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Raffi Van Aroian PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 219
Worcester MA 01605
Phone508-856-8169
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MA, United StatesBSPhysics
    California Institute of Technology, Pasadena, CA, United StatesPHDBiology
    Collapse awards and honors
    2000 - 2003Young Investigator Award, Beckman Foundation
    2000 - 2003New Investigator Award in Toxicology, Burroughs Wellcome Fund
    1998 - 1999Hellman Faculty Award , Hellman Foundation

    Collapse Overview 
    Collapse overview


    The Aroian Group studies human/animal parasitic nematodes as well as bacterial toxins.



    Our main goal is to discover new and superior treatments for human soil-transmitted helminths (intestinal nematode parasites).  These parasites, aka hookworm, whipworm, and Ascaris (large roundworm) infect upwards of 2 billion people in the world and are leading causes of childhood stunting (physical/cognitive), malutrition, adverse preganancy outcomes, loss of productivity... worldwide.  For example, when once prevalent in the United States, it is estimated that hookworm-infected US children made 40% less money when they grew up than uninfected peers. These parasites are major causes of poverty worldwide.  In addition, the drugs we have now to treat these infections are inadequate to treat some of the parasites and inadequate to eradicate all of them.  We are discovering and developing new de-worming (anthelmintic) compounds with superior characteristics to those currently in use and developing novel delivery strategies to make these compounds available widely and cheaply in the developing world. We are also studying how anthelmintic compounds work and how parasite resistance can be overcome.



    We are also studying how these parasites interact with their host.  In particular, we are interested in studying how these parasites modulate the host and host immune system in a way that might control autoimmune diseases.



    Another group in the laboratory uses the free-living nematode Caenorhabditis elegans to study how bacterial pore-forming toxins work and how the innate immune system protects against bacterial toxin attack.  Since pore-forming toxins are by far the most common mechanism pathogenic bacteria use to attack us, these studies have important implications in the control of bacterial pathogens and diseases, such as those caused by Staphyloccocus and Streptococcus.


    Collapse Rotation Projects


    The Aroian Group is actively recruiting graduate students to:



    1. use microbiology and genetics to develop new methods for delivery of protein therapies (anthelmintics) to the GI tract



    2. discovery and mechanism of action studies of new anthelmintics to control soil-transmitted helminths



    3. study how vertebrate hosts and their immune system interact with intestinal nematodes, with the particular goal of controlling autoimmune disease



    4. study innate immune mechanisms that protect animals against pore-forming toxin attack



