Rene Maehr PHD
|Institution||University of Massachusetts Medical School|
|Department||Program in Molecular Medicine|
|Address||University of Massachusetts Medical School|
368 Plantation Street, AS7-2057
Worcester MA 01605
|Institution||UMMS - School of Medicine|
|Department||RNA Therapeutics Institute|
|Institution||UMMS - Graduate School of Biomedical Sciences|
|Department||Interdisciplinary Graduate Program|
Type 1 Diabetes (T1D) is the result of an autoimmune destruction of insulin producing, pancreatic beta cells. The events leading to the disease have usually occurred long before diagnosis and are based on complex interactions between genes and the environment. The currently available rodent models for T1D can only represent a limited number of patients leaving open the question how many different types of T1D exist. To overcome these difficulties and expand our understanding of T1D and other diseases targeting the immune system we are building in vitro models using human pluripotent stem cells. In those stem cell-based model systems genetic and developmental aspects of the disease can be elucidated. The long-term goal is to recapitulate the disease in a patient-specific manner and to identify novel treatment strategies.
A rotation project is available
A postdoctoral position is available
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