Lila Gierasch to Models, Molecular
This is a "connection" page, showing publications Lila Gierasch has written about Models, Molecular.
Connection Strength
3.769
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Lai AL, Clerico EM, Blackburn ME, Patel NA, Robinson CV, Borbat PP, Freed JH, Gierasch LM. Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance. J Biol Chem. 2017 05 26; 292(21):8773-8785.
Score: 0.383
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Zhuravleva A, Gierasch LM. Substrate-binding domain conformational dynamics mediate Hsp70 allostery. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2865-73.
Score: 0.335
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Hingorani KS, Gierasch LM. How bacteria survive an acid trip. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5279-80.
Score: 0.289
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Bhasne K, Dörries L, Maqtedar A, Mager ST, Clerico EM, Gierasch LM. Model Peptides Enable Comparisons of Substrate Binding Modes of Hsp70 Molecular Chaperones. Biochemistry. 2026 Apr 21; 65(8):1214-1223.
Score: 0.178
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Maqtedar A, Rossi MA, Clerico EM, Williams RV, Gierasch LM. The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate-binding domain. J Biol Chem. 2026 Mar; 302(3):111176.
Score: 0.175
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Nordquist EB, Clerico EM, Chen J, Gierasch LM. Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future. J Phys Chem B. 2022 09 15; 126(36):6780-6791.
Score: 0.139
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Clerico EM, Pozhidaeva AK, Jansen RM, Özden C, Tilitsky JM, Gierasch LM. Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc Natl Acad Sci U S A. 2021 10 12; 118(41).
Score: 0.130
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Clerico EM, Meng W, Pozhidaeva A, Bhasne K, Petridis C, Gierasch LM. Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines. Biochem J. 2019 06 14; 476(11):1653-1677.
Score: 0.111
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Meng W, Clerico EM, McArthur N, Gierasch LM. Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):11970-11975.
Score: 0.106
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Thakur AK, Meng W, Gierasch LM. Local and non-local topological information in the denatured state ensemble of a ?-barrel protein. Protein Sci. 2018 12; 27(12):2062-2072.
Score: 0.106
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English CA, Sherman W, Meng W, Gierasch LM. The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains. J Biol Chem. 2017 09 08; 292(36):14765-14774.
Score: 0.097
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Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM. Ligand-promoted protein folding by biased kinetic partitioning. Nat Chem Biol. 2017 04; 13(4):369-371.
Score: 0.095
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Clerico EM, Tilitsky JM, Meng W, Gierasch LM. How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions. J Mol Biol. 2015 Apr 10; 427(7):1575-88.
Score: 0.082
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General IJ, Liu Y, Blackburn ME, Mao W, Gierasch LM, Bahar I. ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones. PLoS Comput Biol. 2014 May; 10(5):e1003624.
Score: 0.078
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Hingorani KS, Gierasch LM. Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge. Curr Opin Struct Biol. 2014 Feb; 24:81-90.
Score: 0.076
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Ferrolino MC, Zhuravleva A, Budyak IL, Krishnan B, Gierasch LM. Delicate balance between functionally required flexibility and aggregation risk in a ?-rich protein. Biochemistry. 2013 Dec 10; 52(49):8843-54.
Score: 0.076
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Budyak IL, Zhuravleva A, Gierasch LM. The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ?-Sheets. J Mol Biol. 2013 Sep 23; 425(18):3522-35.
Score: 0.073
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Zhuravleva A, Clerico EM, Gierasch LM. An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones. Cell. 2012 Dec 07; 151(6):1296-307.
Score: 0.071
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Krishnan B, Gierasch LM. Dynamic local unfolding in the serpin ?-1 antitrypsin provides a mechanism for loop insertion and polymerization. Nat Struct Mol Biol. 2011 Feb; 18(2):222-6.
Score: 0.062
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Stradley SJ, Rizo J, Bruch MD, Stroup AN, Gierasch LM. Cyclic pentapeptides as models for reverse turns: determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala beta-turns. Biopolymers. 1990 Jan; 29(1):263-87.
