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    Evgeny I Rogaev PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPsychiatry
    AddressUniversity of Massachusetts Medical School
    303 Belmont Street
    Worcester MA 01605
    Phone508-856-8438
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBrudnick Neuropsychiatric Research Institute

        Overview 
        Narrative

        Academic Background

        Education

        Moscow State University, Biological Department, School of Genetics

        Master D. 1983
        Ph.D. 1988
        Dr.Sci. 1996

        Work History

        Scientific Researcher, Leading Researcher
        National Mental Research Center
        Russian Academy of Medical Science
        1985-1990
        Visiting Scientist, Visiting Professor (U of Toronto) 1992-1995, 2001
        Head, Laboratory of Molecular Brain Genetics
        Research Center of Mental Health
        Russian Academy of Medical Sciences
        1990- present
        Professor of Psychiatry, BNRI, UMASS Medical School 2002- present

        Molecular genetic mechanisms of neuropsychiatric diseases and dementia
        Mapping and Positional cloning of genes for human pathologies

        Photo: Evgeny Rogaev, PhD, DrSciOur research is focused on the identification of genes and cellular proteins that play a critical role in normal and pathological aspects of human behavior. To identify such genes and proteins we first use the strategies of linkage, genetic association analysis and positional cloning to isolate the mutant or polymorphic genes underlying the human diseases. We then develop functional assays to express these genes in vitro and in vivo to study their normal and pathogenic functions.

        We are interested also in the study of evolutionary aspects of human populations, genome and specific genes in order to elucidate the phenomenon of some behavioral disorders prevalent in humankind.

        Alzheimer's disease, schizophrenia and depression are three of the most common mental disorders and our primary interest.

        Alzheimer's Disease

        The mutations in human presenilin 1 and presenilin 2 genes, which we and our colleagues described previously, are a major cause of familial early-onset Alzheimer's disease. The AD-mutations in the presenilins are supposed to enhance its proteolysis-associated activity, that in turn may result in elevated amyloid precursor protein cleavage and production of neurotoxic beta amyloid derivates. However, other "non-amyloid" mechanisms of pathogenic effects of presenilins have not yet been ruled out. The role of presenilins in most common "non-familial" AD cases, and cellular factors or chemical compounds which may modulate the activity of presenilins, are still unclear. Our studies search for factors that may regulate presenilin genes and interact with presenilin proteins. We search for population variations and modifications in promoters of presenilin 1 and presenilin 2 genes and measure the transcriptional activity of variable regulatory regions of presenilins. The potential exogenous and endogenous inhibitors or repressors of these elements are tested in neural human or rat cells. We also search for families of proteins that interact directly with presenilins or their targets (e.g., Amyloid Precursor Protein and Notch-receptors) and which may serve as modulators of presenilin mediated proteolysis. These studies will contribute to understanding of fundamental mechanisms of inter- and intra-cellular signaling and also provide potential targets for treatment of Alzheimer's disease neuro-degeneration.

        More than 50% of AD have no association with mutations in encoding regions of presenilins and other known AD -genes (ApoE,APP). Thus, there must be other AD genes yet to be discovered. In order to identify such genes, we combine the methods of genetic association and linkage analysis in families and population groups of late-onset AD patients and age-matched non-demented individuals. We test the single nucleotide polymorphisms (SNPs) in several selected chromosomal loci to define the narrow genomic region and ultimately identify novel genes associated with AD.

        Schizophrenia and Depression

        The molecular-genetic mechanisms and genes for schizophrenia or affective disorders remains to be elusive. We are collecting large samples of schizophrenia and affective disorders from ethnically defined populations. The identification of specific SNPs haplotypes and linkage disequilibrium analysis for a few candidate loci and genes are currently of our particular interest. A MassARRAY MALDI system will be used for fine mapping of these loci. Recently two novel candidate-genes for schizophrenia have been isolated from two chromosomal loci by testing of multiple polymorphic markers in two population samples. These primary data are to be replicated in the genetic study of other population samples. To elucidate the biological significance of the candidate-genes found by genetic approach, the study of effects of up- and down regulation of the candidate- genes on neuroplasticity and neurotransmition signaling will be undertaken.