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Williams PDE, Brewer MT, Aroian RV, Robertson AP, Martin RJ. The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole. PLoS Pathog. 2024 May; 20(5):e1011835. PMID: 38758969.
      Citations:    
    2. Hsieh HC, Huang IH, Chang SW, Chen PL, Su YC, Wang S, Tsai WJ, Chen PH, Aroian RV, Chen CS. PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins. Autophagy. 2024 Jun; 20(6):1335-1358. PMID: 38261662.
      Citations:    Fields:    
    3. Williams PDE, Brewer MT, Aroian R, Robertson AP, Martin RJ. The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole. bioRxiv. 2023 Nov 20. PMID: 38045368.
      Citations:    
    4. Aroian RV, Loukas A, Martin RJ. Anthelmintics V: Drugs, resistance, and vaccines. Int J Parasitol. 2023 07; 53(8):391-392. PMID: 37257805.
      Citations:    Fields:    
    5. Li H, Gazzola D, Hu Y, Aroian RV. An efficient method for viable cryopreservation and recovery of hookworms and other gastrointestinal nematodes in the laboratory. Int J Parasitol. 2023 07; 53(8):451-458. PMID: 37201563.
      Citations:    Fields:    Translation:HumansAnimals
    6. Shaver AO, Wit J, Dilks CM, Crombie TA, Li H, Aroian RV, Andersen EC. Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains. PLoS Pathog. 2023 04; 19(4):e1011285. PMID: 37011090.
      Citations: 4     Fields:    Translation:HumansAnimals
    7. Li H, Gazzola D, Hu Y, Aroian RV. An efficient method for viable cryopreservation of hookworms and other gastrointestinal nematodes in the laboratory. bioRxiv. 2023 Feb 01. PMID: 36778351.
      Citations:    
    8. Sitaram A, Yin Y, Zamaitis T, Zhang B, Aroian RV. A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins. PLoS Pathog. 2022 11; 18(11):e1010656. PMID: 36374839.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Chicca J, Cazeault NR, Rus F, Abraham A, Garceau C, Li H, Atwa SM, Flanagan K, Soto ER, Morrison MS, Gazzola D, Hu Y, Liu DR, Nielsen MK, Urban JF, Ostroff GR, Aroian RV. Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis. Microbiol Spectr. 2022 08 31; 10(4):e0235622. PMID: 35946940.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Ju S, Chen H, Wang S, Lin J, Ma Y, Aroian RV, Peng D, Sun M. C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens. Commun Biol. 2022 06 30; 5(1):643. PMID: 35773333.
      Citations:    
    11. Shinoda K, Choe A, Hirahara K, Kiuchi M, Kokubo K, Ichikawa T, Hoki JS, Suzuki AS, Bose N, Appleton JA, Aroian RV, Schroeder FC, Sternberg PW, Nakayama T. Nematode ascarosides attenuate mammalian type 2 inflammatory responses. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). PMID: 35210367.
      Citations: 3     Fields:    Translation:Animals
    12. Bakshi M, Tuo W, Aroian RV, Zarlenga D. Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases. Parasit Vectors. 2021 Nov 19; 14(1):580. PMID: 34798906.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Soto ER, Rus F, Li H, Garceau C, Chicca J, Elfawal M, Gazzola D, Nielsen MK, Urban JF, Aroian RV, Ostroff GR. Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release. Foods. 2021 May 27; 10(6). PMID: 34071798.
      Citations:    
    14. Urban JF, Nielsen MK, Gazzola D, Xie Y, Beshah E, Hu Y, Li H, Rus F, Flanagan K, Draper A, Vakalapudi S, Li RW, Ostroff GR, Aroian RV. An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals. One Health. 2021 Jun; 12:100241. PMID: 33889707.
      Citations:    
    15. Li H, Abraham A, Gazzola D, Hu Y, Beamer G, Flanagan K, Soto E, Rus F, Mirza Z, Draper A, Vakalapudi S, Stockman C, Bain P, Urban JF, Ostroff GR, Aroian RV. Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans. Antimicrob Agents Chemother. 2021 02 17; 65(3). PMID: 33318013.
      Citations: 3     Fields:    Translation:HumansAnimals
    16. Sanders J, Xie Y, Gazzola D, Li H, Abraham A, Flanagan K, Rus F, Miller M, Hu Y, Guynn S, Draper A, Vakalapudi S, Petersson KH, Zarlenga D, Li RW, Urban JF, Ostroff GR, Zajac A, Aroian RV. A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep. Int J Parasitol Drugs Drug Resist. 2020 12; 14:230-236. PMID: 33242790.
      Citations: 8     Fields:    Translation:Animals
    17. Mirza Z, Soto ER, Hu Y, Nguyen TT, Koch D, Aroian RV, Ostroff GR. Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes. Molecules. 2020 Jun 27; 25(13). PMID: 32605043.
      Citations: 10     Fields:    Translation:HumansAnimals
    18. Liu F, Xie Y, Zajac AM, Hu Y, Aroian RV, Urban JF, Li RW. Gut microbial signatures associated with moxidectin treatment efficacy of Haemonchus contortus in infected goats. Vet Microbiol. 2020 Mar; 242:108607. PMID: 32122611.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Charuchaibovorn S, Sanprasert V, Sutthanont N, Hu Y, Abraham A, Ostroff GR, Aroian RV, Jaleta TG, Lok JB, Nuchprayoon S. Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro. Am J Trop Med Hyg. 2019 11; 101(5):1177-1182. PMID: 31516117.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Elfawal MA, Savinov SN, Aroian RV. Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes. Sci Rep. 2019 08 26; 9(1):12347. PMID: 31451730.
