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    William R Kobertz PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentBiochemistry and Molecular Pharmacology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-8861
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentChemical Biology

        Overview 
        Narrative

        Structure, Function and Modulation of Ion Channels.

        Please visit my laboratory's web page



        Bibliographic 
        selected publications
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        1. Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH. Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 2016 Jun; 42(3):351-70.
          View in: PubMed
        2. Mruk K, Kobertz WR. Bioreactive Tethers. Adv Exp Med Biol. 2015; 869:77-100.
          View in: PubMed
        3. Aromolaran AS, Subramanyam P, Chang DD, Kobertz WR, Colecraft HM. LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms. Cardiovasc Res. 2014 Dec 1; 104(3):501-11.
          View in: PubMed
        4. Malaby HL, Kobertz WR. The middle X residue influences cotranslational N-glycosylation consensus site skipping. Biochemistry. 2014 Aug 5; 53(30):4884-93.
          View in: PubMed
        5. Mruk K, Farley BM, Ritacco AW, Kobertz WR. Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 2014 Jul; 144(1):105-14.
          View in: PubMed
        6. Kobertz WR. Stoichiometry of the cardiac IKs complex. Proc Natl Acad Sci U S A. 2014 Apr 8; 111(14):5065-6.
          View in: PubMed
        7. Malaby HL, Kobertz WR. Molecular determinants of co- and post-translational N-glycosylation of type I transmembrane peptides. Biochem J. 2013 Aug 1; 453(3):427-34.
          View in: PubMed
        8. Hua Z, Kobertz WR. Chemical derivatization and purification of peptide-toxins for probing ion channel complexes. Methods Mol Biol. 2013; 995:19-30.
          View in: PubMed
        9. Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. Structural insights into neuronal K+ channel-calmodulin complexes. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13579-83.
          View in: PubMed
        10. Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3ß-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012 Sep 21; 287(39):32354-66.
          View in: PubMed
        11. O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 2011 Aug; 138(2):271-7.
          View in: PubMed
        12. Bas T, Gao GY, Lvov A, Chandrasekhar KD, Gilmore R, Kobertz WR. Post-translational N-glycosylation of type I transmembrane KCNE1 peptides: implications for membrane protein biogenesis and disease. J Biol Chem. 2011 Aug 12; 286(32):28150-9.
          View in: PubMed
        13. Chandrasekhar KD, Lvov A, Terrenoire C, Gao GY, Kass RS, Kobertz WR. O-glycosylation of the cardiac I(Ks) complex. J Physiol. 2011 Aug 1; 589(Pt 15):3721-30.
          View in: PubMed
        14. Hua Z, Lvov A, Morin TJ, Kobertz WR. Chemical control of metabolically-engineered voltage-gated K+ channels. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5021-4.
          View in: PubMed
        15. Lvov A, Gage SD, Berrios VM, Kobertz WR. Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J Gen Physiol. 2010 Jun; 135(6):607-18.
          View in: PubMed
        16. Ahern CA, Kobertz WR. Chemical tools for K(+) channel biology. Biochemistry. 2009 Jan 27; 48(3):517-26.
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        17. Mruk K, Kobertz WR. Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes. PLoS One. 2009; 4(1):e4236.
          View in: PubMed
        18. Morin TJ, Kobertz WR. Tethering chemistry and K+ channels. J Biol Chem. 2008 Sep 12; 283(37):25105-9.
          View in: PubMed
        19. Morin TJ, Kobertz WR. Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1478-82.
          View in: PubMed
        20. Rocheleau JM, Kobertz WR. KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels. J Gen Physiol. 2008 Jan; 131(1):59-68.
          View in: PubMed
        21. Morin TJ, Kobertz WR. A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes. ACS Chem Biol. 2007 Jul 20; 2(7):469-73.
          View in: PubMed
        22. Rocheleau JM, Gage SD, Kobertz WR. Secondary structure of a KCNE cytoplasmic domain. J Gen Physiol. 2006 Dec; 128(6):721-9.
          View in: PubMed
        23. Chandrasekhar KD, Bas T, Kobertz WR. KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem. 2006 Dec 29; 281(52):40015-23.
          View in: PubMed
        24. Gage SD, Kobertz WR. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol. 2004 Dec; 124(6):759-71.
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        25. Kobertz WR, Essigmann JM. An Efficient Synthesis of a Furan-Side Furocoumarin Thymidine Monoadduct. J Org Chem. 1997 Apr 18; 62(8):2630-2632.
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