Interleukin-21 Receptor alpha Subunit
"Interleukin-21 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interleukin-21 receptor subunit that combines with the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT to form a high affinity receptor for interleukin-21. It signals via interaction of its cytoplasmic domain with JANUS KINASES such as JANUS KINASE 1 and JANUS KINASE 3.
| Descriptor ID |
D053738
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| MeSH Number(s) |
D12.776.543.750.705.852.420.900.450
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| Concept/Terms |
Interleukin-21 Receptor alpha Subunit- Interleukin-21 Receptor alpha Subunit
- Interleukin 21 Receptor alpha Subunit
- IL-21 Receptor alpha Chain
- IL 21 Receptor alpha Chain
- Interleukin-21 Receptor alpha Chain
- Interleukin 21 Receptor alpha Chain
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Below are MeSH descriptors whose meaning is more general than "Interleukin-21 Receptor alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-21 Receptor alpha Subunit".
This graph shows the total number of publications written about "Interleukin-21 Receptor alpha Subunit" by people in this website by year, and whether "Interleukin-21 Receptor alpha Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-21 Receptor alpha Subunit" by people in Profiles.
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Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015 Dec 01; 195(11):5251-60.
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Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006 Jul; 116(7):2044-55.
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Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol. 2003 Jul 15; 171(2):608-15.
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Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002 Apr; 16(4):559-69.