Retinal Pigment Epithelium

"Retinal Pigment Epithelium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.

Descriptor ID	D055213
MeSH Number(s)	A09.371.670.500 A09.371.729.887
Concept/Terms	Retinal Pigment Epithelium Retinal Pigment Epithelium Pigment Epithelium, Retinal Epithelium, Retinal Pigment

Below are MeSH descriptors whose meaning is more general than "Retinal Pigment Epithelium".

Anatomy [A]
Sense Organs [A09]
Eye [A09.371]
Pigment Epithelium of Eye [A09.371.670]
Retinal Pigment Epithelium [A09.371.670.500]
Retina [A09.371.729]
Retinal Pigment Epithelium [A09.371.729.887]

Below are MeSH descriptors whose meaning is related to "Retinal Pigment Epithelium".

Below are MeSH descriptors whose meaning is more specific than "Retinal Pigment Epithelium".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinal Pigment Epithelium" by people in this website by year, and whether "Retinal Pigment Epithelium" was a major or minor topic of these publications.

Bar chart showing 28 publications over 13 distinct years, with a maximum of 4 publications in 2014 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	2	0	2
2009	1	0	1
2011	1	0	1
2013	2	0	2
2014	2	2	4
2015	2	1	3
2016	3	1	4
2017	2	1	3
2019	2	1	3
2020	0	1	1
2023	0	1	1
2024	0	1	1
2025	1	1	2

Below are the most recent publications written about "Retinal Pigment Epithelium" by people in Profiles.

Cheng SY, Giguere D, Silverstein I, Conza A, Seddon JM, Kim S, Iwata T, Mueller C, Punzo C. Role of alpha-1 antitrypsin in Bruch's membrane integrity. Sci Rep. 2025 Apr 10; 15(1):12223.

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Choi H, Corradetti G, Lindenberg S, Karamat AN, Oncel D, Liu H, Gnanaraj R, Fasih-Ahmad S, Marion KM, Baker KL, Gulati S, Foster B, Lam A, Sadda SR, Lally DR. Incomplete RPE and Outer Retinal Atrophy (iRORA) Development in Eyes With Fellow-eye Neovascular Age-related Macular Degeneration. Ophthalmic Surg Lasers Imaging Retina. 2025 May; 56(5):274-279.

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Kumari A, Caliz AD, Yoo HJ, Kant S, Vertii A. TNF-alpha promotes cilia elongation via mixed lineage kinases signaling in mouse fibroblasts and human RPE-1 cells. Cytoskeleton (Hoboken). 2024 Nov; 81(11):639-647.

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Akkan Aydogmus FS, Onwuka O, Saddemi J, Lasalle CC, Ramsey DJ. Second eyes to develop neovascular age-related macular degeneration have fewer symptoms and better one-year visual outcomes. BMC Ophthalmol. 2023 Jul 07; 23(1):303.

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Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C. Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Proc Natl Acad Sci U S A. 2020 06 09; 117(23):13094-13104.

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Muhammad F, Trivett A, Wang D, Lee DJ. Tissue-specific production of MicroRNA-155 inhibits melanocortin 5 receptor-dependent suppressor macrophages to promote experimental autoimmune uveitis. Eur J Immunol. 2019 11; 49(11):2074-2082.

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Wang LW, Nandadasa S, Annis DS, Dubail J, Mosher DF, Willard BB, Apte SS. A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover. J Biol Chem. 2019 06 21; 294(25):9924-9936.

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Wang L, Schmidt S, Larsen PP, Meyer JH, Roush WR, Latz E, Holz FG, Krohne TU. Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells. J Mol Med (Berl). 2019 04; 97(4):523-532.

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Chekuri A, Sahu B, Chavali VRM, Voronchikhina M, Soto-Hermida A, Suk JJ, Alapati AN, Bartsch DU, Ayala-Ramirez R, Zenteno JC, Dinculescu A, Jablonski MM, Borooah S, Ayyagari R. Long-Term Effects of Gene Therapy in a Novel Mouse Model of Human MFRP-Associated Retinopathy. Hum Gene Ther. 2019 05; 30(5):632-650.

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Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 01; 24(1):50-61.

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