      Citations: 17     Fields:    Translation:Animals
    21. Tyagi R, Elfawal MA, Wildman SA, Helander J, Bulman CA, Sakanari J, Rosa BA, Brindley PJ, Janetka JW, Aroian RV, Mitreva M. Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. Sci Rep. 2019 06 24; 9(1):9085. PMID: 31235822.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Pan SC, Ward DV, Yin Y, Hu Y, Elfawal MA, Clark RE, Aroian RV. Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters. Sci Rep. 2019 05 27; 9(1):7868. PMID: 31133690.
      Citations: 5     Fields:    Translation:HumansAnimals
    23. Noon JB, Schwarz EM, Ostroff GR, Aroian RV. A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection. PLoS Negl Trop Dis. 2019 04; 13(4):e0007345. PMID: 31009474.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    24. Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. PLoS Negl Trop Dis. 2018 05; 12(5):e0006506. PMID: 29775454.
      Citations: 11     Fields:    Translation:HumansAnimals
    25. Tyagi R, Maddirala AR, Elfawal M, Fischer C, Bulman CA, Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley PJ, Tseng CC, Greig IR, Sakanari J, Wildman SA, Aroian R, Janetka JW, Mitreva M. Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics. ACS Infect Dis. 2018 07 13; 4(7):1130-1145. PMID: 29718656.
      Citations: 8     Fields:    Translation:AnimalsCells
    26. Hu Y, Nguyen TT, Lee ACY, Urban JF, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018 08; 8(2):287-294. PMID: 29772478.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Papaiakovou M, Pilotte N, Baumer B, Grant J, Asbjornsdottir K, Schaer F, Hu Y, Aroian R, Walson J, Williams SA. A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen. PLoS Negl Trop Dis. 2018 01; 12(1):e0006130. PMID: 29346412.
      Citations: 27     Fields:    Translation:HumansAnimals
    28. Noon JB, Aroian RV. Recombinant subunit vaccines for soil-transmitted helminths. Parasitology. 2017 Dec; 144(14):1845-1870. PMID: 28770689.
      Citations: 18     Fields:    Translation:Animals
    29. Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 2017 Feb; 13(2):371-385. PMID: 27875098.
      Citations: 25     Fields:    Translation:AnimalsCells
    30. Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, Hughes J, Wegener A, Aroian RV, Narva KE, Berry C. The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. BMC Biol. 2016 08 30; 14:71. PMID: 27576487.
      Citations: 15     Fields:    Translation:AnimalsCells
    31. Durmaz E, Hu Y, Aroian RV, Klaenhammer TR. Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic. Appl Environ Microbiol. 2016 02 15; 82(4):1286-94. PMID: 26682852.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. von Hoven G, Neukirch C, Meyenburg M, F?ser S, Petrivna MB, Rivas AJ, Ryazanov A, Kaufman RJ, Aroian RV, Husmann M. eIF2a Confers Cellular Tolerance to S. aureus a-Toxin. Front Immunol. 2015; 6:383. PMID: 26284068.
      Citations: 3     Fields:    
    33. Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV. Erratum: the genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families. Nat Genet. 2015 Jun; 47(6):689. PMID: 26018900.
      Citations:    Fields:    
    34. Wu CC, Hu Y, Miller M, Aroian RV, Sailor MJ. Protection and Delivery of Anthelmintic Protein Cry5B to Nematodes Using Mesoporous Silicon Particles. ACS Nano. 2015 Jun 23; 9(6):6158-67. PMID: 25950754.
      Citations: 11     Fields:    Translation:Animals
    35. Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV. The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families. Nat Genet. 2015 Apr; 47(4):416-22. PMID: 25730766.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    36. Somvanshi VS, Ellis BL, Hu Y, Aroian RV. Nitazoxanide: nematicidal mode of action and drug combination studies. Mol Biochem Parasitol. 2014 Jan; 193(1):1-8. PMID: 24412397.
      Citations: 18     Fields:    Translation:Animals
    37. Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM. Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun. 2014 Mar; 82(3):1132-40. PMID: 24366250.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Hu Y, Ellis BL, Yiu YY, Miller MM, Urban JF, Shi LZ, Aroian RV. An extensive comparison of the effect of anthelmintic classes on diverse nematodes. PLoS One. 2013; 8(7):e70702. PMID: 23869246.
      Citations: 46     Fields:    Translation:Animals
    39. Hu Y, Miller MM, Derman AI, Ellis BL, Monnerat RG, Pogliano J, Aroian RV. Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases. Appl Environ Microbiol. 2013 Sep; 79(18):5527-32. PMID: 23835175.
      Citations: 14     Fields:    Translation:AnimalsCells
    40. Urban JF, Hu Y, Miller MM, Scheib U, Yiu YY, Aroian RV. Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. PLoS Negl Trop Dis. 2013; 7(6):e2263. PMID: 23818995.
