Granulomatous Disease, Chronic

"Granulomatous Disease, Chronic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.

Descriptor ID	D006105
MeSH Number(s)	C15.378.553.774.535 C16.320.322.233 C20.673.774.535
Concept/Terms	Granulomatous Disease, Chronic Granulomatous Disease, Chronic Chronic Granulomatous Diseases Granulomatous Diseases, Chronic Chronic Granulomatous Disease Autosomal Recessive Chronic Granulomatous Disease Autosomal Recessive Chronic Granulomatous Disease Granulomatous Disease, Chronic, X-Linked Granulomatous Disease, Chronic, X-Linked Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked X-Linked Chronic Granulomatous Disease X Linked Chronic Granulomatous Disease Granulomatous Disease, Chronic, X-Linked, Variant Chronic Granulomatous Disease, Atypical Chronic Granulomatous Disease, X-Linked Chronic Granulomatous Disease, X Linked Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked

Below are MeSH descriptors whose meaning is more general than "Granulomatous Disease, Chronic".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Leukocyte Disorders [C15.378.553]
Phagocyte Bactericidal Dysfunction [C15.378.553.774]
Granulomatous Disease, Chronic [C15.378.553.774.535]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Genetic Diseases, X-Linked [C16.320.322]
Granulomatous Disease, Chronic [C16.320.322.233]
Immune System Diseases [C20]
Immunologic Deficiency Syndromes [C20.673]
Phagocyte Bactericidal Dysfunction [C20.673.774]
Granulomatous Disease, Chronic [C20.673.774.535]

Below are MeSH descriptors whose meaning is related to "Granulomatous Disease, Chronic".

Below are MeSH descriptors whose meaning is more specific than "Granulomatous Disease, Chronic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulomatous Disease, Chronic" by people in this website by year, and whether "Granulomatous Disease, Chronic" was a major or minor topic of these publications.

Bar chart showing 17 publications over 14 distinct years, with a maximum of 2 publications in 1994 and 2001 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1995	1	0	1
1998	1	0	1
2000	1	0	1
2001	2	0	2
2004	1	0	1
2006	1	0	1
2007	0	1	1
2008	0	1	1
2011	1	0	1
2017	0	1	1
2018	2	0	2
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "Granulomatous Disease, Chronic" by people in Profiles.

Kohn DB, Booth C, Kang EM, Pai SY, Shaw KL, Santilli G, Armant M, Buckland KF, Choi U, De Ravin SS, Dorsey MJ, Kuo CY, Leon-Rico D, Rivat C, Izotova N, Gilmour K, Snell K, Dip JX, Darwish J, Morris EC, Terrazas D, Wang LD, Bauser CA, Paprotka T, Kuhns DB, Gregg J, Raymond HE, Everett JK, Honnet G, Biasco L, Newburger PE, Bushman FD, Grez M, Gaspar HB, Williams DA, Malech HL, Galy A, Thrasher AJ. Lentiviral gene therapy for X-linked chronic granulomatous disease. Nat Med. 2020 02; 26(2):200-206.

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Edelmayer L, Ito C, Lee WS, Kimbrough J, Kountakis SE, Byrd JK. Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence. Laryngoscope. 2019 11; 129(11):2447-2450.

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Fraz?o JB, Colombo M, Simillion C, Bilican A, Keller I, W?thrich D, Zhu Z, Okoniewski MJ, Bruggmann R, Condino-Neto A, Newburger PE. Gene expression in chronic granulomatous disease and interferon-? receptor-deficient cells treated in vitro with interferon-?. J Cell Biochem. 2019 03; 120(3):4321-4332.

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Newburger PE. Comment on: Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in the Absence of Molecular Diagnosis. Scand J Immunol. 2018 01; 87(1):57.

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Kenny EF, Herzig A, Kr?ger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A. Diverse stimuli engage different neutrophil extracellular trap pathways. Elife. 2017 06 02; 6.

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de Oliveira-Junior EB, Bustamante J, Newburger PE, Condino-Neto A. The human NADPH oxidase: primary and secondary defects impairing the respiratory burst function and the microbicidal ability of phagocytes. Scand J Immunol. 2011 May; 73(5):420-7.

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Luengo-Blanco M, Prando C, Bustamante J, Arag?o-Filho WC, Pereira PV, Rehder J, Padden C, Casanova JL, Newburger PE, Condino-Neto A. Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes. Blood. 2008 Aug 15; 112(4):1453-60.

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Alexander BL, Ali RR, Alton EW, Bainbridge JW, Braun S, Cheng SH, Flotte TR, Gaspar HB, Grez M, Griesenbach U, Kaplitt MG, Ott MG, Seger R, Simons M, Thrasher AJ, Thrasher AZ, Yl?-Herttuala S. Progress and prospects: gene therapy clinical trials (part 1). Gene Ther. 2007 Oct; 14(20):1439-47.

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Agudelo-Fl?rez P, Prando-Andrade CC, L?pez JA, Costa-Carvalho BT, Quezada A, Espinosa FJ, de Souza Paiva MA, Roxo P, Grumach A, Jacob CA, Carneiro-Sampaio MM, Newburger PE, Condino-Neto A. Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular genetics. Pediatr Blood Cancer. 2006 Feb; 46(2):243-52.

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Agudelo-Fl?rez P, Costa-Carvalho BT, L?pez JA, Redher J, Newburger PE, Olalla-Saad ST, Condino-Neto A. Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections. Am J Hematol. 2004 Mar; 75(3):151-6.

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