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Arthur Mercurio to Humans

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This is a "connection" page, showing publications Arthur Mercurio has written about Humans.
Arthur Mercurio
Connection Strength
1.274
Humans
  1. Karner ER, Wang M, Goel HL, Mercurio AM. GATA3 promotes ferroptosis resistance by repressing integrin ?1 signaling. Proc Natl Acad Sci U S A. 2025 Aug 26; 122(34):e2427304122.
    View in: PubMed
    Score: 0.037
  2. Wang M, Prachyathipsakul T, Wisniewski CA, Xiong C, Goel S, Goel HL, Karner ER, Mukhopadhyay D, Gupta P, Majee A, Thayumanavan S, Mercurio AM. Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates. Cell Chem Biol. 2024 Dec 19; 31(12):2039-2051.e6.
    View in: PubMed
    Score: 0.035
  3. Kumar A, Goel HL, Silva CA, Wang T, Geng Y, Wang M, Goel S, Hu K, Li R, Zhu LJ, Clark JL, Ferreira LM, Brehm MA, FitzGerald TJ, Mercurio AM. Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling. J Clin Invest. 2024 10 01; 134(22).
    View in: PubMed
    Score: 0.035
  4. Goel HL, Karner ER, Kumar A, Mukhopadhyay D, Goel S, Mercurio AM. YAP/TAZ-mediated regulation of laminin 332 is enabled by ?4 integrin repression of ZEB1 to promote ferroptosis resistance. J Biol Chem. 2024 04; 300(4):107202.
    View in: PubMed
    Score: 0.033
  5. Wang M, Silva CA, Xiong C, Chhoy P, Goel HL, Kumar A, Zhu LJ, Li R, St Louis PA, Ferreira LM, Pakula H, Xu Z, Loda M, Jiang Z, Brehm MA, Mercurio AM. Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Sci Transl Med. 2023 05 03; 15(694):eade5855.
    View in: PubMed
    Score: 0.031
  6. Xu Z, Goel HL, Burkart C, Burman L, Chong YE, Barber AG, Geng Y, Zhai L, Wang M, Kumar A, Menefee A, Polizzi C, Eide L, Rauch K, Rahman J, Hamel K, Fogassy Z, Klopp-Savino S, Paz S, Zhang M, Cubitt A, Nangle LA, Mercurio AM. Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Sci Transl Med. 2023 05 03; 15(694):eadf1128.
    View in: PubMed
    Score: 0.031
  7. Chhoy P, Brown CW, Amante JJ, Mercurio AM. Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models. STAR Protoc. 2021 03 19; 2(1):100303.
    View in: PubMed
    Score: 0.027
  8. Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, Baer CE, Dixon SJ, Mercurio AM. Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019 12 02; 51(5):575-586.e4.
    View in: PubMed
    Score: 0.025
  9. Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 07 31; 132(15).
    View in: PubMed
    Score: 0.024
  10. Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM. The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14174-14180.
    View in: PubMed
    Score: 0.024
  11. Mercurio AM. VEGF/Neuropilin Signaling in Cancer Stem Cells. Int J Mol Sci. 2019 Jan 23; 20(3).
    View in: PubMed
    Score: 0.023
  12. Elaimy AL, Mercurio AM. Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology. Sci Signal. 2018 10 16; 11(552).
    View in: PubMed
    Score: 0.023
  13. Brown CW, Amante JJ, Mercurio AM. Cell clustering mediated by the adhesion protein PVRL4 is necessary for a6?4 integrin-promoted ferroptosis resistance in matrix-detached cells. J Biol Chem. 2018 08 17; 293(33):12741-12748.
    View in: PubMed
    Score: 0.022
  14. Samanta S, Guru S, Elaimy AL, Amante JJ, Ou J, Yu J, Zhu LJ, Mercurio AM. IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer. Cell Rep. 2018 05 29; 23(9):2559-2567.
    View in: PubMed
    Score: 0.022
  15. Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM. VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin. Sci Signal. 2018 05 01; 11(528).
    View in: PubMed
    Score: 0.022
  16. Brown CW, Amante JJ, Goel HL, Mercurio AM. The a6?4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017 12 04; 216(12):4287-4297.
    View in: PubMed
    Score: 0.021
  17. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-2208.
    View in: PubMed
    Score: 0.019
  18. Mak P, Li J, Samanta S, Mercurio AM. ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1. Oncotarget. 2015 Nov 24; 6(37):40247-54.
