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Cole Haynes to Mitochondria

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This is a "connection" page, showing publications Cole Haynes has written about Mitochondria.
Cole Haynes
Connection Strength
13.638
Mitochondria
  1. Mallick A, Haynes CM. Methods to analyze the mitochondrial unfolded protein response (UPRmt). Methods Enzymol. 2024; 707:543-564.
    View in: PubMed
    Score: 0.732
  2. Kim S, Ramalho TR, Haynes CM. Regulation of proteostasis and innate immunity via mitochondria-nuclear communication. J Cell Biol. 2024 03 04; 223(3).
    View in: PubMed
    Score: 0.707
  3. Yang Q, Liu P, Anderson NS, Shpilka T, Du Y, Naresh NU, Li R, Zhu LJ, Luk K, Lavelle J, Zeinert RD, Chien P, Wolfe SA, Haynes CM. LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria. Nat Cell Biol. 2022 02; 24(2):181-193.
    View in: PubMed
    Score: 0.616
  4. Naresh NU, Haynes CM. Breaks in mitochondrial DNA rig the immune response. Nature. 2021 03; 591(7850):372-373.
    View in: PubMed
    Score: 0.576
  5. Shpilka T, Du Y, Yang Q, Melber A, Uma Naresh N, Lavelle J, Kim S, Liu P, Weidberg H, Li R, Yu J, Zhu LJ, Strittmatter L, Haynes CM. UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Nat Commun. 2021 01 20; 12(1):479.
    View in: PubMed
    Score: 0.572
  6. Anderson NS, Haynes CM. Folding the Mitochondrial UPR into the Integrated Stress Response. Trends Cell Biol. 2020 06; 30(6):428-439.
    View in: PubMed
    Score: 0.541
  7. Tremblay BP, Haynes CM. Mitochondrial distress call moves to the cytosol to trigger a response to stress. Nature. 2020 03; 579(7799):348-349.
    View in: PubMed
    Score: 0.538
  8. Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM. Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6146-6151.
    View in: PubMed
    Score: 0.502
  9. Melber A, Haynes CM. UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication. Cell Res. 2018 Mar; 28(3):281-295.
    View in: PubMed
    Score: 0.466
  10. Shpilka T, Haynes CM. The mitochondrial UPR: mechanisms, physiological functions and implications in ageing. Nat Rev Mol Cell Biol. 2018 02; 19(2):109-120.
    View in: PubMed
    Score: 0.459
  11. Lamech L, Haynes CM. Mitochondrial Sterol Oxidation Marks the Spot. Mol Cell. 2017 Nov 16; 68(4):641-642.
    View in: PubMed
    Score: 0.459
  12. Lamech L, Haynes CM. Vms1 Relieves a Mitochondrial Import Chokehold. Dev Cell. 2017 11 06; 43(3):259-260.
    View in: PubMed
    Score: 0.458
  13. Fiorese CJ, Haynes CM. Integrating the UPRmt into the mitochondrial maintenance network. Crit Rev Biochem Mol Biol. 2017 06; 52(3):304-313.
    View in: PubMed
    Score: 0.436
  14. Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM. Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. 2016 05 19; 533(7603):416-9.
    View in: PubMed
    Score: 0.412
  15. Lin YF, Haynes CM. Metabolism and the UPR(mt). Mol Cell. 2016 Mar 03; 61(5):677-682.
    View in: PubMed
    Score: 0.408
  16. Haynes CM. Cell biology: Surviving import failure. Nature. 2015 Aug 27; 524(7566):419-20.
    View in: PubMed
    Score: 0.392
  17. Schulz AM, Haynes CM. UPR(mt)-mediated cytoprotection and organismal aging. Biochim Biophys Acta. 2015 Nov; 1847(11):1448-56.
    View in: PubMed
    Score: 0.383
  18. Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Mol Cell. 2015 Apr 02; 58(1):123-33.
    View in: PubMed
    Score: 0.381
  19. Haynes C, Powell K. Cole Haynes: on the trail of mitochondrial dysfunction. J Cell Biol. 2015 Jan 19; 208(2):140-1.
    View in: PubMed
    Score: 0.377
  20. Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014 Dec 18; 516(7531):414-7.
    View in: PubMed
    Score: 0.369
  21. Haynes CM, Fiorese CJ, Lin YF. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol. 2013 Jul; 23(7):311-8.
    View in: PubMed
    Score: 0.332
  22. Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science. 2012 Aug 03; 337(6094):587-90.