        Other Diseases

        It is assumed that common diseases represent mainly polygenic or multifactorial diseases. The identification of the susceptible genes for such diseases is rather complicated. However, familial (Mendelian) transmission of diseases which may be clinically similar to common phenotypes is observed in rare families. We are interested in identifying and studying such families. Isolation of the disease genes in these rare families may help to elucidate the molecular mechanisms for more common forms of the human diseases.

        We use unique resources in several genetic isolates and limited human populations. Large pedigrees of human families with autosomal-dominant and autosomal-recessive diseases with unknown gene defects are being collected . Currently, we apply strategies of positional cloning and direct screening of candidate-genes for variety of human diseases, including eg., morbid obesity with hyperphagia, a specific case of premature aging, eye-diseases, alopecia (baldness) and others.



        Post Docs

        A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Rykalina VN, Shadrin AA, Amstislavskiy VS, Rogaev EI, Lehrach H, Borodina TA. Exome Sequencing from Nanogram Amounts of Starting DNA: Comparing Three Approaches. PLoS One. 2014; 9(7):e101154.
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        2. Moroz LL, Kocot KM, Citarella MR, Dosung S, Norekian TP, Povolotskaya IS, Grigorenko AP, Dailey C, Berezikov E, Buckley KM, Ptitsyn A, Reshetov D, Mukherjee K, Moroz TP, Bobkova Y, Yu F, Kapitonov VV, Jurka J, Bobkov YV, Swore JJ, Girardo DO, Fodor A, Gusev F, Sanford R, Bruders R, Kittler E, Mills CE, Rast JP, Derelle R, Solovyev VV, Kondrashov FA, Swalla BJ, Sweedler JV, Rogaev EI, Halanych KM, Kohn AB. The ctenophore genome and the evolutionary origins of neural systems. Nature. 2014 Jun 5; 510(7503):109-14.
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        3. Ponomareva N, Andreeva T, Protasova M, Shagam L, Malina D, Goltsov A, Fokin V, Mitrofanov A, Rogaev E. Age-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults. Front Aging Neurosci. 2013; 5:86.
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        4. Lukiw WJ, Andreeva TV, Grigorenko AP, Rogaev EI. Studying micro RNA Function and Dysfunction in Alzheimer's Disease. Front Genet. 2012; 3:327.
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        5. Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 2012; 10(11):e1001427.
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        6. Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S. Epigenetics in the human brain. Neuropsychopharmacology. 2013 Jan; 38(1):183-97.
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        7. Rogaev EI. Genomics of behavioral diseases. Front Genet. 2012; 3:45.
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        8. Selezneva ND, Roshchina IF, Gavrilova SI, Fedorova IaB, Gantman MV, Korovaitseva GI, Kunizheva SS, Rogaev EI. [Mental disorders of cognitive and non-cognitive spectrum in the first-degree relatives of patients with Alzheimer's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(10):8-13.
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        9. Ponomareva NV, Goltsov AY, Kunijeva SS, Scheglova NS, Malina DD, Mitrofanov AA, Boikova TI, Rogaev EI. Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults. Neurobiol Aging. 2012 Apr; 33(4):839.e11-21.
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        10. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI. Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action. Biochemistry (Mosc). 2010 Sep; 75(9):1088-97.
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        11. Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophr Bull. 2012 May; 38(3):433-43.
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        12. Golenkina SA, Gol'tsov AIu, Kuznetsova IL, Grigorenko AP, Andreeva TV, Reshetov DA, Kunizheva SS, Shagam LI, Morozova IIu, Goldenkova-Pavlova IV, Shimshilashvili Kh, Viacheslavova AO, Faskhutdinova G, Gareeva AÉ, Zainullina AG, Khusnutdinova ÉK, Puzyrev VP, Stepanov VA, Kolotvin AV, Samokhodskaia LM, Selezneva ND, Gavrilova SI, Rogaev EI. [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations]. Mol Biol (Mosk). 2010 Jul-Aug; 44(4):620-6.