Score: 0.058
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Hebert DN, Gierasch LM. The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner. Mol Cell. 2009 Jun 26; 34(6):635-6.
Score: 0.056
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Smock RG, Gierasch LM. Sending signals dynamically. Science. 2009 Apr 10; 324(5924):198-203.
Score: 0.055
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Krishnan B, Gierasch LM. Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein. Chem Biol. 2008 Oct 20; 15(10):1104-15.
Score: 0.053
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Marcelino AM, Gierasch LM. Roles of beta-turns in protein folding: from peptide models to protein engineering. Biopolymers. 2008 May; 89(5):380-91.
Score: 0.051
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Clérico EM, Maki JL, Gierasch LM. Use of synthetic signal sequences to explore the protein export machinery. Biopolymers. 2008; 90(3):307-19.
Score: 0.050
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Ignatova Z, Krishnan B, Bombardier JP, Marcelino AM, Hong J, Gierasch LM. From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein. Biopolymers. 2007; 88(2):157-63.
Score: 0.047
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Marcelino AM, Smock RG, Gierasch LM. Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family. Proteins. 2006 May 01; 63(2):373-84.
Score: 0.045
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Swain JF, Schulz EG, Gierasch LM. Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states. J Biol Chem. 2006 Jan 20; 281(3):1605-11.
Score: 0.043
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Gunasekaran K, Hagler AT, Gierasch LM. Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions. Proteins. 2004 Feb 01; 54(2):179-94.
Score: 0.038
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Rotondi KS, Rotondi LF, Gierasch LM. Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein. Biophys Chem. 2003; 100(1-3):421-36.
Score: 0.035
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Rotondi KS, Gierasch LM. Local sequence information in cellular retinoic acid-binding protein I: specific residue roles in beta-turns. Biopolymers. 2003; 71(6):638-51.
Score: 0.035
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Chou YT, Swain JF, Gierasch LM. Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR. J Biol Chem. 2002 Dec 27; 277(52):50985-90.
Score: 0.035
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Cleverley RM, Gierasch LM. Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain. J Biol Chem. 2002 Nov 29; 277(48):46763-8.
Score: 0.035
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Gierasch LM. Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine. Mol Cell. 2002 Jan; 9(1):3-5.
Score: 0.033
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Cleverley RM, Zheng N, Gierasch LM. The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle. J Biol Chem. 2001 Jun 01; 276(22):19327-31.
Score: 0.031
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Gunasekaran K, Eyles SJ, Hagler AT, Gierasch LM. Keeping it in the family: folding studies of related proteins. Curr Opin Struct Biol. 2001 Feb; 11(1):83-93.
Score: 0.031
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Swain JF, Sivendran R, Gierasch LM. Defining the structure of the substrate-free state of the DnaK molecular chaperone. Biochem Soc Symp. 2001; (68):69-82.
Score: 0.031
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Pobre KFR, Powers DL, Ghosh K, Gierasch LM, Powers ET. Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment. Protein Sci. 2019 07; 28(7):1324-1339.
Score: 0.028
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Montgomery DL, Morimoto RI, Gierasch LM. Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol. 1999 Feb 26; 286(3):915-32.
Score: 0.027
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Feng HP, Gierasch LM. Molecular chaperones: clamps for the Clps? Curr Biol. 1998 Jun 18; 8(13):R464-7.
Score: 0.026
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Sukumar M, Rizo J, Wall M, Dreyfus LA, Kupersztoch YM, Gierasch LM. The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism. Protein Sci. 1995 Sep; 4(9):1718-29.
Score: 0.021
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Gershenson A, Gierasch LM, Pastore A, Radford SE. Energy landscapes of functional proteins are inherently risky. Nat Chem Biol. 2014 Nov; 10(11):884-91.
Score: 0.020
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Landry SJ, Gierasch LM. Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding. Annu Rev Biophys Biomol Struct. 1994; 23:645-69.
Score: 0.019
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Stradley SJ, Rizo J, Gierasch LM. Conformation of a heptapeptide substrate bound to protein farnesyltransferase. Biochemistry. 1993 Nov 30; 32(47):12586-90.
