Immunoglobulin A, Secretory

"Immunoglobulin A, Secretory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).

Descriptor ID	D007071
MeSH Number(s)	D12.776.124.486.485.114.619.026.030 D12.776.124.790.651.114.619.026.030 D12.776.377.715.548.114.619.026.030
Concept/Terms	Immunoglobulin A, Secretory Immunoglobulin A, Secretory Secretory IgA IgA, Exocrine Exocrine IgA SIgA IgA, Secretory Secretory Immunoglobulin A Colostral IgA Colostral IgA IgA, Colostral

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin A, Secretory".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Antibodies [D12.776.124.486.485.114]
Immunoglobulin Isotypes [D12.776.124.486.485.114.619]
Immunoglobulin A [D12.776.124.486.485.114.619.026]
Immunoglobulin A, Secretory [D12.776.124.486.485.114.619.026.030]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Antibodies [D12.776.124.790.651.114]
Immunoglobulin Isotypes [D12.776.124.790.651.114.619]
Immunoglobulin A [D12.776.124.790.651.114.619.026]
Immunoglobulin A, Secretory [D12.776.124.790.651.114.619.026.030]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Antibodies [D12.776.377.715.548.114]
Immunoglobulin Isotypes [D12.776.377.715.548.114.619]
Immunoglobulin A [D12.776.377.715.548.114.619.026]
Immunoglobulin A, Secretory [D12.776.377.715.548.114.619.026.030]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin A, Secretory".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin A, Secretory".

Immunoglobulin A, Secretory
Secretory Component

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin A, Secretory" by people in this website by year, and whether "Immunoglobulin A, Secretory" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2016	1	0	1
2019	1	0	1
2020	2	1	3
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Immunoglobulin A, Secretory" by people in Profiles.

Bajoria S, Antunez LR, Kumru OS, Klempner M, Wang Y, Cavacini LA, Joshi SB, Volkin DB. Formulation Studies to Develop Low-Cost, Orally-Delivered Secretory IgA Monoclonal Antibodies for Passive Immunization Against Enterotoxigenic Escherichia coli. J Pharm Sci. 2023 07; 112(7):1832-1844.

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Teh AY, Cavacini L, Hu Y, Kumru OS, Xiong J, Bolick DT, Joshi SB, Gr?nwald-Gruber C, Altmann F, Klempner M, Guerrant RL, Volkin DB, Wang Y, Ma JK. Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants. Gut Microbes. 2021 Jan-Dec; 13(1):1-14.

View in: PubMed
Ejemel M, Gawron MA, Schneider MI, Wallace A, Schiller ZA, Schneider R, Martin Iii JC, Klempner MS, Wang Y, Cavacini LA. Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A. Monoclon Antib Immunodiagn Immunother. 2020 Dec; 39(6):228-232.

View in: PubMed
Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Nat Commun. 2020 08 21; 11(1):4198.

View in: PubMed
Stoppato M, Gaspar C, Regeimbal J, Nunez RG, Giuntini S, Schiller ZA, Gawron MA, Pondish JR, Martin JC, Schneider MI, Klempner MS, Cavacini LA, Wang Y. Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model. Vaccine. 2020 02 28; 38(10):2333-2339.

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Hu Y, Kumru OS, Xiong J, Antunez LR, Hickey J, Wang Y, Cavacini L, Klempner M, Joshi SB, Volkin DB. Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration. J Pharm Sci. 2020 01; 109(1):407-421.

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Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.

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Fouda GG, Eudailey J, Kunz EL, Amos JD, Liebl BE, Himes J, Boakye-Agyeman F, Beck K, Michaels AJ, Cohen-Wolkowiez M, Haynes BF, Reimann KA, Permar SR. Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization. Mucosal Immunol. 2017 01; 10(1):228-237.

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Harris NL, Spoerri I, Schopfer JF, Nembrini C, Merky P, Massacand J, Urban JF, Lamarre A, Burki K, Odermatt B, Zinkernagel RM, Macpherson AJ. Mechanisms of neonatal mucosal antibody protection. J Immunol. 2006 Nov 01; 177(9):6256-62.

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Maaser C, Housley MP, Iimura M, Smith JR, Vallance BA, Finlay BB, Schreiber JR, Varki NM, Kagnoff MF, Eckmann L. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun. 2004 Jun; 72(6):3315-24.

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