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Nathalie Cartier-Lacave MD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentNeurology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse education and training
    Paris Descartes University, Paris, , FranceMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Souchet B, Audrain M, Alves S, Fol R, Tada S, Orefice NS, Potier B, Dutar P, Billard JM, Cartier N, Braudeau J. Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer's Disease Predementia. J Prev Alzheimers Dis. 2022; 9(2):338-347. PMID: 35543008.
      Citations: 2     Fields:    Translation:HumansAnimals
    2. N?brega C, Concei??o A, Costa RG, Koppenol R, Sequeira RL, Nunes R, Carmo-Silva S, Marcelo A, Matos CA, Betuing S, Caboche J, Cartier N, Alves S. The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease. BMC Res Notes. 2020 Apr 10; 13(1):210. PMID: 32276655.
      Citations:    
    3. N?brega C, Mendon?a L, Marcelo A, Lamazi?re A, Tom? S, Despres G, Matos CA, Mechmet F, Langui D, den Dunnen W, de Almeida LP, Cartier N, Alves S. Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia. Acta Neuropathol. 2019 11; 138(5):837-858. PMID: 31197505.
      Citations:    
    4. Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun. 2019 03 18; 7(1):46. PMID: 30885273.
      Citations:    
    5. Cartier-Lacave N, Ali R, Yl?-Herttuala S, Kato K, Baetschi B, Lovell-Badge R, Naldini L, Thrasher A. Debate on Germline Gene Editing. Hum Gene Ther Methods. 2016 08; 27(4):135-42. PMID: 27529507.
      Citations: 3     Fields:    Translation:HumansCells
    6. Audrain M, Fol R, Dutar P, Potier B, Billard JM, Flament J, Alves S, Burlot MA, Dufayet-Chaffaud G, Bemelmans AP, Valette J, Hantraye P, D?glon N, Cartier N, Braudeau J. Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression. Mol Neurodegener. 2016 Jan 12; 11:5. PMID: 26759118.
      Citations:    
    7. Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, M?ller UC. Viral gene transfer of APPsa rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol. 2016 Feb; 131(2):247-266. PMID: 26538149.
      Citations:    
    8. Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Lapr?vote O, Bi?che I, Auzeil N, Potier MC, Dutar P, Korte M, Bu?e L, Blum D, Cartier N. Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum Mol Genet. 2015 Nov 01; 24(21):5965-76. PMID: 26358780.
      Citations:    
    9. Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bi?che I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N. CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease. Brain. 2015 Aug; 138(Pt 8):2383-98. PMID: 26141492.
      Citations:    
    10. Zerah M, Piguet F, Colle MA, Raoul S, Deschamps JY, Deniaud J, Gautier B, Toulgoat F, Bieche I, Laurendeau I, Sondhi D, Souweidane MM, Cartier-Lacave N, Moullier P, Crystal RG, Roujeau T, Sevin C, Aubourg P. Intracerebral Gene Therapy Using AAVrh.10-hARSA Recombinant Vector to Treat Patients with Early-Onset Forms of Metachromatic Leukodystrophy: Preclinical Feasibility and Safety Assessments in Nonhuman Primates. Hum Gene Ther Clin Dev. 2015 Jun; 26(2):113-24. PMID: 25758611.
      Citations: 39     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    11. Cartier N, Aubourg P. Hematopoietic stem cell transplantation and hematopoietic stem cell gene therapy in X-linked adrenoleukodystrophy. Brain Pathol. 2010 Jul; 20(4):857-62. PMID: 20626747.
      Citations: 50     Fields:    Translation:HumansCells
    12. Cartier N, Hacein-Bey-Abina S, Von Kalle C, Bougn?res P, Fischer A, Cavazzana-Calvo M, Aubourg P. [Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector]. Bull Acad Natl Med. 2010 Feb; 194(2):255-64; discussion 264-8. PMID: 21166117.
      Citations: 10     Fields:    Translation:HumansCells
    13. Sevin C, Cartier-Lacave N, Aubourg P. Gene therapy in metachromatic leukodystrophy. Int J Clin Pharmacol Ther. 2009; 47 Suppl 1:S128-31. PMID: 20040324.
      Citations: 1     Fields:    Translation:HumansAnimals
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