Kenneth Rock to Histocompatibility Antigens Class I
This is a "connection" page, showing publications Kenneth Rock has written about Histocompatibility Antigens Class I.
Connection Strength
12.777
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Cruz FM, Orellano LAA, Chan A, Rock KL. Alternate MHC I Antigen Presentation Pathways Allow CD8+ T-cell Recognition and Killing of Cancer Cells in the Absence of ?2M or TAP. Cancer Immunol Res. 2025 Jan 09; 13(1):98-108.
Score: 0.853
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Colbert JD, Cruz FM, Baer CE, Rock KL. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Proc Natl Acad Sci U S A. 2022 10 18; 119(42):e2122188119.
Score: 0.730
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Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation. Front Immunol. 2021; 12:636568.
Score: 0.654
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Colbert JD, Rock KL. How a tailor achieves the perfect fit. J Biol Chem. 2020 05 22; 295(21):7211-7212.
Score: 0.618
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Colbert JD, Cruz FM, Rock KL. Cross-presentation of exogenous antigens on MHC I molecules. Curr Opin Immunol. 2020 06; 64:1-8.
Score: 0.603
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Cruz FM, Colbert JD, Rock KL. The GTPase Rab39a promotes phagosome maturation into MHC-I antigen-presenting compartments. EMBO J. 2020 01 15; 39(2):e102020.
Score: 0.600
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Kriegsman BA, Vangala P, Chen BJ, Meraner P, Brass AL, Garber M, Rock KL. Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression. J Immunol. 2019 10 01; 203(7):1999-2010.
Score: 0.588
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Rock KL, Reits E, Neefjes J. Present Yourself! By MHC Class I and MHC Class II Molecules. Trends Immunol. 2016 11; 37(11):724-737.
Score: 0.478
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Rock KL, Farf?n-Arribas DJ, Colbert JD, Goldberg AL. Re-examining class-I presentation and the DRiP hypothesis. Trends Immunol. 2014 Apr; 35(4):144-52.
Score: 0.401
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Colbert JD, Farf?n-Arribas DJ, Rock KL. Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I. J Immunol. 2013 Dec 01; 191(11):5410-9.
Score: 0.393
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Kincaid EZ, Che JW, York I, Escobar H, Reyes-Vargas E, Delgado JC, Welsh RM, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rock KL. Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol. 2011 Dec 25; 13(2):129-35.
Score: 0.345
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Kawahara M, York IA, Hearn A, Farfan D, Rock KL. Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo. J Immunol. 2009 Nov 15; 183(10):6069-77.
Score: 0.297
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Hearn A, York IA, Rock KL. The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum. J Immunol. 2009 Nov 01; 183(9):5526-36.
Score: 0.297
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Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL. Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol. 2008 Feb 01; 180(3):1704-12.
Score: 0.264
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Rock KL. Exiting the outside world for cross-presentation. Immunity. 2006 Oct; 25(4):523-5.
Score: 0.240
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Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL. Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation. J Immunol. 2005 Nov 15; 175(10):6605-14.
Score: 0.226
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Shen L, Sigal LJ, Boes M, Rock KL. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity. 2004 Aug; 21(2):155-65.
Score: 0.207
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Rock KL, York IA, Goldberg AL. Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004 Jul; 5(7):670-7.
Score: 0.206
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Rock KL. The ins and outs of cross-presentation. Nat Immunol. 2003 Oct; 4(10):941-3.
Score: 0.195
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Sari G, Rock KL. Tumor immune evasion through?loss of MHC class-I antigen presentation. Curr Opin Immunol. 2023 08; 83:102329.
Score: 0.190
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York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 2003 Mar; 18(3):429-40.
Score: 0.187
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Cruz FM, Chan A, Rock KL. Pathways of MHC I cross-presentation of exogenous antigens. Semin Immunol. 2023 03; 66:101729.
Score: 0.187
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York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol. 2002 Dec; 3(12):1177-84.
Score: 0.184
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Goldberg AL, Cascio P, Saric T, Rock KL. The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. Mol Immunol. 2002 Oct; 39(3-4):147-64.
Score: 0.182
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Rock KL, York IA, Saric T, Goldberg AL. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol. 2002; 80:1-70.
Score: 0.173
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Mo XY, Cascio P, Lemerise K, Goldberg AL, Rock K. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. J Immunol. 1999 Dec 01; 163(11):5851-9.
Score: 0.150
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York IA, Goldberg AL, Mo XY, Rock KL. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol Rev. 1999 Dec; 172:49-66.
Score: 0.150
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Sigal LJ, Crotty S, Andino R, Rock KL. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature. 1999 Mar 04; 398(6722):77-80.
Score: 0.142
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Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol. 1999; 17:739-79.
Score: 0.140
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Craiu A, Akopian T, Goldberg A, Rock KL. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10850-5.
Score: 0.129
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Craiu A, Gaczynska M, Akopian T, Gramm CF, Fenteany G, Goldberg AL, Rock KL. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem. 1997 May 16; 272(20):13437-45.
Score: 0.125
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Shen Z, Reznikoff G, Dranoff G, Rock KL. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J Immunol. 1997 Mar 15; 158(6):2723-30.
Score: 0.124
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Cruz FM, Colbert JD, Merino E, Kriegsman BA, Rock KL. The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules. Annu Rev Immunol. 2017 04 26; 35:149-176.
