Kuang Shen to Monomeric GTP-Binding Proteins
This is a "connection" page, showing publications Kuang Shen has written about Monomeric GTP-Binding Proteins.
Connection Strength
7.898
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Tettoni SD, Egri SB, Doxsey DD, Veinotte K, Ouch C, Chang JY, Song K, Xu C, Shen K. Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure. 2023 09 07; 31(9):1065-1076.e5.
Score: 0.823
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Doxsey DD, Tettoni SD, Egri SB, Shen K. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells. J Biol Chem. 2023 07; 299(7):104880.
Score: 0.816
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Doxsey DD, Shen K. Purification and biochemical characterization of the Rag GTPase heterodimer. Methods Enzymol. 2022; 675:131-158.
Score: 0.773
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Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022 05 19; 82(10):1836-1849.e5.
Score: 0.752
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Doxsey DD, Veinotte K, Shen K. A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae. Small GTPases. 2022 01; 13(1):327-334.
Score: 0.740
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Egri SB, Shen K. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids. J Biol Chem. 2021 07; 297(1):100861.
Score: 0.712
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Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell. 2019 11 27; 179(6):1319-1329.e8.
Score: 0.638
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Shen K, Valenstein ML, Gu X, Sabatini DM. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. J Biol Chem. 2019 02 22; 294(8):2970-2975.
Score: 0.603
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Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9545-9550.
Score: 0.588
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Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. 2018 04 05; 556(7699):64-69.
Score: 0.570
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Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Mol Cell. 2017 Nov 02; 68(3):552-565.e8.
Score: 0.553
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Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleiner?schkamp F, Oh J, Godefroid N, Eltan M, G?ran T, Burtey S, Parotte MC, K?nig J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altm?ller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF. mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol. 2021 11; 32(11):2885-2899.
Score: 0.182
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Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94.
Score: 0.114
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Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442.
Score: 0.033