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        13. Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, King RJ, Lin AA, Chow CE, Semino O, Battaglia V, Kutuev I, Järve M, Chaubey G, Ayub Q, Mohyuddin A, Mehdi SQ, Sengupta S, Rogaev EI, Khusnutdinova EK, Pshenichnov A, Balanovsky O, Balanovska E, Jeran N, Augustin DH, Baldovic M, Herrera RJ, Thangaraj K, Singh V, Singh L, Majumder P, Rudan P, Primorac D, Villems R, Kivisild T. Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a. Eur J Hum Genet. 2010 Apr; 18(4):479-84.
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        14. Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK. Genotype analysis identifies the cause of the "royal disease". Science. 2009 Nov 6; 326(5954):817.
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        15. Grigorenko AP, Borinskaya SA, Yankovsky NK, Rogaev EI. Achievements and peculiarities in studies of ancient DNA and DNA from complicated forensic specimens. Acta Naturae. 2009 Oct; 1(3):58-69.
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        16. Järve M, Zhivotovsky LA, Rootsi S, Help H, Rogaev EI, Khusnutdinova EK, Kivisild T, Sanchez JJ. Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit. PLoS One. 2009; 4(9):e7276.
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        17. Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, Mohyuddin A, Gurwitz D, Mehdi SQ, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK. Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. Ann Hum Genet. 2009 May; 73(Pt 3):335-45.
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        18. Rogaev EI, Grigorenko AP, Moliaka YK, Faskhutdinova G, Goltsov A, Lahti A, Hildebrandt C, Kittler EL, Morozova I. Genomic identification in the historical case of the Nicholas II royal family. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5258-63.
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        19. Borinskaya S, Kal'ina N, Marusin A, Faskhutdinova G, Morozova I, Kutuev I, Koshechkin V, Khusnutdinova E, Stepanov V, Puzyrev V, Yankovsky N, Rogaev E. Distribution of the alcohol dehydrogenase ADH1B*47His allele in Eurasia. Am J Hum Genet. 2009 Jan; 84(1):89-92; author reply 92-4.
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        20. Rogaev EI, Borinskaia SA, Islamgulov DV, Grigorenko AP. [Human microRNA in norm and pathology]. Mol Biol (Mosk). 2008 Sep-Oct; 42(5):751-64.
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        21. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet. 2008 Oct 1; 17(19):3030-42.
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        22. Borinskaia SA, Kal'ina NR, Sanina ED, Kozhekbaeva ZhM, Gupalo EIu, Garmash IV, Ogurtsov PP, Parshukova ON, Boiko SG, Veselovskii EM, Vershubskaia GG, Kozlov AI, Rogaev EI, Iankovskii NK. [Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries]. Genetika. 2007 Oct; 43(10):1434-40.
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        23. Plotnikova OV, Kondrashov FA, Vlasov PK, Grigorenko AP, Ginter EK, Rogaev EI. Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state. Am J Hum Genet. 2007 Jul; 81(1):32-43.
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        24. Burmistrova OA, Goltsov AY, Abramova LI, Kaleda VG, Orlova VA, Rogaev EI. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry (Mosc). 2007 May; 72(5):578-82.
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        25. Grigorenko AP, Rogaev EI. [Molecular basics of Alzheimer's disease]. Mol Biol (Mosk). 2007 Mar-Apr; 41(2):331-45.
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        26. Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiol Aging. 2008 Jun; 29(6):819-27.
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        27. Kazantseva A, Goltsov A, Zinchenko R, Grigorenko AP, Abrukova AV, Moliaka YK, Kirillov AG, Guo Z, Lyle S, Ginter EK, Rogaev EI. Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH. Science. 2006 Nov 10; 314(5801):982-5.
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        28. Goltsov AY, Loseva JG, Andreeva TV, Grigorenko AP, Abramova LI, Kaleda VG, Orlova VA, Moliaka YK, Rogaev EI. Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. Mol Psychiatry. 2006 Apr; 11(4):325-6.
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        29. Rogaev EI, Moliaka YK, Malyarchuk BA, Kondrashov FA, Derenko MV, Chumakov I, Grigorenko AP. Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius. PLoS Biol. 2006 Mar; 4(3):e73.
