Disease Progression

"Disease Progression" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Descriptor ID	D018450
MeSH Number(s)	C23.550.291.656
Concept/Terms	Disease Progression Disease Progression Disease Progressions Progression, Disease Progressions, Disease Disease Exacerbation Disease Exacerbation

Below are MeSH descriptors whose meaning is more general than "Disease Progression".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Disease Attributes [C23.550.291]
Disease Progression [C23.550.291.656]

Below are MeSH descriptors whose meaning is related to "Disease Progression".

Below are MeSH descriptors whose meaning is more specific than "Disease Progression".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Disease Progression" by people in this website by year, and whether "Disease Progression" was a major or minor topic of these publications.

Bar chart showing 921 publications over 31 distinct years, with a maximum of 62 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	6	6
1997	0	2	2
1998	0	5	5
1999	0	5	5
2000	0	7	7
2001	0	10	10
2002	0	9	9
2003	0	17	17
2004	0	11	11
2005	0	28	28
2006	0	24	24
2007	1	27	28
2008	0	28	28
2009	1	24	25
2010	3	34	37
2011	3	40	43
2012	3	36	39
2013	4	40	44
2014	5	52	57
2015	7	48	55
2016	6	43	49
2017	7	47	54
2018	10	51	61
2019	7	42	49
2020	8	54	62
2021	4	33	37
2022	2	27	29
2023	0	28	28
2024	15	26	41
2025	2	28	30
2026	0	1	1

Below are the most recent publications written about "Disease Progression" by people in Profiles.

Zhou L, DeMarco KD, Murphy KC, Wu Z, Li J, Johnson C, Liu B, Giwa HK, Ma B, Bhalerao N, Li J, Jiang Z, Bai S, Parikh CN, Ye T, Simin K, Zhu LJ, Pitarresi JR, Wu H, Ruscetti M. p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression and Progression That Can Be Reversed by Senolytic Therapy. Cancer Discov. 2026 Mar 02; 16(3):571-591.

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Shin JH, Kim JY, Kim SH, Kang Y, Lee HJ, Kim MJ, Choi J, Jeong SK, Park SO, Cho YB, Kim KK, Shim JH, Chun E, Lee KY. USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis. Cell Death Dis. 2025 Dec 19; 16(1):894.

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Seneschal J, Bae JM, Ezzedine K, Hamzavi I, Harris JE, Bellei B, Parsad D, Passeron T, van Geel N, Boniface K, Picardo M. Vitiligo. Nat Rev Dis Primers. 2025 Dec 04; 11(1):85.

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Hoesterey DT, Dang H, Markovic D, Buhr RG, Tashkin DP, Barr RG, Belperio JA, Bowler RP, Bleecker ER, Couper DJ, Criner GJ, Cooper CB, Doerschuk CM, Dransfield MT, Drummond MB, Fawzy A, Freeman CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Huang YJ, Kaner RJ, Kanner RE, Kim V, Krishnan JA, Martinez FJ, O'Neal WK, Ortega VE, Paine R, Shrivastav AK, Wells JM, Woodruff PG, Curtis JL, Barjaktarevic I. Neutrophil-to-Lymphocyte Ratio as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS Cohort. Ann Am Thorac Soc. 2025 Dec; 22(12):1881-1890.

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Shin JH, Kim JY, Kim MJ, Kang Y, Lee HJ, Choi B, Lee JS, Kwon D, Kim SH, Sung Y, Kim DH, Shim JH, Chun E, Lee KY. PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathways. Exp Mol Med. 2025 Nov; 57(11):2559-2573.

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Ressa G, Levi R, Savini G, Raspagliesi L, Clerici E, Bellu L, Cappellini LA, Grimaldi M, Pancetti S, Bono B, Franzini A, Riva M, Fernandez B, Niyazi M, Pessina F, Minniti G, Navarria P, Scorsetti M, Politi LS. AI differentiates radionecrosis from true progression in brain metastasis upon stereotactic radiosurgery: Analysis of 124 histologically assessed lesions. Neuro Oncol. 2025 Nov 01; 27(11):3029-3039.

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Elias LM, Agins JE, Goldberg DS, Bittermann T, Byhoff E. The impact of food insecurity on chronic liver disease: A systematic review of the literature. Hepatol Commun. 2025 Nov 01; 9(11).

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Paudel ML, Shadick N, Weinblatt M, Reed G, Litman HJ, Kremer JM, Pappas DA, Solomon DH. Development and External Validation of a Multivariable Predictive Model for Progression to Difficult-to-Treat Rheumatoid Arthritis in Biologic-Experienced Patients. Arthritis Care Res (Hoboken). 2026 Jan; 78(1):54-65.

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Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice. Aging Cell. 2025 Nov; 24(11):e70148.

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Rosenberg M, Perez Coulter A, Pepper V, Banever G, Tashjian D, Moriarty K, Tirabassi MV. Pediatric rare earth magnet ingestion: Defining "progression" in serial abdominal imaging. J Pediatr Surg. 2026 Jan; 61(1):162527.

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