"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D018741
|
| MeSH Number(s) |
G05.360.340.024.220.760 G05.360.340.024.745.725
|
| Concept/Terms |
Replication Origin- Replication Origin
- Origin, Replication
- Origins, Replication
- ori Region
- Region, ori
- Regions, ori
- ori Regions
- Origin of Replication
- Replication Origins
|
Below are MeSH descriptors whose meaning is more general than "Replication Origin".
Below are MeSH descriptors whose meaning is more specific than "Replication Origin".
This graph shows the total number of publications written about "Replication Origin" by people in this website by year, and whether "Replication Origin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 2 | 3 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 3 | 0 | 3 |
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Below are the most recent publications written about "Replication Origin" by people in Profiles.
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Rhind N. DNA replication timing: Biochemical mechanisms and biological significance. Bioessays. 2022 11; 44(11):e2200097.
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Emerson DJ, Zhao PA, Cook AL, Barnett RJ, Klein KN, Saulebekova D, Ge C, Zhou L, Simandi Z, Minsk MK, Titus KR, Wang W, Gong W, Zhang D, Yang L, Venev SV, Gibcus JH, Yang H, Sasaki T, Kanemaki MT, Yue F, Dekker J, Chen CL, Gilbert DM, Phillips-Cremins JE. Cohesin-mediated loop anchors confine the locations of human replication origins. Nature. 2022 06; 606(7915):812-819.
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Rhind N. f = m*a: A Framework for Investigating the Regulation of Replication Timing. Genes (Basel). 2022 01 28; 13(2).
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Wang W, Klein KN, Proesmans K, Yang H, Marchal C, Zhu X, Borrman T, Hastie A, Weng Z, Bechhoefer J, Chen CL, Gilbert DM, Rhind N. Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication. Mol Cell. 2021 07 15; 81(14):2975-2988.e6.
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Dukaj L, Rhind N. The capacity of origins to load MCM establishes replication timing patterns. PLoS Genet. 2021 03; 17(3):e1009467.
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Brossas C, Valton AL, Venev SV, Chilaka S, Counillon A, Laurent M, Goncalves C, Duriez B, Picard F, Dekker J, Prioleau MN. Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain. EMBO J. 2020 11 02; 39(21):e99520.
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Topal S, Van C, Xue Y, Carey MF, Peterson CL. INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins. Cell Rep. 2020 09 08; 32(10):108106.
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Mizuguchi T, Taneja N, Matsuda E, Belton JM, FitzGerald P, Dekker J, Grewal SIS. Shelterin components mediate genome reorganization in response to replication stress. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5479-5484.
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Azmi IF, Watanabe S, Maloney MF, Kang S, Belsky JA, MacAlpine DM, Peterson CL, Bell SP. Nucleosomes influence multiple steps during replication initiation. Elife. 2017 03 21; 6.
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Das SP, Rhind N. How and why multiple MCMs are loaded at origins of DNA replication. Bioessays. 2016 07; 38(7):613-7.