Guanylyl Imidodiphosphate
"Guanylyl Imidodiphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Descriptor ID |
D006165
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MeSH Number(s) |
D03.633.100.759.646.454.504.400 D13.695.667.454.504.400 D13.695.827.426.504.400
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Concept/Terms |
Guanylyl Imidodiphosphate- Guanylyl Imidodiphosphate
- Imidodiphosphate, Guanylyl
- Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
- Guanyl-5'-Imidodiphosphate
- Guanyl 5' Imidodiphosphate
- GMP-PNP
- P(NH)PPG
- GMP-P(NH)P
- Gpp(NH)p
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Below are MeSH descriptors whose meaning is more general than "Guanylyl Imidodiphosphate".
Below are MeSH descriptors whose meaning is more specific than "Guanylyl Imidodiphosphate".
This graph shows the total number of publications written about "Guanylyl Imidodiphosphate" by people in this website by year, and whether "Guanylyl Imidodiphosphate" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Guanylyl Imidodiphosphate" by people in Profiles.
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Ojamaa K, Klein I, Sabet A, Steinberg SF. Changes in adenylyl cyclase isoforms as a mechanism for thyroid hormone modulation of cardiac beta-adrenergic receptor responsiveness. Metabolism. 2000 Feb; 49(2):275-9.
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Dumas JJ, Zhu Z, Connolly JL, Lambright DG. Structural basis of activation and GTP hydrolysis in Rab proteins. Structure. 1999 Apr 15; 7(4):413-23.
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Stattel JM, Yanachkov I, Wright GE. Synthesis and biochemical study of N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(alpha,beta-imido)triphosphate (BuPdGMPNHPP): a non-substrate inhibitor of B family DNA polymerases. Nucleosides Nucleotides. 1998 Aug; 17(8):1505-13.
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Carraway RE, Mitra SP, Honeyman TW. Effects of GTP analogs and metal ions on the binding of neurotensin to porcine brain membranes. Peptides. 1993 Jan-Feb; 14(1):37-45.