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        30. Rogaev EI. Small RNAs in human brain development and disorders. Biochemistry (Mosc). 2005 Dec; 70(12):1404-7.
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        31. Golimbet VE, Lebedeva IS, Gritsenko IK, Korovaitseva GI, Alfimova MV, Lezheiko TV, Abramova LI, Kaleda VG, Ebshtein RP, Rogaev EI. [A study of some genes related to serotoninergic and dopaminergic systems and auditory evoked-potentials (P300) in patients with schizophrenia and spectrum disorders and their first-degree relatives]. Zh Nevrol Psikhiatr Im S S Korsakova. 2005; 105(10):35-41.
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        32. Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B, Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, Ravid R, Konietzko U, Hegi T, Pasch T, Jung H, Braak H, Amouyel P, Rogaev EI, Hardy J, Hock C, Nitsch RM. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. Neurodegener Dis. 2005; 2(5):233-41.
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        33. Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14955-60.
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        34. Chen F, Wollmer MA, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J. Role for glyoxalase I in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7687-92.
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        35. Golimbet VE, Alfimova MV, Shchebatykh TV, Abramova LI, Kaleda VG, Rogaev EI. Serotonin transporter polymorphism and depressive-related symptoms in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1; 126B(1):1-7.
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        36. Moliaka YK, Grigorenko A, Madera D, Rogaev EI. Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. FEBS Lett. 2004 Jan 16; 557(1-3):185-92.
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        37. Bobrysheva IV, Grigorenko AP, Novosadova EV, Kal'ina NR, Arsenyeva EL, Grivennikov IA, Tarantul VZ, Rogaev EI. Effects of human presenilin 1 isoforms on proliferation and survival of rat pheochromocytoma cell line PC12. Biochemistry (Mosc). 2003 Jun; 68(6):611-7.
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        38. Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Gene insertion and deletion polymorphism in the serotonin transporter gene and personality traits measured by MMPI]. Genetika. 2003 Apr; 39(4):534-9.
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        39. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D, Ouelette G, Realson J. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13675-80.
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        40. Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI. Novel class of polytopic proteins with domains associated with putative protease activity. Biochemistry (Mosc). 2002 Jul; 67(7):826-35.
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        41. Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Allele polymorphism of the serotonin transporter gene and clinical heterogeneity of depressive disorders]. Genetika. 2002 May; 38(5):671-7.
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        42. Maliarchuk BA, Derenko MV, Denisova GA, Nassiri MR, Rogaev EI. [Mitochondrial DNA polymorphism in populations of the Caspian region and southeastern Europe]. Genetika. 2002 Apr; 38(4):534-8.
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        43. Iatsyshina SB, Moliaka IuK, Karpova SK, Chekhranova MK, Popova IuP, Grigorian ON, Pankov IuA, Rogaev EI. [Study of the association between constitutional exogenous obesity and polymorphism of the apolipoprotein B gene]. Genetika. 2002 Feb; 38(2):285-8.
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        44. Pankov IuA, Iatsyshina SB, Karpova SK, Chekhranova MK, Popova IuP, Grigorian ON, Rogaev EI. [Screening of mutations in genes of pro-opiomelanocortin in patients with constitutional exogenous obesity]. Vopr Med Khim. 2002 Jan-Feb; 48(1):121-30.
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        45. Nicolaou M, Song YQ, Sato CA, Orlacchio A, Kawarai T, Medeiros H, Liang Y, Sorbi S, Richard E, Rogaev EI, Moliaka Y, Bruni AC, Jorge R, Percy M, Duara R, Farrer LA, St Georg-Hyslop P, Rogaeva EA. Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease. Neurogenetics. 2001 Oct; 3(4):203-6.
