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    Babs R Soller PhD

    TitleProfessor Emeritus
    InstitutionUniversity of Massachusetts Medical School
    DepartmentAnesthesiology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-5904
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentSurgery
      DivisionCardiothoracic Surgery

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

        Overview 
        Narrative

        Academic Background

        Ph.D. (Physical Chemistry), Princeton

        Photo: Babs Soller, Ph.D.

        We are exploring the application of optical spectroscopy for the noninvasive measurement of blood and tissue chemistry, ultimately to be able to perform chemical analysis and diagnosis without removing a sample from the patient. We are currently investigating the use of near infrared spectroscopy in combination with in-vivo chemometric techniques to determine tissue pH, tissue oxygen tension and blood hematocrit. We are also interested in the application of this technology in the triage and treatment of trauma patients.



        Rotation Projects



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Soller B, Srikiatkachorn A, Zou F, Rothman AL, Yoon IK, Gibbons RV, Kalayanarooj S, Thomas SJ, Green S. Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever. BMC Infect Dis. 2014; 14(1):396.
          View in: PubMed
        2. Soller B, Smith C, Zou F, Ellerby GE, Prince MD, Sondeen JL. Investigation of Noninvasive Muscle pH and Oxygen Saturation During Uncontrolled Hemorrhage and Resuscitation in Swine. Shock. 2014 Jul; 42(1):44-51.
          View in: PubMed
        3. Soller BR, Zou F, Ryan KL, Rickards CA, Ward K, Convertino VA. Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: a review. J Trauma Acute Care Surg. 2012 Aug; 73(2 Suppl 1):S106-11.
          View in: PubMed
        4. Lee SM, Clarke MS, O'Connor DP, Stroud L, Ellerby GE, Soller BR. Near infrared spectroscopy-derived interstitial hydrogen ion concentration and tissue oxygen saturation during ambulation. Eur J Appl Physiol. 2011 Aug; 111(8):1705-14.
          View in: PubMed
        5. Ward KR, Tiba MH, Ryan KL, Filho IP, Rickards CA, Witten T, Soller BR, Ludwig DA, Convertino VA. Oxygen transport characterization of a human model of progressive hemorrhage. Resuscitation. 2010 Aug; 81(8):987-93.
          View in: PubMed
        6. Soller BR, Ryan KL, Rickards CA, Cooke WH, Yang Y, Soyemi OO, Crookes BA, Heard SO, Convertino VA. Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans. Crit Care Med. 2008 Jan; 36(1):176-82.
          View in: PubMed
        7. Soller BR, Yang Y, Lee SM, Wilson C, Hagan RD. Noninvasive determination of exercise-induced hydrodgen ion threshold through direct optical measurement. J Appl Physiol (1985). 2008 Mar; 104(3):837-44.
          View in: PubMed
        8. Soller BR, Yang Y, Soyemi OO, Ryan KL, Rickards CA, Walz JM, Heard SO, Convertino VA. Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans. J Appl Physiol (1985). 2008 Feb; 104(2):475-81.
          View in: PubMed
        9. Yang Y, Soyemi O, Scott PJ, Landry MR, Lee SM, Stroud L, Soller BR. Quantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy. Opt Express. 2007 Oct 17; 15(21):13715-30.
          View in: PubMed
        10. Soller BR, Hagan RD, Shear M, Walz JM, Landry M, Anunciacion D, Orquiola A, Heard SO. Comparison of intramuscular and venous blood pH, PCO(2) and PO(2) during rhythmic handgrip exercise. Physiol Meas. 2007 Jun; 28(6):639-49.
          View in: PubMed
        11. Yang Y, Soyemi OO, Landry MR, Soller BR. Noninvasive in vivo measurement of venous blood pH during exercise using near-infrared reflectance spectroscopy. Appl Spectrosc. 2007 Feb; 61(2):223-9.
          View in: PubMed
        12. Yang Y, Shoer L, Soyemi OO, Landry MR, Soller BR. Removal of analyte-irrelevant variations in near-infrared tissue spectra. Appl Spectrosc. 2006 Sep; 60(9):1070-7.
          View in: PubMed
        13. Yang Y, Landry MR, Soyemi OO, Shear MA, Anunciacion DS, Soller BR. Simultaneous correction of the influence of skin color and fat on tissue spectroscopy by use of a two-distance fiber-optic probe and orthogonalization technique. Opt Lett. 2005 Sep 1; 30(17):2269-71.
          View in: PubMed
        14. Yang Y, Soyemi OO, Landry MR, Soller BR. Influence of a fat layer on the near infrared spectra of human muscle: quantitative analysis based on two-layered Monte Carlo simulations and phantom experiments. Opt Express. 2005 Mar 7; 13(5):1570-9.
          View in: PubMed
        15. Soyemi OO, Landry MR, Yang Y, Idwasi PO, Soller BR. Skin color correction for tissue spectroscopy: demonstration of a novel approach with tissue-mimicking phantoms. Appl Spectrosc. 2005 Feb; 59(2):237-44.
          View in: PubMed
        16. Khan T, Soller B, Naghavi M, Casscells W. Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study. Cardiology. 2005; 103(1):10-6.
          View in: PubMed
        17. Soller BR, Hsi C, Favreau J, Cingo N, Lancey RA, Okike ON, Vander Salm TJ. Multiparameter fiber optic sensor for the assessment of intramyocardial perfusion. J Card Surg. 2004 Mar-Apr; 19(2):167-74.
          View in: PubMed
        18. Soller BR, Khan T, Favreau J, Hsi C, Puyana JC, Heard SO. Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock. J Surg Res. 2003 Oct; 114(2):195-201.
          View in: PubMed
        19. Soller BR, Idwasi PO, Balaguer J, Levin S, Simsir SA, Vander Salm TJ, Collette H, Heard SO. Noninvasive, near infrared spectroscopic-measured muscle pH and PO2 indicate tissue perfusion for cardiac surgical patients undergoing cardiopulmonary bypass. Crit Care Med. 2003 Sep; 31(9):2324-31.
          View in: PubMed
        20. Soller BR, Favreau J, Idwasi PO. Investigation of electrolyte measurement in diluted whole blood using spectroscopic and chemometric methods. Appl Spectrosc. 2003 Feb; 57(2):146-51.
          View in: PubMed
        21. Hsi C, Cuenoud H, Soller BR, Kim H, Favreau J, Vander Salm TJ, Moran JM. Experimental coronary artery occlusion: relevance to off-pump cardiac surgery. Asian Cardiovasc Thorac Ann. 2002 Dec; 10(4):293-7.
          View in: PubMed
        22. Soller BR, Cabrera M, Smith SM, Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition. 2002 Oct; 18(10):930-6.
          View in: PubMed
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