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Elinor Kathryn Karlsson PhD

TitleAssociate Professor
Endowed TitleDr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research
InstitutionUMass Chan Medical School
DepartmentGenomics and Computational Biology
AddressUMass Chan Medical School
368 Plantation Street AS4.1065
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGenomics and Computational Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentSystems Computational and Quantitative Biology


    Collapse Biography 
    Collapse education and training
    Rice University, Houston, TX, United StatesBABiochemistry & Cell Biology
    Boston University, Boston, MA, United StatesPHDBioinformatics

    Collapse Overview 
    Collapse overview


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lord KA, Larson G, Allaby RG, Karlsson EK. A universally applicable definition for domestication. Proc Natl Acad Sci U S A. 2025 Jun 03; 122(22):e2413207122. PMID: 40372471.
      Citations:    
    2. Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, B?ckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, B?rte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, H?ffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Ros?rio MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Artigas MS, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Land?n M, Hellard SL, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, B?rglum AD, Walitza S, Hveem K, Hansen BK, R?ck C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribas?s M, Kvale G, Mataix-Cols D, Domschke K, Gr?nblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. Nat Genet. 2025 Jun; 57(6):1389-1401. PMID: 40360802.
      Citations:    
    3. Gutmann DH, Boehm JS, Karlsson EK, Padron E, Seshadri M, Wallis D, Snyder JC. Precision preclinical modeling to advance cancer treatment. J Natl Cancer Inst. 2025 Apr 01; 117(4):586-594. PMID: 39383197.
      Citations:    
    4. Gynning BE, Karlsson E, Teoh K, Gustavsson P, Christiansen F, Brulin E. Contextualising the job demands-resources model: a cross-sectional study of the psychosocial work environment across different healthcare professions. Hum Resour Health. 2024 11 19; 22(1):77. PMID: 39563348.
      Citations:    
    5. Halvorsen MW, de Schipper E, B?ckman J, Strom NI, Hagen K, Lindblad-Toh K, Karlsson EK, Pedersen NL, Wallert J, Bulik CM, Fund?n B, Land?n M, Kvale G, Hansen B, Haavik J, Mattheisen M, R?ck C, Mataix-Cols D, Crowley JJ. A burden of rare copy number variants in obsessive-compulsive disorder. Mol Psychiatry. 2025 Apr; 30(4):1510-1517. PMID: 39463448.
      Citations:    
    6. Lord KA, Chen FL, Karlsson EK. An Evolutionary Perspective on Dog Behavioral Genetics. Annu Rev Anim Biosci. 2025 Feb; 13(1):167-188. PMID: 39413150.
      Citations:    
    7. Megquier K, Husted C, Rhoades J, White ME, Genereux DP, Chen FL, Xiong K, Kwon E, Swofford R, Painter C, Adalsteinsson V, London CA, Gardner HL, Karlsson EK. Impact of preanalytical factors on liquid biopsy in the canine cancer model. bioRxiv. 2024 Jul 30. PMID: 39131379.
      Citations:    
    8. Fernemark H, H?rdstedt M, Skagerstr?m J, Seing I, Karlsson E, Nilsen P, Schildmeijer KGI. Primary healthcare in the aftermath of the COVID-19 pandemic: a qualitative interview study in Sweden. BMJ Open. 2024 07 27; 14(7):e085527. PMID: 39067889.
