Jae-Hyuck Shim to Humans
This is a "connection" page, showing publications Jae-Hyuck Shim has written about Humans.
Connection Strength
0.686
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Kim JM, Yang YS, Xie J, Kang CM, Cho YC, Park KH, Gong F, Sato T, Kim BJ, Gao G, Shim JH. USP24-dependent STAT2 stabilization mediates physiologic and pathologic bone formation. Cell Death Dis. 2026 May 30; 17(1).
Score: 0.036
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Chaugule S, Yang YS, Sato T, Mayer E, Shim JH. USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development. Cell Mol Life Sci. 2026 Jan 15; 83(1):72.
Score: 0.035
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Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. Mol Ther. 2025 Dec 03; 33(12):6379-6397.
Score: 0.034
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Chaugule S, Constantinou CK, John AA, Micha D, Eekhoff M, Gravallese E, Gao G, Shim JH. Comprehensive Review of Osteogenesis Imperfecta: Current Treatments and Future Innovations. Hum Gene Ther. 2025 03; 36(5-6):597-617.
Score: 0.033
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Lin C, Yang YS, Ma H, Chen Z, Chen D, John AA, Xie J, Gao G, Shim JH. Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss. Mol Ther. 2024 09 04; 32(9):3080-3100.
Score: 0.032
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Sato T, Chaugule S, Greenblatt MB, Gao G, Shim JH. Advances in Bone-Targeting Drug Delivery: Emerging Strategies Using Adeno-Associated Virus. Hum Gene Ther. 2024 05; 35(9-10):329-341.
Score: 0.031
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Lin C, Greenblatt MB, Gao G, Shim JH. Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal Diseases. Hum Gene Ther. 2024 05; 35(9-10):317-328.
Score: 0.031
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Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G, Shim JH. AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva. Biomolecules. 2023 09 08; 13(9).
Score: 0.030
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Stavre Z, Kim JM, Yang YS, N?ndel K, Chaugule S, Sato T, Park KH, Gao G, Gravallese EM, Shim JH. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2218019120.
Score: 0.029
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Yang YS, Kim JM, Xie J, Chaugule S, Lin C, Ma H, Hsiao E, Hong J, Chun H, Shore EM, Kaplan FS, Gao G, Shim JH. Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery. Nat Commun. 2022 10 19; 13(1):6175.
Score: 0.028
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Oh WT, Yang YS, Xie J, Ma H, Kim JM, Park KH, Oh DS, Park-Min KH, Greenblatt MB, Gao G, Shim JH. WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects. Mol Ther. 2023 02 01; 31(2):435-453.
Score: 0.028
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Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020 09 10; 9(9).
Score: 0.024
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Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289.
Score: 0.024
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Shim JH, Stavre Z, Gravallese EM. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcif Tissue Int. 2018 05; 102(5):533-546.
Score: 0.020
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Oh DS, Koch A, Eisig S, Kim SG, Kim YH, Kim DG, Shim JH. Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect. J Vis Exp. 2015 Sep 11; (103).
Score: 0.017
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Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301.
Score: 0.017
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Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep; 123(9):4010-22.
Score: 0.015
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Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest. 2012 Jan; 122(1):91-106.
Score: 0.013
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Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22; 28(14):2028-41.
Score: 0.011
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Zhytnik L, Ventura L, Sclocco A, Verhage M, Bakker AD, Shim JH, Beaino W, Pereira PM, Hoogeland ME, Heine VM, Maas H, Jaspers RT, Niehoff A, Zaucke F, de Waard V, Eekhoff EMW, Micha D. New lens on congenital mild bone fragility: a novel Col1a1 knockout mouse model for osteogenesis imperfecta type 1. J Bone Miner Res. 2026 Apr 26; 41(5):565-580.
Score: 0.009
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Micha D, Escalante Quir?s S, Eekhoff EMW, Heine VM, Shim JH, Zhytnik L. Modeling rare genetic skeletal disorders with bone organoids: a narrative review. Bone. 2026 04; 205:117799.
Score: 0.009
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Shin JH, Kim JY, Kim SH, Kang Y, Lee HJ, Kim MJ, Choi J, Jeong SK, Park SO, Cho YB, Kim KK, Shim JH, Chun E, Lee KY. USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis. Cell Death Dis. 2025 Dec 19; 16(1):894.
Score: 0.009
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Sarkar A, Sarkar S, Anwar A, Kim JW, Shim JH, John AA. The Growing Significance of microRNAs in Osteoporosis. Cells. 2025 12 01; 14(23).
Score: 0.009
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Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs. Nucleic Acids Res. 2025 Nov 26; 53(22).
Score: 0.009
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Shin JH, Kim JY, Kim MJ, Kang Y, Lee HJ, Choi B, Lee JS, Kwon D, Kim SH, Sung Y, Kim DH, Shim JH, Chun E, Lee KY. PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathways. Exp Mol Med. 2025 Nov; 57(11):2559-2573.
Score: 0.009
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Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005 Nov 15; 19(22):2668-81.
