K, Lutale J, Njelekela M, Francis F, Zierath J, Krook A. Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus. J Obes. 2018; 2018:7461903.
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  110. Savikj M, Ruby MA, Kostovski E, Iversen PO, Zierath JR, Krook A, Widegren U. Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals. Physiol Rep. 2018 06; 6(12):e13739.
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  123. Ring M, Eriksson MJ, Zierath JR, Caidahl K. Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques. Hypertens Res. 2014 Nov; 37(11):999-1007.
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  124. Massart J, Zierath JR, Chibalin AV. A simple and rapid method to characterize lipid fate in skeletal muscle. BMC Res Notes. 2014 Jun 24; 7:391.
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  130. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Fr?sig C, Leick L, Fentz J, J?rgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20.
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  135. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev. 2011 Mar; 27(3):286-97.
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  137. Czepluch FS, Barr?s R, Caidahl K, Olieslagers S, Krook A, Rickenlund A, Zierath JR, Waltenberger J. Strenuous physical exercise adversely affects monocyte chemotaxis. Thromb Haemost. 2011 Jan; 105(1):122-30.
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  138. Feng X, Yan J, Wang Y, Zierath JR, Nordenskj?ld M, Henter JI, Fadeel B, Zheng C. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol. 2010 Aug; 47(14):2388-96.
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  139. Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010 May 15; 588(Pt 10):1779-90.
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  140. Benziane B, Bj?rnholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1554-66.
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  141. Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD. Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes. 2009 Apr; 58(4):847-54.
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  142. Kuoppamaa H, Skrobuk P, Sihvo M, Hiukka A, Chibalin AV, Zierath JR, Koistinen HA. Globular adiponectin stimulates glucose transport in type 2 diabetic muscle. Diabetes Metab Res Rev. 2008 Oct; 24(7):554-62.
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  143. Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1427-38.
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  144. Cabrera O, Jacques-Silva MC, Speier S, Yang SN, K?hler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metab. 2008 Jun; 7(6):545-54.
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  145. Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes. 2008 Aug; 57(8):2066-73.
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  146. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Bj?rnholm M, Tornqvist H, Zierath JR, Ridderstr?le M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med. 2007 May; 4(5):e158.
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  147. Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A. Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes. 2007 Jun; 56(6):1630-7.
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  148. Fritz T, Kr?mer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A. Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev. 2006 Nov-Dec; 22(6):492-8.
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  149. Karlsson HK, Ahls?n M, Zierath JR, Wallberg-Henriksson H, Koistinen HA. Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes. 2006 May; 55(5):1283-8.
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  150. Coffey VG, Zhong Z, Shield A, Canny BJ, Chibalin AV, Zierath JR, Hawley JA. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J. 2006 Jan; 20(1):190-2.
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  151. Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK. Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes. 2005 Oct; 54(10):2939-45.
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  152. Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palac?n M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes. 2005 Sep; 54(9):2685-93.
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  153. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun; 54(6):1692-7.
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    Score: 0.002
  154. Kr?mer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR, Krook A. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005 Apr; 54(4):1157-63.
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    Score: 0.002
  155. Al-Khalili L, Krook A, Zierath JR, Cartee GD. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab. 2004 Sep; 287(3):E553-7.
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    Score: 0.002
  156. Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E1-7.
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    Score: 0.002
  157. Storgaard H, Jensen CB, Bj?rnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA. Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab. 2004 Mar; 89(3):1301-11.
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    Score: 0.002
  158. Al-Khalili L, Chibalin AV, Yu M, Sj?din B, Nyl?n C, Zierath JR, Krook A. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1410-6.
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    Score: 0.002
  159. Perrini S, Henriksson J, Zierath JR, Widegren U. Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle. Diabetes. 2004 Jan; 53(1):21-4.
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    Score: 0.002
  160. Mahlapuu M, Johansson C, Lindgren K, Hj?lm G, Barnes BR, Krook A, Zierath JR, Andersson L, Marklund S. Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E194-200.
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    Score: 0.002
  161. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes. 2003 May; 52(5):1066-72.
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    Score: 0.002
  162. Isaksson B, Str?mmer L, Friess H, B?chler MW, Herrington MK, Wang F, Zierath JR, Wallberg-Henriksson H, Larsson J, Permert J. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. Pancreas. 2003 Mar; 26(2):173-7.
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    Score: 0.002
  163. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR, Rabasa-Lhoret R, Wallberg-Henriksson H, Laville M, Palac?n M, Vidal H, Rivera F, Brand M, Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem. 2003 May 09; 278(19):17190-7.
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    Score: 0.002
  164. Tsuchida H, Bj?rnholm M, Fernstr?m M, Galuska D, Johansson P, Wallberg-Henriksson H, Zierath JR, Lake S, Krook A. Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects. Pflugers Arch. 2002 Oct; 445(1):25-31.
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    Score: 0.002
  165. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J. 2002 Aug; 16(10):1163-76.
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    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.