      Citations:    
    9. Wirthlin ME, Schmid TA, Elie JE, Zhang X, Kowalczyk A, Redlich R, Shvareva VA, Rakuljic A, Ji MB, Bhat NS, Kaplow IM, Sch?ffer DE, Lawler AJ, Wang AZ, Phan BN, Annaldasula S, Brown AR, Lu T, Lim BK, Azim E, Clark NL, Meyer WK, Pond SLK, Chikina M, Yartsev MM, Pfenning AR, Andrews G, Armstrong JC, Bianchi M, Birren BW, Bredemeyer KR, Breit AM, Christmas MJ, Clawson H, Damas J, Di Palma F, Diekhans M, Dong MX, Eizirik E, Fan K, Fanter C, Foley NM, Forsberg-Nilsson K, Garcia CJ, Gatesy J, Gazal S, Genereux DP, Goodman L, Grimshaw J, Halsey MK, Harris AJ, Hickey G, Hiller M, Hindle AG, Hubley RM, Hughes GM, Johnson J, Juan D, Kaplow IM, Karlsson EK, Keough KC, Kirilenko B, Koepfli KP, Korstian JM, Kowalczyk A, Kozyrev SV, Lawler AJ, Lawless C, Lehmann T, Levesque DL, Lewin HA, Li X, Lind A, Lindblad-Toh K, Mackay-Smith A, Marinescu VD, Marques-Bonet T, Mason VC, Meadows JRS, Meyer WK, Moore JE, Moreira LR, Moreno-Santillan DD, Morrill KM, Muntan? G, Murphy WJ, Navarro A, Nweeia M, Ortmann S, Osmanski A, Paten B, Paulat NS, Pfenning AR, Phan BN, Pollard KS, Pratt HE, Ray DA, Reilly SK, Rosen JR, Ruf I, Ryan L, Ryder OA, Sabeti PC, Sch?ffer DE, Serres A, Shapiro B, Smit AFA, Springer M, Srinivasan C, Steiner C, Storer JM, Sullivan KAM, Sullivan PF, Sundstr?m E, Supple MA, Swofford R, Talbot JE, Teeling E, Turner-Maier J, Valenzuela A, Wagner F, Wallerman O, Wang C, Wang J, Weng Z, Wilder AP, Wirthlin ME, Xue JR, Zhang X. Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements. Science. 2024 03 29; 383(6690):eabn3263. PMID: 38422184.
      Citations:    
    10. Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Boberg J, B?rte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, German C, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, H?ffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Ros?rio MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LGSG, Smit J, Soler AM, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Land?n M, Le Hellard S, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, B?rglum AD, Walitza S, Hveem K, Hansen BK, R?ck CP, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribas?s M, Kvale G, Mataix-Cols D, Domschke K, Gr?nblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci. medRxiv. 2024 Mar 13. PMID: 38712091.
      Citations:    
    11. Strom NI, Halvorsen MW, Tian C, R?ck C, Kvale G, Hansen B, Bybjerg-Grauholm J, Grove J, Boberg J, Nissen JB, Damm Als T, Werge T, de Schipper E, Fundin B, Hultman C, H?ffler KD, Pedersen N, Sandin S, Bulik C, Land?n M, Karlsson E, Hagen K, Lindblad-Toh K, Hougaard DM, Meier SM, Hellard SL, Mors O, B?rglum AD, Haavik J, Hinds DA, Mataix-Cols D, Crowley JJ, Mattheisen M. Genome-wide association study identifies new loci associated with OCD. medRxiv. 2024 Mar 08. PMID: 38496634.
      Citations:    
    12. Ye W, Krishna Behra PR, Dyrhage K, Seeger C, Joiner JD, Karlsson E, Andersson E, Chi CN, Andersson SGE, Jemth P. Folded Alpha Helical Putative New Proteins from Apilactobacillus kunkeei. J Mol Biol. 2024 03 15; 436(6):168490. PMID: 38355092.
      Citations:    
    13. Kotliar D, Raju S, Tabrizi S, Odia I, Goba A, Momoh M, Sandi JD, Nair P, Phelan E, Tariyal R, Eromon PE, Mehta S, Robles-Sikisaka R, Siddle KJ, Stremlau M, Jalloh S, Gire SK, Winnicki S, Chak B, Schaffner SF, Pauthner M, Karlsson EK, Chapin SR, Kennedy SG, Branco LM, Kanneh L, Vitti JJ, Broodie N, Gladden-Young A, Omoniwa O, Jiang PP, Yozwiak N, Heuklom S, Moses LM, Akpede GO, Asogun DA, Rubins K, Kales S, Happi AN, Iruolagbe CO, Dic-Ijiewere M, Iraoyah K, Osazuwa OO, Okonkwo AK, Kunz S, McCormick JB, Khan SH, Honko AN, Lander ES, Oldstone MBA, Hensley L, Folarin OA, Okogbenin SA, G?nther S, Ollila HM, Tewhey R, Okokhere PO, Schieffelin JS, Andersen KG, Reilly SK, Grant DS, Garry RF, Barnes KG, Happi CT, Sabeti PC. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nat Microbiol. 2024 Mar; 9(3):751-762. PMID: 38326571.