    View in: PubMed
    Score: 0.019
  19. Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM. IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. Oncogene. 2016 Mar 03; 35(9):1111-21.
    View in: PubMed
    Score: 0.018
  20. Mak P, Li J, Samanta S, Chang C, Jerry DJ, Davis RJ, Leav I, Mercurio AM. Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression. Cell Rep. 2015 Mar 31; 10(12):1982-91.
    View in: PubMed
    Score: 0.018
  21. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6.
    View in: PubMed
    Score: 0.018
  22. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 08; 7(3):747-61.
    View in: PubMed
    Score: 0.017
  23. Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013 Dec; 13(12):871-82.
    View in: PubMed
    Score: 0.016
  24. Chang C, Yang X, Pursell B, Mercurio AM. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4. Mol Cell Biol. 2013 Oct; 33(19):3795-804.
    View in: PubMed
    Score: 0.016
  25. Samanta S, Pursell B, Mercurio AM. IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression. J Biol Chem. 2013 May 03; 288(18):12569-73.
    View in: PubMed
    Score: 0.016
  26. Mak P, Chang C, Pursell B, Mercurio AM. Estrogen receptor ? sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4708-13.
    View in: PubMed
    Score: 0.016
  27. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508.
    View in: PubMed
    Score: 0.015
  28. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr. 2012 Nov-Dec; 6(6):554-60.
    View in: PubMed
    Score: 0.015
  29. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21.
    View in: PubMed
    Score: 0.015
  30. Gerson KD, Shearstone JR, Maddula VSRK, Seligmann BE, Mercurio AM. Integrin ?4 regulates SPARC protein to promote invasion. J Biol Chem. 2012 Mar 23; 287(13):9835-9844.
    View in: PubMed
    Score: 0.014
  31. Samanta S, Sharma VM, Khan A, Mercurio AM. Regulation of IMP3 by EGFR signaling and repression by ER?: implications for triple-negative breast cancer. Oncogene. 2012 Nov 01; 31(44):4689-97.
    View in: PubMed
    Score: 0.014
  32. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6?1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Jan 15; 125(Pt 2):497-506.
    View in: PubMed
    Score: 0.014
  33. Moriarty CH, Pursell B, Mercurio AM. miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem. 2010 Jul 02; 285(27):20541-6.
    View in: PubMed
    Score: 0.013
  34. Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM, Mercurio AM. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 2010 Apr 13; 17(4):319-32.
    View in: PubMed
    Score: 0.013
  35. Bae D, Lu S, Taglienti CA, Mercurio AM. Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem. 2008 Oct 17; 283(42):28074-80.
    View in: PubMed
    Score: 0.011
  36. Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8.
    View in: PubMed
    Score: 0.011
  37. Merdek KD, Yang X, Taglienti CA, Shaw LM, Mercurio AM. Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem. 2007 Oct 12; 282(41):30322-30.
    View in: PubMed
    Score: 0.011
  38. Folgiero V, Bachelder RE, Bon G, Sacchi A, Falcioni R, Mercurio AM. The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. Cancer Res. 2007 Feb 15; 67(4):1645-52.
    View in: PubMed
    Score: 0.010
  39. Bates RC, Pursell BM, Mercurio AM. Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs. 2007; 185(1-3):29-39.
    View in: PubMed
    Score: 0.010
  40. Yoon SO, Shin S, Mercurio AM. Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res. 2006 Jun 15; 66(12):6288-95.
    View in: PubMed
    Score: 0.010
  41. Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P, Mercurio AM. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene. 2006 Nov 02; 25(52):6959-67.
    View in: PubMed
    Score: 0.010
  42. Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res. 2005 Dec 01; 65(23):10938-45.
    View in: PubMed
    Score: 0.009
  43. Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS, Mercurio AM. The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res. 2005 Dec 01; 65(23):10970-6.
    View in: PubMed
    Score: 0.009
  44. Mercurio AM, Lipscomb EA, Bachelder RE. Non-angiogenic functions of VEGF in breast cancer. J Mammary Gland Biol Neoplasia. 2005 Oct; 10(4):283-90.