    View in: PubMed
    Score: 0.315
  23. Baker BM, Nargund AM, Sun T, Haynes CM. Protective coupling of mitochondrial function and protein synthesis via the eIF2a kinase GCN-2. PLoS Genet. 2012; 8(6):e1002760.
    View in: PubMed
    Score: 0.315
  24. Pellegrino MW, Nargund AM, Haynes CM. Signaling the mitochondrial unfolded protein response. Biochim Biophys Acta. 2013 Feb; 1833(2):410-6.
    View in: PubMed
    Score: 0.310
  25. Baker BM, Haynes CM. Mitochondrial protein quality control during biogenesis and aging. Trends Biochem Sci. 2011 May; 36(5):254-61.
    View in: PubMed
    Score: 0.288
  26. Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci. 2010 Nov 15; 123(Pt 22):3849-55.
    View in: PubMed
    Score: 0.282
  27. Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell. 2010 Feb 26; 37(4):529-40.
    View in: PubMed
    Score: 0.269
  28. Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell. 2007 Oct; 13(4):467-80.
    View in: PubMed
    Score: 0.227
  29. Uma Naresh N, Kim S, Shpilka T, Yang Q, Du Y, Haynes CM. Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. Cell Rep. 2022 12 27; 41(13):111875.
    View in: PubMed
    Score: 0.163
  30. Haynes CM, Hekimi S. Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics. 2022 11 30; 222(4).
    View in: PubMed
    Score: 0.163
  31. Milstone ZJ, Saheera S, Bourke LM, Shpilka T, Haynes CM, Trivedi CM. Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis. Sci Adv. 2020 04; 6(15):eaax5150.
    View in: PubMed
    Score: 0.135
  32. Pires J, Haynes CM. Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria. Curr Biol. 2018 06 04; 28(11):R669-R671.
    View in: PubMed
    Score: 0.119
  33. Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M. Multiple Molecular Mechanisms Rescue mtDNA Disease in C.?elegans. Cell Rep. 2018 03 20; 22(12):3115-3125.
    View in: PubMed
    Score: 0.117
  34. Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 07; 21(6):1481-1494.
    View in: PubMed
    Score: 0.115
  35. Qureshi MA, Haynes CM, Pellegrino MW. The mitochondrial unfolded protein response: Signaling from the powerhouse. J Biol Chem. 2017 08 18; 292(33):13500-13506.
    View in: PubMed
    Score: 0.112
  36. Deng P, Haynes CM. Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. Semin Cancer Biol. 2017 12; 47:43-49.
    View in: PubMed
    Score: 0.111
  37. Deng P, Haynes CM. The mitokine quest(ion). Cell Res. 2016 12; 26(12):1265-1266.
    View in: PubMed
    Score: 0.107
  38. Pellegrino MW, Haynes CM. Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection. BMC Biol. 2015 Apr 03; 13:22.
    View in: PubMed
    Score: 0.096
  39. Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D. Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science. 2015 Mar 20; 347(6228):1374-7.
    View in: PubMed
    Score: 0.095
  40. Haynes CM, Titus EA, Cooper AA. Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell. 2004 Sep 10; 15(5):767-76.
    View in: PubMed
    Score: 0.046
  41. Ramalho T, Assis PA, Ojelabi O, Tan L, Carvalho B, Gardinassi L, Campos O, Lorenzi PL, Fitzgerald KA, Haynes C, Golenbock DT, Gazzinelli RT. Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells. Cell Metab. 2024 03 05; 36(3):484-497.e6.
    View in: PubMed
    Score: 0.044
  42. Dai CY, Ng CC, Hung GCC, Kirmes I, Hughes LA, Du Y, Brosnan CA, Ahier A, Hahn A, Haynes CM, Rackham O, Filipovska A, Zuryn S. ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Nat Cell Biol. 2023 08; 25(8):1111-1120.
    View in: PubMed
    Score: 0.042
  43. Jiang T, S?nchez-Rivera FJ, Soto-Feliciano YM, Yang Q, Song CQ, Bhuatkar A, Haynes CM, Hemann MT, Xue W. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Hepatology. 2021 07; 74(1):233-247.
    View in: PubMed
    Score: 0.037
  44. Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics. 2006 Sep; 174(1):229-39.
    View in: PubMed
    Score: 0.013
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