      Citations:    Fields:    
    14. Nam Y, White M, Karlsson EK, Creevy KE, Promislow DEL, McClelland RL. Dog size and patterns of disease history across the canine age spectrum: Results from the Dog Aging Project. PLoS One. 2024; 19(1):e0295840. PMID: 38232117.
      Citations: 1     Fields:    Translation:Animals
    15. Halvorsen M, de Schipper E, Boberg J, Strom N, Hagen K, Lindblad-Toh K, Karlsson E, Pedersen N, Bulik C, Fund?n B, Land?n M, Kvale G, Hansen B, Haavik J, Mattheisen M, R?ck C, Mataix-Cols D, Crowley J. A Burden of Rare Copy Number Variants in Obsessive-Compulsive Disorder. Res Sq. 2024 Jan 03. PMID: 38260575.
      Citations:    
    16. Karlsson E, Ottoson C, Ye W, Andersson E, Jemth P. Intrinsically Disordered Flanking Regions Increase the Affinity of a Transcriptional Coactivator Interaction across Vertebrates. Biochemistry. 2023 09 19; 62(18):2710-2716. PMID: 37647499.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    17. Morrill K, Chen F, Karlsson E. Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics. Hum Genet. 2023 Aug; 142(8):1231-1246. PMID: 37578529.
      Citations:    Fields:    Translation:HumansAnimals
    18. Roy A, Sakthikumar S, Kozyrev SV, Nordin J, Pensch R, M?kel?inen S, Pettersson M, Karlsson EK, Lindblad-Toh K, Forsberg-Nilsson K. Using evolutionary constraint to define novel candidate driver genes in medulloblastoma. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2300984120. PMID: 37549291.
      Citations:    Fields:    Translation:HumansAnimals
    19. Paulat NS, Storer JM, Moreno-Santill?n DD, Osmanski AB, Sullivan KAM, Grimshaw JR, Korstian J, Halsey M, Garcia CJ, Crookshanks C, Roberts J, Smit AFA, Hubley R, Rosen J, Teeling EC, Vernes SC, Myers E, Pippel M, Brown T, Hiller M, Rojas D, D?valos LM, Lindblad-Toh K, Karlsson EK, Ray DA. Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia. Mol Biol Evol. 2023 05 02; 40(5). PMID: 37071810.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Wilder AP, Supple MA, Subramanian A, Mudide A, Swofford R, Serres-Armero A, Steiner C, Koepfli KP, Genereux DP, Karlsson EK, Lindblad-Toh K, Marques-Bonet T, Munoz Fuentes V, Foley K, Meyer WK, Ryder OA, Shapiro B. The contribution of historical processes to contemporary extinction risk in placental mammals. Science. 2023 04 28; 380(6643):eabn5856. PMID: 37104572.
      Citations: 6     Fields:    Translation:Animals
    21. Foley NM, Mason VC, Harris AJ, Bredemeyer KR, Damas J, Lewin HA, Eizirik E, Gatesy J, Karlsson EK, Lindblad-Toh K, Springer MS, Murphy WJ. A genomic timescale for placental mammal evolution. Science. 2023 04 28; 380(6643):eabl8189. PMID: 37104581.
      Citations: 13     Fields:    Translation:Animals
    22. Moon KL, Huson HJ, Morrill K, Wang MS, Li X, Srikanth K, Lindblad-Toh K, Svenson GJ, Karlsson EK, Shapiro B. ?Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs. Science. 2023 04 28; 380(6643):eabn5887. PMID: 37104591.
      Citations:    Fields:    Translation:Animals
    23. Xue JR, Mackay-Smith A, Mouri K, Garcia MF, Dong MX, Akers JF, Noble M, Li X, Lindblad-Toh K, Karlsson EK, Noonan JP, Capellini TD, Brennand KJ, Tewhey R, Sabeti PC, Reilly SK. The functional and evolutionary impacts of human-specific deletions in conserved elements. Science. 2023 04 28; 380(6643):eabn2253. PMID: 37104592.