    View in: PubMed
    Score: 0.009
  45. Lipscomb EA, Mercurio AM. Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 2005 Sep; 24(3):413-23.
    View in: PubMed
    Score: 0.009
  46. Bates RC, Mercurio AM. The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther. 2005 Apr; 4(4):365-70.
    View in: PubMed
    Score: 0.009
  47. Yoon SO, Shin S, Mercurio AM. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Cancer Res. 2005 Apr 01; 65(7):2761-9.
    View in: PubMed
    Score: 0.009
  48. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47.
    View in: PubMed
    Score: 0.009
  49. Whalen JM, Earley J, Silva C, Mercurio AM, Cantor SB. Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nat Cancer. 2025 Feb; 6(2):278-291.
    View in: PubMed
    Score: 0.009
  50. Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol. 2005 Jan 03; 168(1):29-33.
    View in: PubMed
    Score: 0.009
  51. Simpson KJ, Dugan AS, Mercurio AM. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res. 2004 Dec 01; 64(23):8694-701.
    View in: PubMed
    Score: 0.009
  52. Bates RC, DeLeo MJ, Mercurio AM. The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp Cell Res. 2004 Oct 01; 299(2):315-24.
    View in: PubMed
    Score: 0.009
  53. Chung J, Yoon S, Datta K, Bachelder RE, Mercurio AM. Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. Cancer Res. 2004 Jul 15; 64(14):4711-6.
    View in: PubMed
    Score: 0.009
  54. Chung J, Yoon SO, Lipscomb EA, Mercurio AM. The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J Biol Chem. 2004 Jul 30; 279(31):32287-93.
    View in: PubMed
    Score: 0.008
  55. Rabinovitz I, Tsomo L, Mercurio AM. Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol. 2004 May; 24(10):4351-60.
    View in: PubMed
    Score: 0.008
  56. Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells. 2004 Apr 30; 17(2):203-9.
    View in: PubMed
    Score: 0.008
  57. Mercurio AM, Bachelder RE, Bates RC, Chung J. Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Semin Cancer Biol. 2004 Apr; 14(2):115-22.
    View in: PubMed
    Score: 0.008
  58. Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 11; 623(7987):625-632.
    View in: PubMed
    Score: 0.008
  59. Bates RC, Goldsmith JD, Bachelder RE, Brown C, Shibuya M, Oettgen P, Mercurio AM. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol. 2003 Sep 30; 13(19):1721-7.
    View in: PubMed
    Score: 0.008
  60. Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ, Mercurio AM. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res. 2003 Sep 01; 63(17):5230-3.
    View in: PubMed
    Score: 0.008
  61. Mercurio AM. Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way. Cancer Cell. 2003 Mar; 3(3):201-2.
    View in: PubMed
    Score: 0.008
  62. Bates RC, Mercurio AM. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell. 2003 May; 14(5):1790-800.
    View in: PubMed
    Score: 0.008
  63. Lipscomb EA, Dugan AS, Rabinovitz I, Mercurio AM. Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis. 2003; 20(6):569-76.
    View in: PubMed
    Score: 0.008
  64. Bachelder RE, Wendt MA, Mercurio AM. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res. 2002 Dec 15; 62(24):7203-6.
    View in: PubMed
    Score: 0.008
  65. Chung J, Bachelder RE, Lipscomb EA, Shaw LM, Mercurio AM. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol. 2002 Jul 08; 158(1):165-74.
    View in: PubMed
    Score: 0.007
  66. Rabinovitz I, Gipson IK, Mercurio AM. Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion. Mol Biol Cell. 2001 Dec; 12(12):4030-43.
    View in: PubMed
    Score: 0.007
  67. O'Connor KL, Mercurio AM. Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem. 2001 Dec 21; 276(51):47895-900.
    View in: PubMed
    Score: 0.007
  68. Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, Mercurio AM. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 2001 Aug 01; 61(15):5736-40.
    View in: PubMed
    Score: 0.007
  69. Tani TT, Mercurio AM. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J Biol Chem. 2001 Sep 28; 276(39):36535-42.
    View in: PubMed
    Score: 0.007
  70. Mercurio AM, Bachelder RE, Chung J, O'Connor KL, Rabinovitz I, Shaw LM, Tani T. Integrin laminin receptors and breast carcinoma progression. J Mammary Gland Biol Neoplasia. 2001 Jul; 6(3):299-309.
    View in: PubMed
    Score: 0.007
  71. Mercurio AM, Rabinovitz I. Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin. Semin Cancer Biol. 2001 Apr; 11(2):129-41.