Score: 0.019
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Bienstock RJ, Rizo J, Koerber SC, Rivier JE, Hagler AT, Gierasch LM. Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics. J Med Chem. 1993 Oct 29; 36(22):3265-73.
Score: 0.019
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Stroup AN, Rockwell AL, Gierasch LM. Solution conformations of two flexible cyclic pentapeptides: cyclo(Gly-Pro-D-Phe-Gly-Ala) and cyclo(Gly-Pro-D-Phe-Gly-Val). Biopolymers. 1992 Dec; 32(12):1713-25.
Score: 0.018
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Rizo J, Gierasch LM. Constrained peptides: models of bioactive peptides and protein substructures. Annu Rev Biochem. 1992; 61:387-418.
Score: 0.017
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Bansal A, Gierasch LM. The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation. Cell. 1991 Dec 20; 67(6):1195-201.
Score: 0.017
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Ghosh RP, Nikitina T, Horowitz-Scherer RA, Gierasch LM, Uversky VN, Hite K, Hansen JC, Woodcock CL. Unique physical properties and interactions of the domains of methylated DNA binding protein 2. Biochemistry. 2010 May 25; 49(20):4395-410.
Score: 0.015
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Ghosh RP, Horowitz-Scherer RA, Nikitina T, Gierasch LM, Woodcock CL. Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions. J Biol Chem. 2008 Jul 18; 283(29):20523-34.
Score: 0.013
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Baniak EL, Rivier JE, Struthers RS, Hagler AT, Gierasch LM. Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone. Biochemistry. 1987 May 05; 26(9):2642-56.
Score: 0.012
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Mainprize IL, Beniac DR, Falkovskaia E, Cleverley RM, Gierasch LM, Ottensmeyer FP, Andrews DW. The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy. Mol Biol Cell. 2006 Dec; 17(12):5063-74.
Score: 0.011
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Cavanaugh LF, Palmer AG, Gierasch LM, Hunt JF. Disorder breathes life into a DEAD motor. Nat Struct Mol Biol. 2006 Jul; 13(7):566-9.
Score: 0.011
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Gierasch LM, Deber CM, Madison V, Niu CH, Blout ER. Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins. Biochemistry. 1981 Aug 04; 20(16):4730-8.
Score: 0.008
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Krishnan VV, Sukumar M, Gierasch LM, Cosman M. Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding. Biochemistry. 2000 Aug 08; 39(31):9119-29.
Score: 0.008
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Pellecchia M, Montgomery DL, Stevens SY, Vander Kooi CW, Feng HP, Gierasch LM, Zuiderweg ER. Structural insights into substrate binding by the molecular chaperone DnaK. Nat Struct Biol. 2000 Apr; 7(4):298-303.
Score: 0.007
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Eyles SJ, Dresch T, Gierasch LM, Kaltashov IA. Unfolding dynamics of a beta-sheet protein studied by mass spectrometry. J Mass Spectrom. 1999 Dec; 34(12):1289-95.
Score: 0.007
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Kibbey RG, Rizo J, Gierasch LM, Anderson RG. The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation. J Cell Biol. 1998 Jul 13; 142(1):59-67.
Score: 0.007
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Zhi W, Landry SJ, Gierasch LM, Srere PA. Renaturation of citrate synthase: influence of denaturant and folding assistants. Protein Sci. 1992 Apr; 1(4):522-9.
Score: 0.004
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Zhang J, Liu ZP, Jones TA, Gierasch LM, Sambrook JF. Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability. Proteins. 1992 Apr; 13(2):87-99.
Score: 0.004
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Struthers RS, Tanaka G, Koerber SC, Solmajer T, Baniak EL, Gierasch LM, Vale W, Rivier J, Hagler AT. Design of biologically active, conformationally constrained GnRH antagonists. Proteins. 1990; 8(4):295-304.
Score: 0.004
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Rose GD, Gierasch LM, Smith JA. Turns in peptides and proteins. Adv Protein Chem. 1985; 37:1-109.
Score: 0.003