      Citations: 5     Fields:    Translation:HumansCells
    24. Christmas MJ, Kaplow IM, Genereux DP, Dong MX, Hughes GM, Li X, Sullivan PF, Hindle AG, Andrews G, Armstrong JC, Bianchi M, Breit AM, Diekhans M, Fanter C, Foley NM, Goodman DB, Goodman L, Keough KC, Kirilenko B, Kowalczyk A, Lawless C, Lind AL, Meadows JRS, Moreira LR, Redlich RW, Ryan L, Swofford R, Valenzuela A, Wagner F, Wallerman O, Brown AR, Damas J, Fan K, Gatesy J, Grimshaw J, Johnson J, Kozyrev SV, Lawler AJ, Marinescu VD, Morrill KM, Osmanski A, Paulat NS, Phan BN, Reilly SK, Sch?ffer DE, Steiner C, Supple MA, Wilder AP, Wirthlin ME, Xue JR, Birren BW, Gazal S, Hubley RM, Koepfli KP, Marques-Bonet T, Meyer WK, Nweeia M, Sabeti PC, Shapiro B, Smit AFA, Springer MS, Teeling EC, Weng Z, Hiller M, Levesque DL, Lewin HA, Murphy WJ, Navarro A, Paten B, Pollard KS, Ray DA, Ruf I, Ryder OA, Pfenning AR, Lindblad-Toh K, Karlsson EK. Evolutionary constraint and innovation across hundreds of placental mammals. Science. 2023 04 28; 380(6643):eabn3943. PMID: 37104599.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    25. Kirilenko BM, Munegowda C, Osipova E, Jebb D, Sharma V, Blumer M, Morales AE, Ahmed AW, Kontopoulos DG, Hilgers L, Lindblad-Toh K, Karlsson EK, Hiller M. Integrating gene annotation with orthology inference at scale. Science. 2023 04 28; 380(6643):eabn3107. PMID: 37104600.
      Citations: 18     Fields:    Translation:Animals
    26. Keough KC, Whalen S, Inoue F, Przytycki PF, Fair T, Deng C, Steyert M, Ryu H, Lindblad-Toh K, Karlsson E, Nowakowski T, Ahituv N, Pollen A, Pollard KS. Three-dimensional genome rewiring in loci with human accelerated regions. Science. 2023 04 28; 380(6643):eabm1696. PMID: 37104607.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    27. Kaplow IM, Lawler AJ, Sch?ffer DE, Srinivasan C, Sestili HH, Wirthlin ME, Phan BN, Prasad K, Brown AR, Zhang X, Foley K, Genereux DP, Karlsson EK, Lindblad-Toh K, Meyer WK, Pfenning AR. Relating enhancer genetic variation across mammals to complex phenotypes using machine learning. Science. 2023 04 28; 380(6643):eabm7993. PMID: 37104615.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Osmanski AB, Paulat NS, Korstian J, Grimshaw JR, Halsey M, Sullivan KAM, Moreno-Santill?n DD, Crookshanks C, Roberts J, Garcia C, Johnson MG, Densmore LD, Stevens RD, Rosen J, Storer JM, Hubley R, Smit AFA, D?valos LM, Karlsson EK, Lindblad-Toh K, Ray DA. Insights into mammalian TE diversity through the curation of 248 genome assemblies. Science. 2023 04 28; 380(6643):eabn1430. PMID: 37104570.
      Citations: 6     Fields:    Translation:AnimalsCells
    29. Andrews G, Fan K, Pratt HE, Phalke N, Karlsson EK, Lindblad-Toh K, Gazal S, Moore JE, Weng Z. Mammalian evolution of human cis-regulatory elements and transcription factor binding sites. Science. 2023 04 28; 380(6643):eabn7930. PMID: 37104580.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    30. Sullivan PF, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wang C, Wallerman O, Xue J, Yao S, Sun Q, Szatkiewicz J, Wen J, Huckins LM, Lawler A, Keough KC, Zheng Z, Zeng J, Wray NR, Li Y, Johnson J, Chen J, Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K. Leveraging base-pair mammalian constraint to understand genetic variation and human disease. Science. 2023 04 28; 380(6643):eabn2937. PMID: 37104612.
