Pregnanolone

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"Pregnanolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.

Descriptor ID	D011280
MeSH Number(s)	D04.210.500.745.640
Concept/Terms	Pregnanolone Pregnanolone 3 alpha-Hydroxy-5 beta-pregnan-20-one 3 alpha Hydroxy 5 beta pregnan 20 one alpha-Hydroxy-5 beta-pregnan-20-one, 3 beta-pregnan-20-one, 3 alpha-Hydroxy-5 3-Hydroxypregnan-20-one 3 Hydroxypregnan 20 one Pregnanolone, (3alpha,5beta)-isomer Eltanolone Pregnan-3alpha-ol-20-one Pregnan 3alpha ol 20 one 3 alpha, 5 beta-Tetrahydroprogesterone 3 alpha, 5 beta Tetrahydroprogesterone Pregnanolone, (3alpha)-isomer Pregnanolone, (3alpha)-isomer Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer Sepranolone Sepranolone Allopregnanolone 3 alpha-Hydroxy-5 alpha-pregnan-20-one 3 alpha Hydroxy 5 alpha pregnan 20 one alpha-Hydroxy-5 alpha-pregnan-20-one, 3 alpha-pregnan-20-one, 3 alpha-Hydroxy-5 Pregnanolone, (3alpha,5alpha)-isomer Pregnanolone, (3beta, 5beta,14beta)-isomer Pregnanolone, (3beta, 5beta,14beta)-isomer Pregnanolone, (3beta, 5alpha)-isomer Pregnanolone, (3beta, 5alpha)-isomer Allopregnan-3 beta-ol-20-one Allopregnan 3 beta ol 20 one beta-ol-20-one, Allopregnan-3 3beta-Hydroxy-5alpha-pregnan-20-one 3beta Hydroxy 5alpha pregnan 20 one Pregnanolone, (3beta, 5alpha, 17alpha)-isomer Pregnanolone, (3beta, 5alpha, 17alpha)-isomer Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer Pregnanolone, (3beta, 5beta)-isomer Pregnanolone, (3beta, 5beta)-isomer Epipregnanolone Pregnanolone, (3beta, 5beta, 17alpha)-isomer Pregnanolone, (3beta, 5beta, 17alpha)-isomer Pregnanolone, (5alpha)-isomer Pregnanolone, (5alpha)-isomer Pregnanolone, (3beta)-isomer Pregnanolone, (3beta)-isomer

Below are MeSH descriptors whose meaning is more general than "Pregnanolone".

Chemicals and Drugs [D]
Polycyclic Compounds [D04]
Fused-Ring Compounds [D04.210]
Steroids [D04.210.500]
Pregnanes [D04.210.500.745]
Pregnanolone [D04.210.500.745.640]

Below are MeSH descriptors whose meaning is related to "Pregnanolone".

Below are MeSH descriptors whose meaning is more specific than "Pregnanolone".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pregnanolone" by people in this website by year, and whether "Pregnanolone" was a major or minor topic of these publications.

Bar chart showing 12 publications over 7 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2013	1	0	1
2016	0	1	1
2017	1	0	1
2018	1	1	2
2019	2	0	2
2020	2	1	3
2022	2	0	2

Below are the most recent publications written about "Pregnanolone" by people in Profiles.

Miller SL, Bennet L, Sutherland AE, Pham Y, McDonald C, Castillo-Melendez M, Allison BJ, Mihelakis J, Nitsos I, Boyd BJ, Hirst JJ, Walker DW, Hunt RW, Jenkin G, Wong F, Malhotra A, Fahey MC, Yawno T. Ganaxolone versus Phenobarbital for Neonatal Seizure Management. Ann Neurol. 2022 Dec; 92(6):1066-1079.

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Wald J, Henningsson A, Hanze E, Hoffmann E, Li H, Colquhoun H, Deligiannidis KM. Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose. Clin Pharmacokinet. 2022 09; 61(9):1307-1319.

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Deligiannidis KM, Kroll-Desrosiers AR, Tan Y, Dubuke ML, Shaffer SA. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121:104827.

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Carlini SV, Deligiannidis KM. Evidence-Based Treatment of Premenstrual Dysphoric Disorder: A Concise Review. J Clin Psychiatry. 2020 02 04; 81(2).

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Jarman AF, MacLean JV, Barron RJ, Wightman RS, McGregor AJ. Brexanolone For Postpartum Depression: A Novel Approach and a Call for Comprehensive Postpartum Care. Clin Ther. 2020 01; 42(1):231-235.

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Fantasia HC. Brexanolone Is the First Drug Specifically for Postpartum Depression. Nurs Womens Health. 2019 Oct; 23(5):450-454.

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Frieder A, Fersh M, Hainline R, Deligiannidis KM. Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development. CNS Drugs. 2019 03; 33(3):265-282.

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Deligiannidis KM, Fales CL, Kroll-Desrosiers AR, Shaffer SA, Villamarin V, Tan Y, Hall JE, Frederick BB, Sikoglu EM, Edden RA, Rothschild AJ, Moore CM. Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance?imaging and spectroscopy?study. Neuropsychopharmacology. 2019 02; 44(3):546-554.

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Meltzer-Brody S, Colquhoun H, Riesenberg R, Epperson CN, Deligiannidis KM, Rubinow DR, Li H, Sankoh AJ, Clemson C, Schacterle A, Jonas J, Kanes S. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet. 2018 09 22; 392(10152):1058-1070.

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Kanes S, Colquhoun H, Gunduz-Bruce H, Raines S, Arnold R, Schacterle A, Doherty J, Epperson CN, Deligiannidis KM, Riesenberg R, Hoffmann E, Rubinow D, Jonas J, Paul S, Meltzer-Brody S. Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial. Lancet. 2017 07 29; 390(10093):480-489.

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