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        46. Maliarchuk BA, Denisova GA, Derenko MV, Rogaev EI, Vlasenko LV, Zhukova SG. [Variability in mitochondrial DNA in Russian inhabitants from Krasnodar Krai, Belgorod and the lower Novgorod region]. Genetika. 2001 Oct; 37(10):1411-6.
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        47. Rogaeva EA, Fafel KC, Song YQ, Medeiros H, Sato C, Liang Y, Richard E, Rogaev EI, Frommelt P, Sadovnick AD, Meschino W, Rockwood K, Boss MA, Mayeux R, St George-Hyslop P. Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations. Neurology. 2001 Aug 28; 57(4):621-5.
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        48. Ginter EK, Kirillov AG, Rogaev EI. [Autosomal-dominant osteopetrosis in Chuvashiya]. Genetika. 2001 Aug; 37(8):1152-5.
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        49. Korovaitseva GI, Shcherbatykh TV, Selezneva NV, Gavrilova SI, Golimbet VE, Voskresenskaia NI, Rogaev EI. [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. 2001 Apr; 37(4):529-35.
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        50. Shcherbatykh TV, Kiryanov SA, Korovaitseva GI, Selezneva ND, Voskresenskaya NI, Golimbet VE, Farrer L, Gavrilova SI, Rogaev EI. The angiotensin-converting enzyme gene as a possible risk or protective factor in Alzheimer's disease. Neurosci Behav Physiol. 2001 Mar-Apr; 31(2):179-81.
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        51. Lukiw WJ, Gordon WC, Rogaev EI, Thompson H, Bazan NG. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. Neuroreport. 2001 Jan 22; 12(1):53-7.
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        52. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 2000 Sep 7; 407(6800):48-54.
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        53. Farrer LA, Sherbatich T, Keryanov SA, Korovaitseva GI, Rogaeva EA, Petruk S, Premkumar S, Moliaka Y, Song YQ, Pei Y, Sato C, Selezneva ND, Voskresenskaya S, Golimbet V, Sorbi S, Duara R, Gavrilova S, St George-Hyslop PH, Rogaev EI. Association between angiotensin-converting enzyme and Alzheimer disease. Arch Neurol. 2000 Feb; 57(2):210-4.
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        54. Rogaev EI. [Genetic factors and a polygenic model of Alzheimer's disease]. Genetika. 1999 Nov; 35(11):1558-71.
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        55. Rogaev EI, Zinchenko RA, Dvoryachikov G, Sherbatich T, Ginter EK. Total hypotrichosis: genetic form of alopecia not linked to hairless gene. Lancet. 1999 Sep 25; 354(9184):1097-8.
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        56. Korovaitseva GI, Premkumar S, Grigorenko A, Molyaka Y, Galimbet V, Selezneva N, Gavrilova SI, Farrer LA, Rogaev EI. Alpha-2 macroglobulin gene in early- and late-onset Alzheimer disease. Neurosci Lett. 1999 Aug 20; 271(2):129-31.
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        57. Shcherbatykh TV, Kir'ianov SA, Korovaitsev GI, Selezneva ND, Voskresenskaia NI, Golimbet VE, Farrr L, Gavrilova SI, Rogaev EI. [Angiotensin-converting enzyme gene as a possible risk factor or protective factor in Alzheimer's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 1999; 99(9):51-2.
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        58. Rogaev EI. [Genetic basis for Alzheimer's disease and other dementias and prospects of molecular diagnosis]. Vestn Ross Akad Med Nauk. 1999; (1):33-9.
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        59. Solov'ev IV, Iurov IuB, Vorsanova SG, Marcais B, Rogaev EI, Kapanadze BI, Brodianskii VM, Iankovskii NK, Roizes G. [Study of alpha-satellite DNA in cosmid libraries, specific for chromosomes 13, 21, and 22, using fluorescence in situ hybridization]. Genetika. 1998 Nov; 34(11):1470-9.
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        60. Rogaev EI. [Presenilins: detection and characterization of Alzheimer's disease genes]. Mol Biol (Mosk). 1998 Jan-Feb; 32(1):71-83.
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        61. Korovaitseva GI, Bukina A, Farrer LA, Rogaev EI. Presenilin polymorphisms in Alzheimer's disease. Lancet. 1997 Sep 27; 350(9082):959.