    View in: PubMed
    Score: 0.007
  72. Mercurio AM, Bachelder RE, Rabinovitz I, O'Connor KL, Tani T, Shaw LM. The metastatic odyssey: the integrin connection. Surg Oncol Clin N Am. 2001 Apr; 10(2):313-28, viii-ix.
    View in: PubMed
    Score: 0.007
  73. Geng Y, Amante JJ, Goel HL, Zhang X, Walker MR, Luther DC, Mercurio AM, Rotello VM. Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering. ACS Nano. 2020 11 24; 14(11):15276-15285.
    View in: PubMed
    Score: 0.007
  74. Barney LE, Hall CL, Schwartz AD, Parks AN, Sparages C, Galarza S, Platt MO, Mercurio AM, Peyton SR. Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. Sci Adv. 2020 03; 6(11):eaaz4157.
    View in: PubMed
    Score: 0.006
  75. Lotz MM, Rabinovitz I, Mercurio AM. Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol. 2000 Mar; 156(3):985-96.
    View in: PubMed
    Score: 0.006
  76. O'Connor KL, Nguyen BK, Mercurio AM. RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J Cell Biol. 2000 Jan 24; 148(2):253-8.
    View in: PubMed
    Score: 0.006
  77. Bachelder RE, Ribick MJ, Marchetti A, Falcioni R, Soddu S, Davis KR, Mercurio AM. p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol. 1999 Nov 29; 147(5):1063-72.
    View in: PubMed
    Score: 0.006
  78. Rabinovitz I, Toker A, Mercurio AM. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol. 1999 Sep 06; 146(5):1147-60.
    View in: PubMed
    Score: 0.006
  79. Bachelder RE, Marchetti A, Falcioni R, Soddu S, Mercurio AM. Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. J Biol Chem. 1999 Jul 16; 274(29):20733-7.
    View in: PubMed
    Score: 0.006
  80. Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 02 01; 33(3-4):166-179.
    View in: PubMed
    Score: 0.006
  81. O'Connor KL, Shaw LM, Mercurio AM. Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J Cell Biol. 1998 Dec 14; 143(6):1749-60.
    View in: PubMed
    Score: 0.006
  82. Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM. Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays. Nanomedicine. 2018 08; 14(6):1931-1939.
    View in: PubMed
    Score: 0.006
  83. Rabinovitz I, Mercurio AM. The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol. 1997 Dec 29; 139(7):1873-84.
    View in: PubMed
    Score: 0.005
  84. Wewer UM, Shaw LM, Albrechtsen R, Mercurio AM. The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol. 1997 Nov; 151(5):1191-8.
    View in: PubMed
    Score: 0.005
  85. Wei J, Shaw LM, Mercurio AM. Integrin signaling in leukocytes: lessons from the alpha6beta1 integrin. J Leukoc Biol. 1997 Apr; 61(4):397-407.
    View in: PubMed
    Score: 0.005
  86. Lotz MM, Nusrat A, Madara JL, Ezzell R, Wewer UM, Mercurio AM. Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium. Am J Pathol. 1997 Feb; 150(2):747-60.
    View in: PubMed
    Score: 0.005
  87. Chao C, Lotz MM, Clarke AC, Mercurio AM. A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 1996 Oct 15; 56(20):4811-9.
    View in: PubMed
    Score: 0.005
  88. Yoshii T, Geng Y, Peyton S, Mercurio AM, Rotello VM. Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine. Drug Discov Today. 2016 09; 21(9):1489-1494.
    View in: PubMed
    Score: 0.005
  89. Shaw LM, Chao C, Wewer UM, Mercurio AM. Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor. Cancer Res. 1996 Mar 01; 56(5):959-63.
    View in: PubMed
    Score: 0.005
  90. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180.
    View in: PubMed
    Score: 0.005
  91. Rabinovitz I, Mercurio AM. The integrin alpha 6 beta 4 and the biology of carcinoma. Biochem Cell Biol. 1996; 74(6):811-21.
    View in: PubMed
    Score: 0.005
  92. Shaw LM, Turner CE, Mercurio AM. The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. J Biol Chem. 1995 Oct 06; 270(40):23648-52.
    View in: PubMed
    Score: 0.005
  93. Clarke AS, Lotz MM, Chao C, Mercurio AM. Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain. J Biol Chem. 1995 Sep 29; 270(39):22673-6.