Score: 0.122
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Michalek MT, Grant EP, Rock KL. Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation. J Immunol. 1996 Jul 15; 157(2):617-24.
Score: 0.118
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Kincaid EZ, Murata S, Tanaka K, Rock KL. Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells. Nat Immunol. 2016 08; 17(8):938-45.
Score: 0.118
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Rock KL. A new foreign policy: MHC class I molecules monitor the outside world. Immunol Today. 1996 Mar; 17(3):131-7.
Score: 0.115
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York IA, Rock KL. Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol. 1996; 14:369-96.
Score: 0.114
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Grant EP, Michalek MT, Goldberg AL, Rock KL. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation. J Immunol. 1995 Oct 15; 155(8):3750-8.
Score: 0.112
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Kovacsovics-Bankowski M, Rock KL. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science. 1995 Jan 13; 267(5195):243-6.
Score: 0.107
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Kovacsovics-Bankowski M, Rock KL. Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines. Eur J Immunol. 1994 Oct; 24(10):2421-8.
Score: 0.105
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Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 09; 78(5):761-71.
Score: 0.104
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Kovacsovics-Bankowski M, Clark K, Benacerraf B, Rock KL. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):4942-6.
Score: 0.095
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Rock KL, Rothstein L, Gamble S, Fleischacker C. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J Immunol. 1993 Jan 15; 150(2):438-46.
Score: 0.093
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Rock KL, Rothstein L, Benacerraf B. Analysis of the association of peptides of optimal length to class I molecules on the surface of cells. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):8918-22.
Score: 0.091
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Rock KL, Rothstein L, Fleischacker C, Gamble S. Inhibition of class I and class II MHC-restricted antigen presentation by cytotoxic T lymphocytes specific for an exogenous antigen. J Immunol. 1992 May 15; 148(10):3028-33.
Score: 0.089
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Rock KL, Rothstein L, Gamble S, Gramm C, Benacerraf B. Chemical cross-linking of class I molecules on cells creates receptive peptide binding sites. J Immunol. 1992 Mar 01; 148(5):1451-7.
Score: 0.087
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Grant EP, Rock KL. MHC class I-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo. J Immunol. 1992 Jan 01; 148(1):13-8.
Score: 0.086
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Rock KL, Gamble S, Rothstein L, Gramm C, Benacerraf B. Dissociation of beta 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell. 1991 May 17; 65(4):611-20.
Score: 0.083
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Rock KL, Gramm C, Benacerraf B. Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4200-4.
Score: 0.083
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Michalek MT, Benacerraf B, Rock KL. Weak base amines can inhibit class I MHC-restricted antigen presentation. J Immunol. 1991 Jan 15; 146(2):449-56.
Score: 0.081
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Rock KL, Gamble S, Rothstein L, Benacerraf B. Reassociation with beta 2-microglobulin is necessary for Db class I major histocompatibility complex binding of an exogenous influenza peptide. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):301-4.
Score: 0.081
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Rock KL, Rothstein LE, Gamble SR, Benacerraf B. Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7517-21.
Score: 0.079
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Rock KL, Gamble S, Rothstein L. Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science. 1990 Aug 24; 249(4971):918-21.
Score: 0.079
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Rock KL, Rothstein L, Gamble S. Generation of class I MHC-restricted T-T hybridomas. J Immunol. 1990 Aug 01; 145(3):804-11.
Score: 0.078
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Rock KL, Farf?n-Arribas DJ, Shen L. Proteases in MHC class I presentation and cross-presentation. J Immunol. 2010 Jan 01; 184(1):9-15.
Score: 0.075
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Towne CF, York IA, Watkin LB, Lazo JS, Rock KL. Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses. J Immunol. 2007 Jun 01; 178(11):6923-30.
Score: 0.063
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Rock KL, Shen L. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol Rev. 2005 Oct; 207:166-83.
Score: 0.056
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Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol. 2002 Dec; 3(12):1169-76.
Score: 0.046
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Raychaudhuri S, Rock KL. Fully mobilizing host defense: building better vaccines. Nat Biotechnol. 1998 Nov; 16(11):1025-31.
Score: 0.035
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Henderson SC, Berezovskaya A, English A, Palliser D, Rock KL, Bamezai A. CD4+ T cells mature in the absence of MHC class I and class II expression in Ly-6A.2 transgenic mice. J Immunol. 1998 Jul 01; 161(1):175-82.
Score: 0.034
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Mazzaccaro RJ, Gedde M, Jensen ER, van Santen HM, Ploegh HL, Rock KL, Bloom BR. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11786-91.
Score: 0.030
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Rock KL, Fleischacker C, Gamble S. Peptide-priming of cytolytic T cell immunity in vivo using beta 2-microglobulin as an adjuvant. J Immunol. 1993 Feb 15; 150(4):1244-52.
Score: 0.023
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Georgiadou D, Hearn A, Evnouchidou I, Chroni A, Leondiadis L, York IA, Rock KL, Stratikos E. Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. J Immunol. 2010 Aug 01; 185(3):1584-92.
Score: 0.019
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Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct; 1(7):533-41.
Score: 0.007
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Gaczynska M, Rock KL, Goldberg AL. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 1993 Sep 16; 365(6443):264-7.
Score: 0.006
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Gaczynska M, Rock KL, Goldberg AL. Role of proteasomes in antigen presentation. Enzyme Protein. 1993; 47(4-6):354-69.
Score: 0.006