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Naturally Occurring Off-Switches for CRISPR-Cas9.
Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.
A Broad-Spectrum Inhibitor of CRISPR-Cas9.
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo.
Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.
Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance.
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
An engineered ScCas9 with broad PAM range and high specificity and activity.
Genome-wide detection and analysis of CRISPR-Cas off-targets.
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.
CRISPR Cas Systems