    View in: PubMed
    Score: 0.005
  94. Breen E, Steele G, Mercurio AM. Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. Ann Surg Oncol. 1995 Sep; 2(5):378-85.
    View in: PubMed
    Score: 0.005
  95. Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW. Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure. 2015 Apr 07; 23(4):677-87.
    View in: PubMed
    Score: 0.004
  96. Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. A cell-ECM screening method to predict breast cancer metastasis. Integr Biol (Camb). 2015 Feb; 7(2):198-212.
    View in: PubMed
    Score: 0.004
  97. Shaw LM, Mercurio AM. Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages. Agents Actions Suppl. 1995; 47:101-6.
    View in: PubMed
    Score: 0.004
  98. Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ?4. FASEB J. 2015 Jan; 29(1):131-40.
    View in: PubMed
    Score: 0.004
  99. Clarke AS, Lotz MM, Mercurio AM. A novel structural variant of the human beta 4 integrin cDNA. Cell Adhes Commun. 1994 Apr; 2(1):1-6.
    View in: PubMed
    Score: 0.004
  100. Gao Y, Yang M, Jiang Z, Woda BA, Mercurio AM, Qin J, Huang X, Zhang F. IMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma. Hum Pathol. 2014 Jun; 45(6):1184-91.
    View in: PubMed
    Score: 0.004
  101. Breen E, Clarke A, Steele G, Mercurio AM. Poorly differentiated colon carcinoma cell lines deficient in alpha-catenin expression express high levels of surface E-cadherin but lack Ca(2+)-dependent cell-cell adhesion. Cell Adhes Commun. 1993 Dec; 1(3):239-50.
    View in: PubMed
    Score: 0.004
  102. Shaw LM, Mercurio AM. Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit. J Cell Biol. 1993 Nov; 123(4):1017-25.
    View in: PubMed
    Score: 0.004
  103. Shaw LM, Lotz MM, Mercurio AM. Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line. J Biol Chem. 1993 May 25; 268(15):11401-8.
    View in: PubMed
    Score: 0.004
  104. Lotz MM, Andrews CW, Korzelius CA, Lee EC, Steele GD, Clarke A, Mercurio AM. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3466-70.
    View in: PubMed
    Score: 0.004
  105. Lee EC, Lotz MM, Steele GD, Mercurio AM. The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol. 1992 May; 117(3):671-8.
    View in: PubMed
    Score: 0.004
  106. Lee EC, Woo HJ, Korzelius CA, Steele GD, Mercurio AM. Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma. Arch Surg. 1991 Dec; 126(12):1498-502.
    View in: PubMed
    Score: 0.004
  107. Lu D, Yang X, Jiang NY, Woda BA, Liu Q, Dresser K, Mercurio AM, Rock KL, Jiang Z. IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. Am J Surg Pathol. 2011 Nov; 35(11):1638-45.
    View in: PubMed
    Score: 0.004
  108. Fr?hlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res. 2011 Nov; 9(11):1449-61.
    View in: PubMed
    Score: 0.003
  109. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Expression of enzymatically active sucrase-isomaltase is a ubiquitous property of colon adenocarcinomas. Gastroenterology. 1991 May; 100(5 Pt 1):1266-78.
    View in: PubMed
    Score: 0.003
  110. Mercurio AM. Laminin: multiple forms, multiple receptors. Curr Opin Cell Biol. 1990 Oct; 2(5):845-9.
    View in: PubMed
    Score: 0.003
  111. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Sucrase-isomaltase: a marker associated with the progression of adenomatous polyps to adenocarcinomas. Surgery. 1990 Aug; 108(2):269-75; discussion 275-6.
    View in: PubMed
    Score: 0.003
  112. Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One. 2010 Mar 08; 5(3):e9575.
    View in: PubMed
    Score: 0.003
  113. Lotz MM, Korzelius CA, Mercurio AM. Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins. Cell Regul. 1990 Feb; 1(3):249-57.
    View in: PubMed
    Score: 0.003
  114. Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, Altieri DC. IAP regulation of metastasis. Cancer Cell. 2010 Jan 19; 17(1):53-64.
    View in: PubMed
    Score: 0.003
  115. Daneker GW, Piazza AJ, Steele GD, Mercurio AM. Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines. Cancer Res. 1989 Feb 01; 49(3):681-6.
