"Pregnanolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
| Descriptor ID |
D011280
|
| MeSH Number(s) |
D04.210.500.745.640
|
| Concept/Terms |
Pregnanolone- Pregnanolone
- 3 alpha-Hydroxy-5 beta-pregnan-20-one
- 3 alpha Hydroxy 5 beta pregnan 20 one
- alpha-Hydroxy-5 beta-pregnan-20-one, 3
- beta-pregnan-20-one, 3 alpha-Hydroxy-5
- 3-Hydroxypregnan-20-one
- 3 Hydroxypregnan 20 one
- Pregnanolone, (3alpha,5beta)-isomer
- Eltanolone
- Pregnan-3alpha-ol-20-one
- Pregnan 3alpha ol 20 one
- 3 alpha, 5 beta-Tetrahydroprogesterone
- 3 alpha, 5 beta Tetrahydroprogesterone
Sepranolone- Sepranolone
- Allopregnanolone
- 3 alpha-Hydroxy-5 alpha-pregnan-20-one
- 3 alpha Hydroxy 5 alpha pregnan 20 one
- alpha-Hydroxy-5 alpha-pregnan-20-one, 3
- alpha-pregnan-20-one, 3 alpha-Hydroxy-5
- Pregnanolone, (3alpha,5alpha)-isomer
Pregnanolone, (3beta, 5alpha)-isomer- Pregnanolone, (3beta, 5alpha)-isomer
- Allopregnan-3 beta-ol-20-one
- Allopregnan 3 beta ol 20 one
- beta-ol-20-one, Allopregnan-3
- 3beta-Hydroxy-5alpha-pregnan-20-one
- 3beta Hydroxy 5alpha pregnan 20 one
|
Below are MeSH descriptors whose meaning is more general than "Pregnanolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnanolone".
This graph shows the total number of publications written about "Pregnanolone" by people in this website by year, and whether "Pregnanolone" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 1 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 2 | 3 | 5 |
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click here.
Below are the most recent publications written about "Pregnanolone" by people in Profiles.
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Schoretsanitis G, Osborne LM, Sundstr?m-Poromaa I, Wenzel ES, Payne JL, Barbui C, Gastaldon C, Deligiannidis KM. Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis. Mol Psychiatry. 2025 Mar; 30(3):1148-1160.
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Deligiannidis KM, Bullock A, Nandy I, Dunbar J, Lasser R, Witte M, Leclair B, Wald J. Zuranolone Concentrations in the Breast Milk of Healthy, Lactating Individuals: Results From a Phase 1 Open-Label Study. J Clin Psychopharmacol. 2024 Jul-Aug 01; 44(4):337-344.
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Meltzer-Brody S, Gerbasi ME, Mak C, Toubouti Y, Smith S, Roskell N, Tan R, Chen SS, Deligiannidis KM. Indirect comparisons of relative efficacy estimates of zuranolone and selective serotonin reuptake inhibitors for postpartum depression. J Med Econ. 2024 Jan-Dec; 27(1):582-595.
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O'Callaghan L, Chertavian E, Johnson SJ, Ferries E, Deligiannidis KM. The cost-effectiveness of zuranolone versus selective serotonin reuptake inhibitors for the treatment of postpartum depression in the United States. J Med Econ. 2024 Jan-Dec; 27(1):492-505.
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Clayton AH, Suthoff E, Jain R, Kosinski M, Fridman M, Deligiannidis KM, Meltzer-Brody S, Chen SY, Gervitz L, Huang MY, Trivedi M, Bonthapally V. The magnitude and sustainability of treatment benefit of zuranolone on function and well-being as assessed by the SF-36 in adult patients with MDD and PPD: An integrated analysis of 4 randomized clinical trials. J Affect Disord. 2024 Apr 15; 351:904-914.
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Carlini SV, Osborne LM, Deligiannidis KM. Current pharmacotherapy approaches and novel GABAergic antidepressant development in postpartum depression. Dialogues Clin Neurosci. 2023 12; 25(1):92-100.
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Wald J, Henningsson A, Hanze E, Hoffmann E, Li H, Colquhoun H, Deligiannidis KM. Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose. Clin Pharmacokinet. 2022 09; 61(9):1307-1319.
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Deligiannidis KM, Kroll-Desrosiers AR, Tan Y, Dubuke ML, Shaffer SA. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121:104827.
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Carlini SV, Deligiannidis KM. Evidence-Based Treatment of Premenstrual Dysphoric Disorder: A Concise Review. J Clin Psychiatry. 2020 02 04; 81(2).
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Jarman AF, MacLean JV, Barron RJ, Wightman RS, McGregor AJ. Brexanolone For Postpartum Depression: A Novel Approach and a Call for Comprehensive Postpartum Care. Clin Ther. 2020 01; 42(1):231-235.