      Citations: 21     Fields:    Translation:AnimalsCells
    41. Los FC, Randis TM, Aroian RV, Ratner AJ. Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev. 2013 Jun; 77(2):173-207. PMID: 23699254.
      Citations: 189     Fields:    Translation:HumansAnimals
    42. Los FC, Ha C, Aroian RV. Neuronal Goa and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins. PLoS One. 2013; 8(1):e54528. PMID: 23349920.
      Citations: 10     Fields:    Translation:AnimalsCells
    43. Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, Ghosh P. Structure and glycolipid binding properties of the nematicidal protein Cry5B. Biochemistry. 2012 Dec 11; 51(49):9911-21. PMID: 23150986.
      Citations: 31     Fields:    Translation:AnimalsCells
    44. Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl Trop Dis. 2012; 6(11):e1900. PMID: 23145203.
      Citations: 21     Fields:    Translation:Animals
    45. Hu Y, Aroian RV. Bacterial pore-forming proteins as anthelmintics. Invert Neurosci. 2012 Jun; 12(1):37-41. PMID: 22562659.
      Citations: 13     Fields:    Translation:Animals
    46. Kho MF, Bellier A, Balasubramani V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, Aroian RV. The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans. PLoS One. 2011; 6(12):e29122. PMID: 22216181.
      Citations: 23     Fields:    Translation:AnimalsCells
    47. Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog. 2011 Mar; 7(3):e1001314. PMID: 21408619.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    48. Los FC, Kao CY, Smitham J, McDonald KL, Ha C, Peixoto CA, Aroian RV. RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Cell Host Microbe. 2011 Feb 17; 9(2):147-57. PMID: 21320697.
      Citations: 78     Fields:    Translation:AnimalsCells
    49. Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Ba?uelos K, Romo-Fewell O, Aroian RV, Traver D. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010 Nov 11; 116(19):3944-54. PMID: 20713961.
      Citations: 68     Fields:    Translation:AnimalsCells
    50. Hu Y, Platzer EG, Bellier A, Aroian RV. Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5955-60. PMID: 20231450.
      Citations: 41     Fields:    Translation:HumansAnimals
    51. Hu Y, Georghiou SB, Kelleher AJ, Aroian RV. Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice. PLoS Negl Trop Dis. 2010 Mar 02; 4(3):e614. PMID: 20209154.
      Citations: 33     Fields:    Translation:Animals
    52. Chen CS, Bellier A, Kao CY, Yang YL, Chen HD, Los FC, Aroian RV. WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS One. 2010 Mar 02; 5(3):e9494. PMID: 20209166.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    53. Bellier A, Chen CS, Kao CY, Cinar HN, Aroian RV. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. PLoS Pathog. 2009 Dec; 5(12):e1000689. PMID: 20011506.
      Citations: 60     Fields:    Translation:Animals
    54. Hu Y, Xiao SH, Aroian RV. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11; 3(8):e499. PMID: 19668355.
      Citations: 45     Fields:    
    55. McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun. 2009; 1(5):494-506. PMID: 20375606.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    56. Kao CY, Los FC, Aroian RV. Nervous about immunity: neuronal signals control innate immune system. Nat Immunol. 2008 Dec; 9(12):1329-30. PMID: 19008931.
      Citations: 2     Fields:    Translation:AnimalsCells
    57. Bischof LJ, Kao CY, Los FC, Gonzalez MR, Shen Z, Briggs SP, van der Goot FG, Aroian RV. Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog. 2008 Oct; 4(10):e1000176. PMID: 18846208.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    58. Li XQ, Wei JZ, Tan A, Aroian RV. Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein. Plant Biotechnol J. 2007 Jul; 5(4):455-64. PMID: 17451491.
      Citations: 26     Fields:    Translation:AnimalsCells
    59. Barrows BD, Griffitts JS, Aroian RV. Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans. J Invertebr Pathol. 2007 Jul; 95(3):198-200. PMID: 17482642.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    60. Aroian R, van der Goot FG. Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol. 2007 Feb; 10(1):57-61. PMID: 17234446.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    61. Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. J Biol Chem. 2007 Feb 02; 282(5):3302-11. PMID: 17135259.
      Citations: 26     Fields:    Translation:Animals
    62. Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, Aroian RV. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15154-9. PMID: 17005719.
      Citations: 48     Fields:    Translation:AnimalsCells
    63. Barrows BD, Griffitts JS, Aroian RV. Caenorhabditis elegans carbohydrates in bacterial toxin resistance. Methods Enzymol. 2006; 417:340-58. PMID: 17132513.
