Disease Progression

"Disease Progression" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Descriptor ID	D018450
MeSH Number(s)	C23.550.291.656
Concept/Terms	Disease Progression Disease Progression Disease Progressions Progression, Disease Progressions, Disease Disease Exacerbation Disease Exacerbation

Below are MeSH descriptors whose meaning is more general than "Disease Progression".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Disease Attributes [C23.550.291]
Disease Progression [C23.550.291.656]

Below are MeSH descriptors whose meaning is related to "Disease Progression".

Below are MeSH descriptors whose meaning is more specific than "Disease Progression".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Disease Progression" by people in this website by year, and whether "Disease Progression" was a major or minor topic of these publications.

Bar chart showing 805 publications over 31 distinct years, with a maximum of 55 publications in 2015 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	6	6
1997	0	2	2
1998	0	5	5
1999	0	5	5
2000	0	8	8
2001	0	9	9
2002	0	9	9
2003	0	17	17
2004	0	11	11
2005	0	26	26
2006	0	24	24
2007	1	24	25
2008	0	28	28
2009	1	20	21
2010	2	30	32
2011	2	40	42
2012	3	32	35
2013	3	35	38
2014	4	47	51
2015	7	48	55
2016	6	40	46
2017	7	40	47
2018	10	45	55
2019	6	34	40
2020	7	44	51
2021	4	27	31
2022	1	24	25
2023	0	21	21
2024	11	19	30
2025	1	8	9

Below are the most recent publications written about "Disease Progression" by people in Profiles.

Sciurba FC, Criner GJ, Christenson SA, Martinez FJ, Papi A, Roche N, Bourbeau J, Korn S, Bafadhel M, Han MK, Kolterer S, Miller K, Mouneimne D, Fletcher J, Mayer B, Min J, Pavord ID. Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype. N Engl J Med. 2025 May 01; 392(17):1710-1720.

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Dunlay SM, Pinney SP, Lala A, Stewart GC, McIlvennan C, Wong RP, Morris AA, Pagani FD, Allen LA, Breathett K, Cogswell R, Colvin MM, Cowger JA, Drakos SG, Gelfman LP, Kanwar MK, Kiernan MS, Kittleson MM, Lewis EF, Moazami N, Ogunniyi MO, Pandey A, Rogers JG, Schumacher KR, Slaughter MS, Tedford RJ, Teuteberg J, Valantine HA, DeFilippis EM, Dixon DD, Golbus JR, Gulati G, Hanff TC, Hsiao S, Lewsey SC, McCormick AD, Nayak A, Fenton KN, Longacre LS, Shanbhag SM, Taddei-Peters WC, Stevenson LW. Recognition of the Large Ambulatory C2D Stage of Advanced Heart Failure-A Call to Action. JAMA Cardiol. 2025 Apr 01; 10(4):391-398.

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Bell AJ, Ram S, Labaki WW, Murray S, Kazerooni EA, Galban S, Martinez FJ, Hatt CR, Wang JM, Ivanov V, McGettigan P, Khokhlovich E, Maiorino E, Suryadevara R, Boueiz A, Castaldi PJ, Mirkes EM, Zinovyev A, Gorban AN, Galban CJ, Han MK. Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts. Am J Respir Crit Care Med. 2025 Apr; 211(4):569-576.

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McManus RM, Komes MP, Griep A, Santarelli F, Schwartz S, Ram?n Perea J, Schlachetzki JCM, Bouvier DS, Khalil MA, Lauterbach MA, Heinemann L, Schl?ter T, Pour MS, Lovotti M, Stahl R, Duthie F, Rodr?guez-Alc?zar JF, Schmidt SV, Spitzer J, Noori P, Maillo A, Boettcher A, Herron B, McConville J, Gomez-Cabrero D, Tegn?r J, Glass CK, Hiller K, Latz E, Heneka MT. NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression. Immunity. 2025 Feb 11; 58(2):326-343.e11.

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Burnim M, Putcha N, LaFon D, Woo H, Azar A, Groenke L, Stampfli M, Schaub A, Fawzy A, Balasubramanian A, Fedarko N, Cooper CB, Bowler RP, Comellas A, Krishnan JA, Han MK, Couper D, Peters SP, Drummond MB, O'Neal W, Paine R, Criner G, Martinez FJ, Curtis JL, Barr G, Huang YJ, Woodruff P, Dransfield M, Hansel NN. Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS. Am J Respir Crit Care Med. 2025 Feb; 211(2):215-221.

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Schneider LS, Freiesleben SD, van Breukelen G, Wang X, Brosseron F, Heneka MT, Teipel S, Kleineidam L, Stark M, Roy-Kluth N, Wagner M, Spottke A, Schmid M, Roeske S, Laske C, Munk MH, Perneczky R, Rauchmann BS, Buerger K, Janowitz D, D?zel E, Glanz W, Jessen F, Rostamzadeh A, Wiltfang J, Bartels C, Kilimann I, Schneider A, Fliessbach K, Priller J, Spruth EJ, Hellmann-Regen J, Peters O. Linking higher amyloid beta 1-38 (A?(1-38)) levels to reduced Alzheimer's disease progression risk. Alzheimers Dement. 2025 Feb; 21(2):e14545.

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Kolstad J, Zoppo C, Johnston JM, D'Souza P, K?hn AL, Vardar Z, Peker A, Hader A, Celik H, Lewis CJ, Lindsay C, Rentiya ZS, Lebel C, Vedantham S, Vachha B, Gray-Edwards HL, Acosta MT, Tifft CJ, Shazeeb MS. Natural history progression of MRI brain volumetrics in type II late-infantile and juvenile GM1 gangliosidosis patients. Mol Genet Metab. 2025 Mar; 144(3):109025.

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Dogan EO, Simonini SR, Bouley J, Weiss A, Brown RH, Henninger N. Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis. Ann Neurol. 2025 May; 97(5):963-975.

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Fukui S, Winkelmayer WC, Tedeschi SK, Marrugo J, Guan H, Harrold L, Litman HJ, Shinozaki T, Solomon DH. Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study. Ann Rheum Dis. 2025 Feb; 84(2):201-209.

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Fortis S, Guo J, Nagpal P, Chaudhary MFA, Newell JD, Gerard SE, Han MK, Kazerooni EA, Martinez FJ, Barjaktarevic IZ, Barr RG, Bodduluri S, Paine R, Awan HA, Schroeder JD, Gravens-Mueller LD, Ortega VE, Anderson WH, Cooper CB, Couper D, Woodruff PG, Bowler RP, Bhatt SP, Hoffman EA, Reinhardt JM, Comellas AP. Association of Ground-Glass Opacities with Systemic Inflammation and Progression of Emphysema. Am J Respir Crit Care Med. 2024 Dec 15; 210(12):1432-1440.

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