Jeanne Hardy to Humans
This is a "connection" page, showing publications Jeanne Hardy has written about Humans.
Connection Strength
0.580
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Makhaik S, Rut W, Choudhary S, Upadhyay T, Hao C, Westberg M, Bobst C, Yoo E, Fejzo J, Lin MZ, Bogyo M, Thompson P, Drag M, Hardy JA. A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity. Protein Sci. 2025 Mar; 34(3):e70069.
Score: 0.035
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Cruz KG, Alexander K, Makhaik S, Hardy JA. FRET Probes for Detection of Both Active and Inactive Zika Virus Protease. Biochemistry. 2024 12 17; 63(24):3300-3309.
Score: 0.035
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Cruz KG, Hill Eron M, Makhaik S, Savinov S, Hardy JA. A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease. ACS Infect Dis. 2024 02 09; 10(2):412-425.
Score: 0.033
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Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. 2021 09 21; 60(37):2824-2835.
Score: 0.028
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Anson F, Kanjilal P, Thayumanavan S, Hardy JA. Tracking exogenous intracellular casp-3 using split GFP. Protein Sci. 2021 02; 30(2):366-380.
Score: 0.026
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MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. J Biol Chem. 2019 01 04; 294(1):71-88.
Score: 0.023
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Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. ACS Chem Biol. 2018 09 21; 13(9):2398-2405.
Score: 0.022
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Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA. Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8. ACS Chem Biol. 2018 05 18; 13(5):1279-1290.
Score: 0.022
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Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD?:?core domain interactions require a properly formed active site. Biochem J. 2018 03 29; 475(6):1177-1196.
Score: 0.022
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Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core. Cell Death Differ. 2018 06; 25(6):1025-1039.
Score: 0.022
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Serrano BP, Szydlo HS, Alfandari D, Hardy JA. Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. J Biol Chem. 2017 12 29; 292(52):21352-21365.
Score: 0.021
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Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E7977-E7986.
Score: 0.021
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Dagbay KB, Hill ME, Barrett E, Hardy JA. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. 2017 08 29; 56(34):4568-4577.
Score: 0.021
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Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. J Biol Chem. 2017 03 24; 292(12):4885-4897.
Score: 0.020
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Eron SJ, Raghupathi K, Hardy JA. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure. 2017 01 03; 25(1):27-39.
Score: 0.020
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Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 06 17; 11(6):1603-12.
Score: 0.019
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Dagbay K, Eron SJ, Serrano BP, Vel?zquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA. A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods Enzymol. 2014; 544:215-49.
Score: 0.016
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Wu P, Nicholls SB, Hardy JA. A tunable, modular approach to fluorescent protease-activated reporters. Biophys J. 2013 Apr 02; 104(7):1605-14.
Score: 0.015
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Vel?zquez-Delgado EM, Hardy JA. Zinc-mediated allosteric inhibition of caspase-6. J Biol Chem. 2012 Oct 19; 287(43):36000-11.
Score: 0.015
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Huber KL, Hardy JA. Mechanism of zinc-mediated inhibition of caspase-9. Protein Sci. 2012 Jul; 21(7):1056-65.
Score: 0.015
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Vel?zquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure. 2012 Apr 04; 20(4):742-51.
Score: 0.014
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Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 2012; 98(5):451-65.
Score: 0.014
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Vaidya S, Vel?zquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol. 2011 Feb 11; 406(1):75-91.
Score: 0.013
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Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem. 2009 Sep 18; 284(38):26063-9.
Score: 0.012
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Huber KL, Olson KD, Hardy JA. Robust production of a peptide library using methodological synchronization. Protein Expr Purif. 2009 Oct; 67(2):139-47.
Score: 0.012
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Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Curr Opin Struct Biol. 2004 Dec; 14(6):706-15.
Score: 0.009
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Dutta R, Makhaik S, Zhao P, Cruz KG, Park KW, Liu H, Andrew TL, Hardy JA, Thayumanavan S. Colorimetric Cotton Swab for Viral Protease Detection. Anal Chem. 2022 09 20; 94(37):12699-12705.
Score: 0.007
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Raman V, Van Dessel N, Hall CL, Wetherby VE, Whitney SA, Kolewe EL, Bloom SMK, Sharma A, Hardy JA, Bollen M, Van Eynde A, Forbes NS. Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases. Nat Commun. 2021 10 21; 12(1):6116.
Score: 0.007
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Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. ACS Chem Biol. 2021 11 19; 16(11):2280-2296.
Score: 0.007
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Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodr?guez R. A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. J Biol Chem. 2020 02 21; 295(8):2212-2226.
Score: 0.006
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Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. 2019 12 31; 58(52):5320-5328.
Score: 0.006
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Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Sci Rep. 2018 03 13; 8(1):4428.
Score: 0.005
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Raghupathi K, Eron SJ, Anson F, Hardy JA, Thayumanavan S. Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery. Mol Pharm. 2017 12 04; 14(12):4515-4524.
Score: 0.005
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Kim CS, Mout R, Zhao Y, Yeh YC, Tang R, Jeong Y, Duncan B, Hardy JA, Rotello VM. Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules. Bioconjug Chem. 2015 May 20; 26(5):950-4.
Score: 0.004
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Tang R, Kim CS, Solfiell DJ, Rana S, Mout R, Vel?zquez-Delgado EM, Chompoosor A, Jeong Y, Yan B, Zhu ZJ, Kim C, Hardy JA, Rotello VM. Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. ACS Nano. 2013 Aug 27; 7(8):6667-6673.
Score: 0.004
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Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS. Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics. Biol Chem. 2012 Sep; 393(9):933-41.
Score: 0.004