Spectrometry, Mass, Electrospray Ionization
"Spectrometry, Mass, Electrospray Ionization" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
| Descriptor ID |
D021241
|
| MeSH Number(s) |
E05.196.566.600
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spectrometry, Mass, Electrospray Ionization".
Below are MeSH descriptors whose meaning is more specific than "Spectrometry, Mass, Electrospray Ionization".
This graph shows the total number of publications written about "Spectrometry, Mass, Electrospray Ionization" by people in this website by year, and whether "Spectrometry, Mass, Electrospray Ionization" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 2 | 1 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 3 | 3 | 6 |
| 2004 | 1 | 3 | 4 |
| 2005 | 1 | 2 | 3 |
| 2006 | 1 | 4 | 5 |
| 2007 | 3 | 5 | 8 |
| 2008 | 3 | 5 | 8 |
| 2009 | 1 | 3 | 4 |
| 2010 | 4 | 4 | 8 |
| 2011 | 0 | 5 | 5 |
| 2012 | 4 | 1 | 5 |
| 2013 | 2 | 2 | 4 |
| 2014 | 4 | 0 | 4 |
| 2015 | 2 | 2 | 4 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 4 | 0 | 4 |
| 2022 | 2 | 0 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spectrometry, Mass, Electrospray Ionization" by people in Profiles.
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Joseph KM, Boatman AK, Dodds JN, Kirkwood-Donelson KI, Ryan JP, Zhang J, Thiessen PA, Bolton EE, Valdiviezo A, Sapozhnikova Y, Rusyn I, Schymanski EL, Baker ES. Multidimensional library for the improved identification of per- and polyfluoroalkyl substances (PFAS). Sci Data. 2025 Jan 25; 12(1):150.
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Ivanov DG, Yang Y, Pawlowski JW, Carrick IJ, Kaltashov IA. Rapid Evaluation of the Extent of Haptoglobin Glycosylation Using Orthogonal Intact-Mass MS Approaches and Multivariate Analysis. Anal Chem. 2022 03 29; 94(12):5140-5148.
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Muneeruddin K, Kaltashov IA, Wang G. Characterizing Soluble Protein Aggregates Using Native Mass Spectrometry Coupled with Temperature-Controlled Electrospray Ionization and Size-Excl usion Chromatography. Methods Mol Biol. 2022; 2406:455-468.
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Foureau D, Bhutani M, Guo F, Rigby K, Leonidas M, Tjaden E, Fox A, Atrash S, Paul B, Voorhees PM, Usmani SZ. Comparison of mass spectrometry and flow cytometry in measuring minimal residual disease in multiple myeloma. Cancer Med. 2021 10; 10(20):6933-6936.
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Yang Y, Ivanov DG, Kaltashov IA. The challenge of structural heterogeneity in the native mass spectrometry studies of the SARS-CoV-2 spike protein interactions with its host cell-surface receptor. Anal Bioanal Chem. 2021 Dec; 413(29):7205-7214.
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Bobst CE, Sperry J, Friese OV, Kaltashov IA. Simultaneous Evaluation of a Vaccine Component Microheterogeneity and Conformational Integrity Using Native Mass Spectrometry and Limited Charge Reduction. J Am Soc Mass Spectrom. 2021 Jul 07; 32(7):1631-1637.
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Yang Y, Niu C, Bobst CE, Kaltashov IA. Charge Manipulation Using Solution and Gas-Phase Chemistry to Facilitate Analysis of Highly Heterogeneous Protein Complexes in Native Mass Spectrometry. Anal Chem. 2021 02 23; 93(7):3337-3342.
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Niu B, Mackness BC, Zitzewitz JA, Matthews CR, Gross ML. Trifluoroethanol Partially Unfolds G93A SOD1 Leading to Protein Aggregation: A Study by Native Mass Spectrometry and FPOP Protein Footprinting. Biochemistry. 2020 10 06; 59(39):3650-3659.
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Zhao B, Gao J, Serrano MAC, Arcaro KF, Thayumanavan S, Vachet RW. Polymeric nanoassemblies for enrichment and detection of peptides and proteins in human breast milk. Anal Bioanal Chem. 2020 Feb; 412(5):1027-1035.
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Wang G, Bondarenko PV, Kaltashov IA. Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry. Analyst. 2018 Feb 07; 143(3):670-677.