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        62. Kir'ianov SA, Rogaev EI. [Rapid isolation of CpG-islands by PCR-amplification of genomic DNA fragments using a "CpG-enriched" primer]. Genetika. 1997 Jul; 33(7):891-8.
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        63. Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics. 1997 Mar 15; 40(3):415-24.
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        64. Boulianne GL, Livne-Bar I, Humphreys JM, Liang Y, Lin C, Rogaev E, St George-Hyslop P. Cloning and characterization of the Drosophila presenilin homologue. Neuroreport. 1997 Mar 3; 8(4):1025-9.
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        65. Igarashi S, Takiyama Y, Cancel G, Rogaeva EA, Sasaki H, Wakisaka A, Zhou YX, Takano H, Endo K, Sanpei K, Oyake M, Tanaka H, Stevanin G, Abbas N, Dürr A, Rogaev EI, Sherrington R, Tsuda T, Ikeda M, Cassa E, Nishizawa M, Benomar A, Julien J, Weissenbach J, Wang GX, Agid Y, St George-Hyslop PH, Brice A, Tsuji S. Intergenerational instability of the CAG repeat of the gene for Machado-Joseph disease (MJD1) is affected by the genotype of the normal chromosome: implications for the molecular mechanisms of the instability of the CAG repeat. Hum Mol Genet. 1996 Jul; 5(7):923-32.
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        66. Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G, Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME, Clerget-Darpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T, Lannfelt L, Rommens JM, St George-Hyslop PH. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet. 1996 Jul; 5(7):985-8.
          View in: PubMed
        67. Rogaev EI, Rogaeva EA, Korovaitseva GI, Farrer LA, Petrin AN, Keryanov SA, Turaeva S, Chumakov I, St George-Hyslop P, Ginter EK. Linkage of polymorphic congenital cataract to the gamma-crystallin gene locus on human chromosome 2q33-35. Hum Mol Genet. 1996 May; 5(5):699-703.
          View in: PubMed
        68. Trower MK, Orton SM, Purvis IJ, Sanseau P, Riley J, Christodoulou C, Burt D, See CG, Elgar G, Sherrington R, Rogaev EI, St George-Hyslop P, Brenner S, Dykes CW. Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus) Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4):1366-9.
          View in: PubMed
        69. Golimbet VE, Ovchinnikov IV, Voskresenskaia NI, Iurov IuB, Rogaev EI, Doronina OA, Maksunova IV. [The search for a mutation in the gene coding the beta-amyloid protein precursor gene in patients with Alzheimer-type dementias]. Zh Nevrol Psikhiatr Im S S Korsakova. 1996; 96(1):75-8.
          View in: PubMed
        70. Tsuda T, Chi H, Liang Y, Rogaeva EA, Sherrington R, Levesque G, Ikeda M, Rogaev EI, Pollen D, Freedman M, et al. Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases. Neurosci Lett. 1995 Dec 8; 201(2):188-90.
          View in: PubMed
        71. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 1995 Aug 31; 376(6543):775-8.
          View in: PubMed
        72. Sorbi S, Nacmias B, Forleo P, Piacentini S, Sherrington R, Rogaev E, St George Hyslop P, Amaducci L. Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease. Lancet. 1995 Aug 12; 346(8972):439-40.
          View in: PubMed
        73. Takiyama Y, Igarashi S, Rogaeva EA, Endo K, Rogaev EI, Tanaka H, Sherrington R, Sanpei K, Liang Y, Saito M, et al. Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease. Hum Mol Genet. 1995 Jul; 4(7):1137-46.
          View in: PubMed
        74. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995 Jun 29; 375(6534):754-60.
          View in: PubMed
        75. Rogaev EI, Lukiw WJ, Lavrushina O, Rogaeva EA, St George-Hyslop PH. The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain. Genomics. 1994 Jul 15; 22(2):340-7.
          View in: PubMed
        76. St George-Hyslop P, Rogaeva E, Huterer J, Tsuda T, Santos J, Haines JL, Schlumpf K, Rogaev EI, Liang Y, McLachlan DR, et al. Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14. Am J Hum Genet. 1994 Jul; 55(1):120-5.
          View in: PubMed
        77. Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Ann Neurol. 1994 Jul; 36(1):97-100.
          View in: PubMed
        78. Lukiw WJ, Rogaev EI, Wong L, Vaula G, McLachlan DR, St George Hyslop P. Protein-DNA interactions in the promoter region of the amyloid precursor protein (APP) gene in human neocortex. Brain Res Mol Brain Res. 1994 Mar; 22(1-4):121-31.
