 Drug Design
"Drug Design" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
| Descriptor ID |
D015195
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| MeSH Number(s) |
E05.295.500 H01.158.703.007.675.500 H01.181.466.675.500
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| Concept/Terms |
Drug Design- Drug Design
- Design, Drug
- Designs, Drug
- Drug Designs
Drug Modeling- Drug Modeling
- Drug Modelings
- Modeling, Drug
- Modelings, Drug
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Below are MeSH descriptors whose meaning is more general than "Drug Design".
Below are MeSH descriptors whose meaning is more specific than "Drug Design".
This graph shows the total number of publications written about "Drug Design" by people in this website by year, and whether "Drug Design" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 5 | 7 | | 2007 | 5 | 7 | 12 | | 2008 | 0 | 6 | 6 | | 2009 | 2 | 5 | 7 | | 2010 | 2 | 4 | 6 | | 2011 | 2 | 4 | 6 | | 2012 | 1 | 2 | 3 | | 2013 | 3 | 4 | 7 | | 2014 | 0 | 3 | 3 | | 2015 | 2 | 2 | 4 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Design" by people in Profiles.
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Pierce BG, Boucher EN, Piepenbrink KH, Ejemel M, Rapp CA, Thomas WD, Sundberg EJ, Weng Z, Wang Y. Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope. J Virol. 2017 10 15; 91(20).
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Shishkina AV, Makarova TM, Tereshchenkov AG, Makarov GI, Korshunova GA, Bogdanov AA. Modeling Interactions of Erythromycin Derivatives with Ribosomes. Biochemistry (Mosc). 2015 Nov; 80(11):1500-7.
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Nyberg F, Askling J, Berglind N, Franzén S, Ho M, Holmqvist M, Horne L, Lampl K, Michaud K, Pappas DA, Reed G, Symmons D, Tanaka E, Tran TN, Verstappen SM, Wesby-van Swaay E, Yamanaka H, Greenberg JD. Using epidemiological registry data to provide background rates as context for adverse events in a rheumatoid arthritis drug development program: a coordinated approach. Pharmacoepidemiol Drug Saf. 2015 Nov; 24(11):1121-32.
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Feely MA, Smith BL, Weinberg JM. Novel psoriasis therapies and patient outcomes, Part 3: Systemic medications. Cutis. 2015 Jul; 96(1):47-53.
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Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015 Feb 12; 58(3):1337-44.
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Korin N, Gounis MJ, Wakhloo AK, Ingber DE. Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics. JAMA Neurol. 2015 Jan; 72(1):119-22.
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Maan A, Mansour M, McManus DD, Patel VV, Cheng A, Ruskin JN, Heist EK. Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec; 14(6):403-21.
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Blair LM, Colby Davie EA, Sperry J. Total synthesis of putative montamine and a proposed structural reassignment. Org Biomol Chem. 2014 Sep 21; 12(35):6878-84.
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Hara T, Urano F. [ER stress and ß cell death - therapeutic approach to combat ER stress]. Nihon Yakurigaku Zasshi. 2014 Aug; 144(2):53-8.
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Hilbert BJ, Grossman SR, Schiffer CA, Royer WE. Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. FEBS Lett. 2014 May 2; 588(9):1743-8.
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