      Citations: 13     Fields:    Translation:HumansAnimals
    31. Sullivan PF, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wallerman O, Xue JR, Li Y, Yao S, Sun Q, Szatkiewicz J, Wen J, Huckins LM, Lawler AJ, Keough KC, Zheng Z, Zeng J, Wray NR, Johnson J, Chen J, Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K. Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease. bioRxiv. 2023 Mar 10. PMID: 36945512.
      Citations:    
    32. Damas J, Corbo M, Kim J, Turner-Maier J, Farr? M, Larkin DM, Ryder OA, Steiner C, Houck ML, Hall S, Shiue L, Thomas S, Swale T, Daly M, Korlach J, Uliano-Silva M, Mazzoni CJ, Birren BW, Genereux DP, Johnson J, Lindblad-Toh K, Karlsson EK, Nweeia MT, Johnson RN, Lewin HA. Evolution of the ancestral mammalian karyotype and syntenic regions. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2209139119. PMID: 36161960.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. Megquier K, Turner-Maier J, Morrill K, Li X, Johnson J, Karlsson EK, London CA, Gardner HL. The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations. PLoS One. 2022; 17(9):e0274383. PMID: 36099278.
      Citations:    Fields:    Translation:AnimalsCells
    34. Karlsson E, Schnatwinkel J, Paissoni C, Andersson E, Herrmann C, Camilloni C, Jemth P. Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA. J Mol Biol. 2022 07 15; 434(13):167643. PMID: 35605677.
      Citations: 8     Fields:    Translation:Cells
    35. Morrill K, Hekman J, Li X, McClure J, Logan B, Goodman L, Gao M, Dong Y, Alonso M, Carmichael E, Snyder-Mackler N, Alonso J, Noh HJ, Johnson J, Koltookian M, Lieu C, Megquier K, Swofford R, Turner-Maier J, White ME, Weng Z, Colubri A, Genereux DP, Lord KA, Karlsson EK. Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science. 2022 04 29; 376(6592):eabk0639. PMID: 35482869.
      Citations: 33     Fields:    Translation:Animals
    36. Karlsson E, Sorgenfrei FA, Andersson E, Dogan J, Jemth P, Chi CN. The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved. Commun Biol. 2022 03 30; 5(1):286. PMID: 35354917.
      Citations:    
    37. Noh HJ, Turner-Maier J, Schulberg SA, Fitzgerald ML, Johnson J, Allen KN, H?ckst?dt LA, Batten AJ, Alfoldi J, Costa DP, Karlsson EK, Zapol WM, Buys ES, Lindblad-Toh K, Hindle AG. The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling. Commun Biol. 2022 02 17; 5(1):140. PMID: 35177770.
      Citations:    
    38. Blaxter M, Archibald JM, Childers AK, Coddington JA, Crandall KA, Di Palma F, Durbin R, Edwards SV, Graves JAM, Hackett KJ, Hall N, Jarvis ED, Johnson RN, Karlsson EK, Kress WJ, Kuraku S, Lawniczak MKN, Lindblad-Toh K, Lopez JV, Moran NA, Robinson GE, Ryder OA, Shapiro B, Soltis PS, Warnow T, Zhang G, Lewin HA. Why sequence all eukaryotes? Proc Natl Acad Sci U S A. 2022 01 25; 119(4). PMID: 35042801.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    39. Lewin HA, Richards S, Lieberman Aiden E, Allende ML, Archibald JM, B?lint M, Barker KB, Baumgartner B, Belov K, Bertorelle G, Blaxter ML, Cai J, Caperello ND, Carlson K, Castilla-Rubio JC, Chaw SM, Chen L, Childers AK, Coddington JA, Conde DA, Corominas M, Crandall KA, Crawford AJ, DiPalma F, Durbin R, Ebenezer TE, Edwards SV, Fedrigo O, Flicek P, Formenti G, Gibbs RA, Gilbert MTP, Goldstein MM, Graves JM, Greely HT, Grigoriev IV, Hackett KJ, Hall N, Haussler D, Helgen KM, Hogg CJ, Isobe S, Jakobsen KS, Janke A, Jarvis ED, Johnson WE, Jones SJM, Karlsson EK, Kersey PJ, Kim JH, Kress WJ, Kuraku S, Lawniczak MKN, Leebens-Mack JH, Li X, Lindblad-Toh K, Liu X, Lopez JV, Marques-Bonet T, Mazard S, Mazet JAK, Mazzoni CJ, Myers EW, O'Neill RJ, Paez S, Park H, Robinson GE, Roquet C, Ryder OA, Sabir JSM, Shaffer HB, Shank TM, Sherkow JS, Soltis PS, Tang B, Tedersoo L, Uliano-Silva M, Wang K, Wei X, Wetzer R, Wilson JL, Xu X, Yang H, Yoder AD, Zhang G. The Earth BioGenome Project 2020: Starting the clock. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). PMID: 35042800.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    40. Stephan T, Burgess SM, Cheng H, Danko CG, Gill CA, Jarvis ED, Koepfli KP, Koltes JE, Lyons E, Ronald P, Ryder OA, Schriml LM, Soltis P, VandeWoude S, Zhou H, Ostrander EA, Karlsson EK. Darwinian genomics and diversity in the tree of life. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). PMID: 35042807.