          View in: PubMed
        79. Rogaev EI, Rogaeva EA, Ginter EK, Korovaitseva GI, Farrer L, Shlenskii AB, Prytkov AN, St George-Hyslop P, Mordovtsev VN. [Mapping the gene for palmoplantar hyperkeratosis (thylosis) to chromosome 17 in the 17q12-q24 region]. Genetika. 1994 Mar; 30(3):326-9.
          View in: PubMed
        80. St George-Hyslop P, McLachlan DC, Tsuda T, Rogaev E, Karlinsky H, Lippa CF, Pollen D, Tuda T. Alzheimer's disease and possible gene interaction. Science. 1994 Jan 28; 263(5146):537.
          View in: PubMed
        81. Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N, Liang Y, Mortilla M, Amaducci L, Bergamini L, Bruni AC, Foncin JF, Macciardi F, Montesi M, Sorbi S, Rainero I, Pinessi L, Polinsky RJ, Frommelt P, Duara R, Lopez R, Pollen D, Gusella JF, Tanzi R, MacLachlan D, Crapper D, St George-Hyslop PH, et al. Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology. 1993 Nov; 43(11):2275-9.
          View in: PubMed
        82. Rogaev EI, Rogaeva EA, Ginter EK, Korovaitseva GI, Farrer LA, Shlensky AB, Pritkov AN, Mordovtsev VN, St George-Hyslop PH. Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. Nat Genet. 1993 Oct; 5(2):158-62.
          View in: PubMed
        83. Rogaev EI, Korovaitseva GI, Ginter EK, Prytkov AN, Maksudova KhA. [Mapping of the dominant gene of hyperkeratosis palmaris et plantaris in man]. Genetika. 1993 Jul; 29(7):1180-5.
          View in: PubMed
        84. Tupler R, Rogaeva E, Vaula G, Mortilla M, Lukiw W, Liang Y, Hancock R, Rogaev E, St George-Hyslop P. A highly informative microsatellite repeat polymorphism in intron 1 of the human amyloid precursor protein (APP) gene. Hum Mol Genet. 1993 May; 2(5):620.
          View in: PubMed
        85. Ginter EK, Rogaev EI, Korovaitseva GI, Turaeva ShM, Petrin AN, Spitsyn VA, Tarlycheva LV. [Further analysis of location of the gene for inborn dominant Nochurli cataract]. Genetika. 1993 Apr; 29(4):670-4.
          View in: PubMed
        86. Rogaev E, Rogaeva E, Lukiw WJ, Vaula G, Liang Y, Hancock R, McLachlan DC, St George-Hyslop PH. An informative microsatellite repeat polymorphism in the human neurofilament light polypeptide (NEFL) gene. Hum Mol Genet. 1992 Dec; 1(9):781.
          View in: PubMed
        87. St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin JF, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K, Tanzi R, Tsuda T, Farrer L, Cantu JM, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet. 1992 Dec; 2(4):330-4.
          View in: PubMed
        88. Rogaev EI, Keryanov SA. Unusual variability of the complex dinucleotide repeat block at the SPN locus. Hum Mol Genet. 1992 Nov; 1(8):657.
          View in: PubMed
        89. Rogaev EI, Keryanov SA, Malyako YK. Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci. Hum Mol Genet. 1992 Jul; 1(4):285.
          View in: PubMed
        90. Rogaev EI, Iurov IuB, Iakovlev AG. [Molecular genetics of the human brain]. Vestn Ross Akad Med Nauk. 1992; (8):11-6.
          View in: PubMed
        91. Ginter EK, Petrin AN, Spitsyn VA, Rogaev EI. [An attempt to locate the gene for congenital cataracts using linkage analysis]. Genetika. 1991 Oct; 27(10):1840-9.
          View in: PubMed
        92. Rogaev EI, Shlenskii AB. Individual-specific patterns of human variable genomic regions detected by a DNA probe from the HIV-1 env gene. Biomed Sci. 1991; 2(3):311-3.
          View in: PubMed
        93. Rogaev EI. Simple human DNA-repeats associated with genomic hypervariability, flanking the genomic retroposons and similar to retroviral sites. Nucleic Acids Res. 1990 Apr 11; 18(7):1879-85.
          View in: PubMed
        94. Rogaev EI, Shlensky AB. The genomic DNA phi Fd103 probe is sensitive marker for detection of human hypervariable genomic regions. Nucleic Acids Res. 1990 Feb 25; 18(4):1081.
          View in: PubMed
        95. Rogaev EI. Two novel human DNA tandem repeat families from the hypervariable DNA probe homologous to human apolipoprotein CII-gene intron and D. virilis satellite. Nucleic Acids Res. 1989 Feb 11; 17(3):1246.
          View in: PubMed
        96. Zaitsev IZ, Rogaev EI. [Structural analysis of alphoid DNA of primates. I. Heterogeneity of nucleotide sequence of alphoid repeats in human DNA]. Mol Biol (Mosk). 1986 May-Jun; 20(3):663-73.
          View in: PubMed
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