Deoxyribonucleases, Type I Site-Specific
"Deoxyribonucleases, Type I Site-Specific" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
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Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 184.108.40.206 and EC 220.127.116.11 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 18.104.22.168.
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