      Citations: 11     Fields:    Translation:AnimalsCells
    64. Bischof LJ, Huffman DL, Aroian RV. Assays for toxicity studies in C. elegans with Bt crystal proteins. Methods Mol Biol. 2006; 351:139-54. PMID: 16988432.
      Citations: 52     Fields:    Translation:AnimalsCells
    65. Griffitts JS, Aroian RV. Many roads to resistance: how invertebrates adapt to Bt toxins. Bioessays. 2005 Jun; 27(6):614-24. PMID: 15892110.
      Citations: 47     Fields:    Translation:AnimalsCells
    66. Griffitts JS, Haslam SM, Yang T, Garczynski SF, Mulloy B, Morris H, Cremer PS, Dell A, Adang MJ, Aroian RV. Glycolipids as receptors for Bacillus thuringiensis crystal toxin. Science. 2005 Feb 11; 307(5711):922-5. PMID: 15705852.
      Citations: 111     Fields:    Translation:AnimalsCells
    67. Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, Aroian RV. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10995-1000. PMID: 15256590.
      Citations: 178     Fields:    Translation:AnimalsCells
    68. Huffman DL, Bischof LJ, Griffitts JS, Aroian RV. Pore worms: using Caenorhabditis elegans to study how bacterial toxins interact with their target host. Int J Med Microbiol. 2004 Apr; 293(7-8):599-607. PMID: 15149037.
      Citations: 22     Fields:    Translation:AnimalsCells
    69. Rappleye CA, Tagawa A, Le Bot N, Ahringer J, Aroian RV. Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. BMC Dev Biol. 2003 Oct 03; 3:8. PMID: 14527340.
      Citations: 40     Fields:    Translation:Animals
    70. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, M?ller R, Brown JR, Hennet T, Esko JD, Aroian RV. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem. 2003 Nov 14; 278(46):45594-602. PMID: 12944392.
      Citations: 52     Fields:    Translation:AnimalsCells
    71. Wei JZ, Hale K, Carta L, Platzer E, Wong C, Fang SC, Aroian RV. Bacillus thuringiensis crystal proteins that target nematodes. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2760-5. PMID: 12598644.
      Citations: 132     Fields:    Translation:AnimalsCells
    72. Rappleye CA, Tagawa A, Lyczak R, Bowerman B, Aroian RV. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Dev Cell. 2002 Feb; 2(2):195-206. PMID: 11832245.
      Citations: 40     Fields:    Translation:AnimalsCells
    73. Griffitts JS, Whitacre JL, Stevens DE, Aroian RV. Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme. Science. 2001 Aug 03; 293(5531):860-4. PMID: 11486087.
      Citations: 67     Fields:    Translation:AnimalsCellsPHPublic Health
    74. Tagawa A, Rappleye CA, Aroian RV. Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. Dev Biol. 2001 May 15; 233(2):412-24. PMID: 11336504.
      Citations: 27     Fields:    Translation:AnimalsCells
    75. Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Genetics. 2000 Aug; 155(4):1693-9. PMID: 10924467.
      Citations: 61     Fields:    Translation:AnimalsCells
    76. Rappleye CA, Paredez AR, Smith CW, McDonald KL, Aroian RV. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans. Genes Dev. 1999 Nov 01; 13(21):2838-51. PMID: 10557211.
      Citations: 40     Fields:    Translation:AnimalsCells
    77. Aroian RV, Field C, Pruliere G, Kenyon C, Alberts BM. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. EMBO J. 1997 Apr 01; 16(7):1541-9. PMID: 9130699.
      Citations: 14     Fields:    Translation:AnimalsCells
    78. Aroian RV, Lesa GM, Sternberg PW. Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function. EMBO J. 1994 Jan 15; 13(2):360-6. PMID: 8313880.
      Citations: 27     Fields:    Translation:AnimalsCells
    79. Aroian RV, Carta L, Kaloshian I, Sternberg PW. A Free-living Panagrolaimus sp. from Armenia Can Survive in Anhydrobiosis for 8.7 Years. J Nematol. 1993 Sep; 25(3):500-2. PMID: 19279802.
      Citations:    
    80. Aroian RV, Levy AD, Koga M, Ohshima Y, Kramer JM, Sternberg PW. Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site. Mol Cell Biol. 1993 Jan; 13(1):626-37. PMID: 8417357.
      Citations: 33     Fields:    Translation:AnimalsCells
    81. Aroian RV, Sternberg PW. Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics. 1991 Jun; 128(2):251-67. PMID: 2071015.
      Citations: 58     Fields:    Translation:Animals
    82. Han M, Aroian RV, Sternberg PW. The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans. Genetics. 1990 Dec; 126(4):899-913. PMID: 2076820.
      Citations: 62     Fields:    Translation:Animals
    83. Aroian RV, Koga M, Mendel JE, Ohshima Y, Sternberg PW. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature. 1990 Dec 20-27; 348(6303):693-9. PMID: 1979659.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    84. Russell CT, Aroian R, Arghavani M, Nock K. Interplanetary magnetic field enhancements and their association with the asteroid 2201 oljato. Science. 1984 Oct 05; 226(4670):43-5. PMID: 17815417.
      Citations: 1     Fields:    
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