Score: 0.009
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Anwar A, Kaur T, Chaugule S, Yang YS, Mago A, Shim JH, John AA. Sensors in Bone: Technologies, Applications, and Future Directions. Sensors (Basel). 2024 Sep 24; 24(19).
Score: 0.008
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Anwar A, Ramis De Ayreflor Reyes S, John AA, Breiling E, O'Connor AM, Reis S, Shim JH, Shah AA, Srinivasan J, Farny NG. Nucleic acid aptamers protect against lead (Pb(II)) toxicity. N Biotechnol. 2024 Nov 25; 83:36-45.
Score: 0.008
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Mago A, Yang YS, Shim JH, John AA. Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies. Sensors (Basel). 2023 Sep 15; 23(18).
Score: 0.007
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Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, di Rocco M, Delai PLR, Diecidue RJ, Madhuri V, Cho TJ, Morhart R, Friedman CS, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D. Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles. Hum Gene Ther. 2022 08; 33(15-16):782-788.
Score: 0.007
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Shim JH, Lee HK, Chang EJ, Chae WJ, Han JH, Han DJ, Morio T, Yang JJ, Bothwell A, Lee SK. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10617-22.
Score: 0.007
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Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, Marquez SJ, White TE, Khan AG, Lorenz IC, Shim JH, Lee FS, Xu R, Greenblatt MB. SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nat Commun. 2021 07 29; 12(1):4611.
Score: 0.006
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Yoon DS, Lee KM, Cho S, Ko EA, Kim J, Jung S, Shim JH, Gao G, Park KH, Lee JW. Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage. Int J Med Sci. 2021; 18(15):3353-3360.
Score: 0.006
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Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nat Commun. 2020 11 11; 11(1):5704.
Score: 0.006
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Kim MJ, Min Y, Shim JH, Chun E, Lee KY. CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. Front Immunol. 2019; 10:2203.
Score: 0.006
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Son F, Umphred-Wilson K, Shim JH, Adoro S. Assessment of ESCRT Protein CHMP5 Activity on Client Protein Ubiquitination by Immunoprecipitation and Western Blotting. Methods Mol Biol. 2019; 1998:219-226.
Score: 0.005
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Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, Shim JH, Hameed M, Healey JH, Bostrom MP, Landau DA, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 10; 562(7725):133-139.
Score: 0.005
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Xu R, Yallowitz A, Qin A, Wu Z, Shin DY, Kim JM, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim JH, Glimcher LH, Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nat Med. 2018 06; 24(6):823-833.
Score: 0.005
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Kim Y, Zhang Z, Shim JH, Lee TS, Tung CH. A cell surface clicked navigation system to direct specific bone targeting. Bioorg Med Chem. 2018 02 01; 26(3):758-764.
Score: 0.005
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Min Y, Wi SM, Kang JA, Yang T, Park CS, Park SG, Chung S, Shim JH, Chun E, Lee KY. Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6. Cell Death Dis. 2016 07 28; 7(7):e2313.
Score: 0.005
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Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY. Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling. Cell Signal. 2015 Dec; 27(12):2524-33.
Score: 0.004
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Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY. TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-?B. J Biol Chem. 2014 Dec 19; 289(51):35205-14.
Score: 0.004
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Mi Wi S, Park J, Shim JH, Chun E, Lee KY. Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-?Bs in Toll-like receptor 4 signaling. Mol Biol Cell. 2015 Jan 01; 26(1):151-60.
Score: 0.004
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Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E, Lee KY. S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol. 2014 Feb; 34(3):510-21.
Score: 0.004
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Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY. Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal. Mol Endocrinol. 2013 Nov; 27(11):1958-68.
Score: 0.004
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Greenblatt MB, Shim JH, Glimcher LH. Mitogen-activated protein kinase pathways in osteoblasts. Annu Rev Cell Dev Biol. 2013; 29:63-79.
Score: 0.004
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Park TY, Kim SH, Shin YC, Lee NH, Lee RK, Shim JH, Glimcher LH, Mook-Jung I, Cheong E, Kim WK, Honda F, Morio T, Lim JS, Lee SK. Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release. 2013 Mar 28; 166(3):307-15.
Score: 0.004
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Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92.
Score: 0.003
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Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol. 2011 Jan; 13(1):59-65.
Score: 0.003
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Shin MJ, Shim JH, Lee JY, Chae WJ, Lee HK, Morio T, Park JH, Chang EJ, Lee SK. Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int J Hematol. 2010 Sep; 92(2):262-70.
Score: 0.003
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Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul; 120(7):2457-73.
Score: 0.003
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Kim SY, Jo HY, Kim MH, Cha YY, Choi SW, Shim JH, Kim TJ, Lee KY. H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activity. J Biol Chem. 2008 Nov 28; 283(48):33563-8.
Score: 0.003
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Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S. PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science. 2005 Apr 01; 308(5718):114-8.
Score: 0.002
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May MJ, Larsen SE, Shim JH, Madge LA, Ghosh S. A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem. 2004 Oct 29; 279(44):45528-39.
Score: 0.002