"Okadaic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)
| Descriptor ID |
D019319
|
| MeSH Number(s) |
D02.355.291.705
|
| Concept/Terms |
Okadaic Acid- Okadaic Acid
- Acid, Okadaic
- Ocadaic Acid
- Acid, Ocadaic
|
Below are MeSH descriptors whose meaning is more general than "Okadaic Acid".
Below are MeSH descriptors whose meaning is more specific than "Okadaic Acid".
This graph shows the total number of publications written about "Okadaic Acid" by people in this website by year, and whether "Okadaic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Okadaic Acid" by people in Profiles.
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Battistone MA, Da Ros VG, Salicioni AM, Navarrete FA, Krapf D, Visconti PE, Cuasnic? PS. Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases. Mol Hum Reprod. 2013 Sep; 19(9):570-80.
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Krapf D, Arcelay E, Wertheimer EV, Sanjay A, Pilder SH, Salicioni AM, Visconti PE. Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors. J Biol Chem. 2010 Mar 12; 285(11):7977-85.
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Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 2007 Apr 15; 100(6):1509-17.
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Fenton RA, Dickson EW, Dobson JG. Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci. 2005 Nov 12; 77(26):3375-88.
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Essler M, Amano M, Kruse HJ, Kaibuchi K, Weber PC, Aepfelbacher M. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. J Biol Chem. 1998 Aug 21; 273(34):21867-74.
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Macfarlane DE, Manzel L, Krieg AM. Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step. Immunology. 1997 Aug; 91(4):586-93.
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Moos J, Visconti PE, Moore GD, Schultz RM, Kopf GS. Potential role of mitogen-activated protein kinase in pronuclear envelope assembly and disassembly following fertilization of mouse eggs. Biol Reprod. 1995 Sep; 53(3):692-9.
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Schaefer OP, Ethier MF, Madison JM. Muscarinic regulation of cyclic AMP in bovine trachealis cells. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):217-26.
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Corvera S, Jaspers S, Pasceri M. Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid. J Biol Chem. 1991 May 15; 266(14):9271-5.