Neoplasms, Second Primary

"Neoplasms, Second Primary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

Descriptor ID	D016609
MeSH Number(s)	C04.692
Concept/Terms	Neoplasms, Second Primary Neoplasms, Second Primary Neoplasm, Second Primary Second Primary Neoplasm Metachronous Second Primary Neoplasms Neoplasms, Metachronous Second Primary Neoplasms, Metachronous Second Malignancy Malignancies, Second Malignancy, Second Second Malignancies Second Neoplasm Neoplasm, Second Neoplasms, Second Second Neoplasms Second Primary Neoplasms Metachronous Neoplasms Metachronous Neoplasm Neoplasm, Metachronous Neoplasms, Metachronous Second Primary Neoplasms, Therapy-Associated Neoplasms, Therapy-Associated Neoplasm, Therapy-Associated Neoplasms, Therapy Associated Therapy-Associated Neoplasm Neoplasms, Treatment-Associated Neoplasm, Treatment-Associated Neoplasms, Treatment Associated Treatment-Associated Neoplasm Neoplasms, Treatment-Related Neoplasm, Treatment-Related Neoplasms, Treatment Related Treatment-Related Neoplasm Therapy-Related Neoplasms Therapy Related Neoplasms Treatment-Associated Neoplasms Treatment Associated Neoplasms Treatment-Related Neoplasms Treatment Related Neoplasms Neoplasms, Therapy-Related Neoplasm, Therapy-Related Neoplasms, Therapy Related Therapy-Related Neoplasm Therapy-Associated Neoplasms Therapy Associated Neoplasms Therapy-Associated Cancer Therapy-Associated Cancer Cancer, Therapy-Associated Cancers, Therapy-Associated Therapy Associated Cancer Therapy-Associated Cancers Therapy-Related Cancer Cancer, Therapy-Related Cancers, Therapy-Related Therapy Related Cancer Therapy-Related Cancers Treatment-Related Cancer Cancer, Treatment-Related Cancers, Treatment-Related Treatment Related Cancer Treatment-Related Cancers Treatment-Associated Cancer Cancer, Treatment-Associated Cancers, Treatment-Associated Treatment Associated Cancer Treatment-Associated Cancers Cancer, Second Primary Cancer, Second Primary Cancers, Second Primary Second Primary Cancer Second Primary Cancers Second Cancer Cancer, Second Cancers, Second Second Cancers

Below are MeSH descriptors whose meaning is more general than "Neoplasms, Second Primary".

Diseases [C]
Neoplasms [C04]
Neoplasms, Second Primary [C04.692]

Below are MeSH descriptors whose meaning is related to "Neoplasms, Second Primary".

Below are MeSH descriptors whose meaning is more specific than "Neoplasms, Second Primary".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neoplasms, Second Primary" by people in this website by year, and whether "Neoplasms, Second Primary" was a major or minor topic of these publications.

Bar chart showing 37 publications over 20 distinct years, with a maximum of 5 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1999	1	0	1
2000	1	0	1
2001	1	0	1
2004	3	0	3
2007	1	0	1
2008	3	0	3
2009	0	1	1
2011	0	2	2
2012	2	0	2
2014	3	2	5
2015	1	0	1
2016	2	1	3
2017	1	1	2
2018	1	0	1
2019	2	0	2
2020	2	0	2
2021	2	0	2
2023	2	0	2
2025	1	0	1

Below are the most recent publications written about "Neoplasms, Second Primary" by people in Profiles.

Patel SA, Spiegel JY, Dahiya S. Second Primary Cancer After Chimeric Antigen Receptor-T-Cell Therapy: A Review. JAMA Oncol. 2025 Feb 01; 11(2):174-181.

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Casey DL, Vogelius IR, Brodin NP, Roberts KB, Avanzo M, Moni J, Owens C, Ronckers CM, Constine LS, Bentzen SM, Olch A. Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A PENTEC Comprehensive Review. Int J Radiat Oncol Biol Phys. 2024 Jun 01; 119(2):640-654.

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Ragon BK, Shah MV, D'Souza A, Estrada-Merly N, Gowda L, George G, de Lima M, Hashmi S, Kharfan-Dabaja MA, Majhail NS, Banerjee R, Saad A, Hildebrandt GC, Mian H, Abid MB, Battiwalla M, Lekakis LJ, Patel SS, Murthy HS, Nieto Y, Strouse C, Badawy SM, Al Hadidi S, Dholaria B, Aljurf M, Vesole DH, Lee CH, Pawarode A, Gergis U, Miller KC, Holmberg LA, Afrough A, Solh M, Munshi PN, Nishihori T, Anderson LD, Wirk B, Kaur G, Qazilbash MH, Shah N, Kumar SK, Usmani SZ. Impact of second primary malignancy post-autologous transplantation on outcomes of multiple myeloma: a CIBMTR analysis. Blood Adv. 2023 06 27; 7(12):2746-2757.

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Schonfeld SJ, Kleinerman RA, Abramson DH, Seddon JM, Tucker MA, Morton LM. Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors. Br J Cancer. 2021 03; 124(7):1312-1319.

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Baker TG, Lyons MJ, Leddy L, Parham DM, Welsh CT. Epithelioid Sarcoma Arising in a Long-Term Survivor of an Atypical Teratoid/Rhabdoid Tumor in a Patient With Rhabdoid Tumor Predisposition Syndrome. Pediatr Dev Pathol. 2021 Mar-Apr; 24(2):164-168.

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Varlotto JM, Voland R, DeCamp MM, Rava P, Fitzgerald TJ, Maxfield M, Lou F, Oliveira P, Sood R, Baima J, Zhang J, McIntosh L, Rassaei N, Flickinger JC, Walsh W, Maddox D, Uy K. The rates of second lung cancers and the survival of surgically-resected second primary lung cancers in patients undergoing resection of an initial primary lung cancer. Lung Cancer. 2020 09; 147:115-122.

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Holstead R, Rasul R, Golden A, Kamdar D, Ghaly M, Teckie S, Frank D, Fantasia J, Seetharamu N. Identifying patterns of failure and secondary primary malignancies in HPV-related oropharyngeal squamous cell carcinomas. Future Oncol. 2020 Feb; 16(6):199-207.

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Kleinerman RA, Schonfeld SJ, Sigel BS, Wong-Siegel JR, Gilbert ES, Abramson DH, Seddon JM, Tucker MA, Morton LM. Bone and Soft-Tissue Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Treated With Radiation. J Clin Oncol. 2019 12 10; 37(35):3436-3445.

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Patel SA. Myelodysplastic Syndrome and Acute Myeloid Leukemia Risk Associated With Solid Tumor Chemotherapy. JAMA Oncol. 2019 03 01; 5(3):303-304.

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Li Y, Kulkarni M, Trinkaus K, Cornelius LA. Second primary melanomas: Increased risk and decreased time to presentation in patients exposed to tanning beds. J Am Acad Dermatol. 2018 Dec; 79(6):1101-1108.

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