"Gene Products, rev" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.
| Descriptor ID |
D015694
|
| MeSH Number(s) |
D12.776.157.725.076 D12.776.664.962.186 D12.776.964.925.984.385
|
| Concept/Terms |
Gene Products, rev- Gene Products, rev
- rev Gene Products
- rev Protein
- Gene Product, rev
- rev Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, rev".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, rev".
This graph shows the total number of publications written about "Gene Products, rev" by people in this website by year, and whether "Gene Products, rev" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, rev" by people in Profiles.
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Yu Z, S?nchez-Velar N, Catrina IE, Kittler EL, Udofia EB, Zapp ML. The cellular HIV-1 Rev cofactor hRIP is required for viral replication. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):4027-32.
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S?nchez-Velar N, Udofia EB, Yu Z, Zapp ML. hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. Genes Dev. 2004 Jan 01; 18(1):23-34.
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Alexander L, Denekamp L, Czajak S, Desrosiers RC. Suboptimal nucleotides in the infectious, pathogenic simian immunodeficiency virus clone SIVmac239. J Virol. 2001 Apr; 75(8):4019-22.
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Hwang S, Tamilarasu N, Rana TM. Selection of HIV replication inhibitors: chemistry and biology. Adv Pharmacol. 2000; 49:167-97.
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Ping YH, Liu Y, Wang X, Neenhold HR, Rana TM. Dynamics of RNA-protein interactions in the HIV-1 Rev-RRE complex visualized by 6-thioguanosine-mediated photocrosslinking. RNA. 1997 Aug; 3(8):850-60.
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Zhang G, Zapp ML, Yan G, Green MR. Localization of HIV-1 RNA in mammalian nuclei. J Cell Biol. 1996 Oct; 135(1):9-18.
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Fritz CC, Green MR. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr Biol. 1996 Jul 01; 6(7):848-54.
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Werstuck G, Zapp ML, Green MR. A non-canonical base pair within the human immunodeficiency virus rev-responsive element is involved in both rev and small molecule recognition. Chem Biol. 1996 Feb; 3(2):129-37.
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Fritz CC, Zapp ML, Green MR. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature. 1995 Aug 10; 376(6540):530-3.