X-Linked Inhibitor of Apoptosis Protein

"X-Linked Inhibitor of Apoptosis Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inhibitor of apoptosis protein that is translated by a rare cap-independent mechanism. It blocks caspase-mediated cellular destruction by inhibiting CASPASE 3; CASPASE 7; and CASPASE 9.

Descriptor ID	D051636
MeSH Number(s)	D08.811.464.938.750.210.750 D12.644.360.075.437.750 D12.776.476.075.437.750
Concept/Terms	X-Linked Inhibitor of Apoptosis Protein X-Linked Inhibitor of Apoptosis Protein X Linked Inhibitor of Apoptosis Protein XIAP Protein X-Linked IAP Protein IAP Protein, X-Linked X Linked IAP Protein

Below are MeSH descriptors whose meaning is more general than "X-Linked Inhibitor of Apoptosis Protein".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
X-Linked Inhibitor of Apoptosis Protein [D08.811.464.938.750.210.750]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
X-Linked Inhibitor of Apoptosis Protein [D12.644.360.075.437.750]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]
X-Linked Inhibitor of Apoptosis Protein [D12.776.476.075.437.750]

Below are MeSH descriptors whose meaning is related to "X-Linked Inhibitor of Apoptosis Protein".

Below are MeSH descriptors whose meaning is more specific than "X-Linked Inhibitor of Apoptosis Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in this website by year, and whether "X-Linked Inhibitor of Apoptosis Protein" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 2003 and 2004 and 2005 and 2006 and 2009 and 2012 and 2013 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	1	1
2005	1	0	1
2006	1	0	1
2009	0	1	1
2012	1	0	1
2013	1	0	1
2021	0	1	1

Below are the most recent publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in Profiles.

Hashimoto M, Saito Y, Nakagawa R, Ogahara I, Takagi S, Takata S, Amitani H, Endo M, Yuki H, Ramilowski JA, Severin J, Manabe RI, Watanabe T, Ozaki K, Kaneko A, Kajita H, Fujiki S, Sato K, Honma T, Uchida N, Fukami T, Okazaki Y, Ohara O, Shultz LD, Yamada M, Taniguchi S, Vyas P, de Hoon M, Momozawa Y, Ishikawa F. Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nat Cancer. 2021 03; 2(3):340-356.

View in: PubMed
Mahadevan D, Chalasani P, Rensvold D, Kurtin S, Pretzinger C, Jolivet J, Ramanathan RK, Von Hoff DD, Weiss GJ. Phase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma. Am J Clin Oncol. 2013 Jun; 36(3):239-43.

View in: PubMed
Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 2012; 98(5):451-65.

View in: PubMed
Yao J, Feathers KL, Khanna H, Thompson D, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1567-72.

View in: PubMed
Yu JG, Sewright K, Hubal MJ, Liu JX, Schwartz LM, Hoffman EP, Clarkson PM. Investigation of gene expression in C(2)C(12) myotubes following simvastatin application and mechanical strain. J Atheroscler Thromb. 2009 Mar; 16(1):21-9.

View in: PubMed
LaCasse EC, Cherton-Horvat GG, Hewitt KE, Jerome LJ, Morris SJ, Kandimalla ER, Yu D, Wang H, Wang W, Zhang R, Agrawal S, Gillard JW, Durkin JP. Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis. Clin Cancer Res. 2006 Sep 01; 12(17):5231-41.

View in: PubMed
Lacasse EC, Kandimalla ER, Winocour P, Sullivan T, Agrawal S, Gillard JW, Durkin J. Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640. Ann N Y Acad Sci. 2005 Nov; 1058:215-34.

View in: PubMed
McManus DC, Lefebvre CA, Cherton-Horvat G, St-Jean M, Kandimalla ER, Agrawal S, Morris SJ, Durkin JP, Lacasse EC. Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. Oncogene. 2004 Oct 21; 23(49):8105-17.

View in: PubMed
Ramp U, Caliskan E, Mahotka C, Krieg A, Heikaus S, Gabbert HE, Gerharz CD. Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer. 2003 Jun 02; 88(11):1800-7.

View in: PubMed

People

Explore

Similar Concepts

Top Journals