    View in: PubMed
    Score: 0.003
  116. Daneker GW, Piazza AJ, Steele GD, Mercurio AM. Interactions of human colorectal carcinoma cells with basement membranes. Analysis and correlation with differentiation. Arch Surg. 1989 Feb; 124(2):183-7.
    View in: PubMed
    Score: 0.003
  117. Kveiborg M, Fr?hlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, Wewer UM. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res. 2005 Jun 01; 65(11):4754-61.
    View in: PubMed
    Score: 0.002
  118. Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem. 2005 Apr 08; 280(14):13936-43.
    View in: PubMed
    Score: 0.002
  119. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004 Apr; 164(4):1131-9.
    View in: PubMed
    Score: 0.002
  120. Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, M?ller P, Mercurio AM, Albrechtsen R, Wewer UM. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci. 2003 Oct 01; 116(Pt 19):3893-904.
    View in: PubMed
    Score: 0.002
  121. Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM. ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem. 2003 Mar 14; 278(11):9576-84.
    View in: PubMed
    Score: 0.002
  122. Gambaletta D, Marchetti A, Benedetti L, Mercurio AM, Sacchi A, Falcioni R. Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J Biol Chem. 2000 Apr 07; 275(14):10604-10.
    View in: PubMed
    Score: 0.002
  123. Holtzman E, Mercurio AM. Membrane circulation in neurons and photoreceptors: some unresolved issues. Int Rev Cytol. 1980; 67:1-67.
    View in: PubMed
    Score: 0.002
  124. Homan SM, Mercurio AM, LaFlamme SE. Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail. J Cell Sci. 1998 Sep; 111 ( Pt 18):2717-28.
    View in: PubMed
    Score: 0.001
  125. Carloni V, Romanelli RG, Mercurio AM, Pinzani M, Laffi G, Cotrozzi G, Gentilini P. Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. Gastroenterology. 1998 Aug; 115(2):433-42.
    View in: PubMed
    Score: 0.001
  126. Lise M, Loda M, Fiorentino M, Mercurio AM, Summerhayes IC, Lavin PT, Jessup JM. Association between sucrase-isomaltase and p53 expression in colorectal cancer. Ann Surg Oncol. 1997 Mar; 4(2):176-83.
    View in: PubMed
    Score: 0.001
  127. Jessup JM, Lavin PT, Andrews CW, Loda M, Mercurio A, Minsky BD, Mies C, Cukor B, Bleday R, Steele G. Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma. Dis Colon Rectum. 1995 Dec; 38(12):1257-64.
    View in: PubMed
    Score: 0.001
  128. Byers SW, Sommers CL, Hoxter B, Mercurio AM, Tozeren A. Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength. J Cell Sci. 1995 May; 108 ( Pt 5):2053-64.
    View in: PubMed
    Score: 0.001
  129. T?zeren A, Kleinman HK, Grant DS, Morales D, Mercurio AM, Byers SW. E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers. Int J Cancer. 1995 Jan 27; 60(3):426-31.
    View in: PubMed
    Score: 0.001
  130. T?zeren A, Kleinman HK, Wu S, Mercurio AM, Byers SW. Integrin alpha 6 beta 4 mediates dynamic interactions with laminin. J Cell Sci. 1994 Nov; 107 ( Pt 11):3153-63.
    View in: PubMed
    Score: 0.001
  131. Rossen K, Dahlstr?m KK, Mercurio AM, Wewer UM. Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? Acta Derm Venereol. 1994 Mar; 74(2):101-5.
    View in: PubMed
    Score: 0.001
  132. Andrews CW, O'Hara CJ, Goldman H, Mercurio AM, Silverman ML, Steele GD. Sucrase-isomaltase expression in chronic ulcerative colitis and dysplasia. Hum Pathol. 1992 Jul; 23(7):774-9.
    View in: PubMed
    Score: 0.001
  133. Wewer UM, Mercurio AM, Chung SY, Albrechtsen R. Deoxyribonucleic-binding homeobox proteins are augmented in human cancer. Lab Invest. 1990 Oct; 63(4):447-54.
    View in: PubMed
    Score: 0.001
  134. Daneker GW, Mercurio AM, Guerra L, Wolf B, Salem RR, Bagli DJ, Steele GD. Laminin expression in colorectal carcinomas varying in degree of differentiation. Arch Surg. 1987 Dec; 122(12):1470-4.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.