      Citations: 7     Fields:    Translation:HumansAnimals
    41. Karlsson E, Jakobsson JG. Emergencies in freestanding ambulatory surgery centre. Curr Opin Anaesthesiol. 2021 Dec 01; 34(6):690-694. PMID: 34560689.
      Citations:    Fields:    Translation:HumansPHPublic Health
    42. Lorenzana GP, Figueir? HV, Kaelin CB, Barsh GS, Johnson J, Karlsson E, Morato RG, Sana DA, Cullen L, May JA, Moraes EA, Kantek DLZ, Silveira L, Murphy WJ, Ryder OA, Eizirik E. Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar (Panthera onca) populations. J Genet Genomics. 2022 01; 49(1):77-80. PMID: 34767971.
      Citations: 1     Fields:    Translation:Animals
    43. Chen FL, Zimmermann M, Hekman JP, Lord KA, Logan B, Russenberger J, Leighton EA, Karlsson EK. Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science. Front Vet Sci. 2021; 8:662429. PMID: 34552971.
      Citations:    
    44. Herrera-?lvarez S, Karlsson E, Ryder OA, Lindblad-Toh K, Crawford AJ. How to Make a Rodent Giant: Genomic Basis and Tradeoffs of Gigantism in the Capybara, the World's Largest Rodent. Mol Biol Evol. 2021 05 04; 38(5):1715-1730. PMID: 33169792.
      Citations: 11     Fields:    Translation:Animals
    45. Kim JH, Megquier K, Thomas R, Sarver AL, Song JM, Kim YT, Cheng N, Schulte AJ, Linden MA, Murugan P, Oseth L, Forster CL, Elvers I, Swofford R, Turner-Maier J, Karlsson EK, Breen M, Lindblad-Toh K, Modiano JF. Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions. Mol Cancer Res. 2021 05; 19(5):847-861. PMID: 33649193.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    46. Hinde K, Amorim CEG, Brokaw AF, Burt N, Casillas MC, Chen A, Chestnut T, Connors PK, Dasari M, Ditelberg CF, Dietrick J, Drew J, Durgavich L, Easterling B, Henning C, Hilborn A, Karlsson EK, Kissel M, Kobylecky J, Krell J, Lee DN, Lesciotto KM, Lewton KL, Light JE, Martin J, Murphy A, Nickley W, N??ez-de la Mora A, Pellicer O, Pellicer V, Perry AM, Schuttler SG, Stone AC, Tanis B, Weber J, Wilson M, Willcocks E, Anderson CN. March Mammal Madness and the power of narrative in science outreach. Elife. 2021 02 22; 10. PMID: 33616530.
      Citations: 1     Fields:    Translation:HumansAnimals
    47. Karlsson E, Jemth P. Kinetic Methods of Deducing Binding Mechanisms Involving Intrinsically Disordered Proteins. Methods Mol Biol. 2021; 2263:105-133. PMID: 33877595.
      Citations:    Fields:    Translation:HumansCells
    48. Karlsson E, Paissoni C, Erkelens AM, Tehranizadeh ZA, Sorgenfrei FA, Andersson E, Ye W, Camilloni C, Jemth P. Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins. J Biol Chem. 2020 12 18; 295(51):17698-17712. PMID: 33454008.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    49. Armstrong J, Hickey G, Diekhans M, Fiddes IT, Novak AM, Deran A, Fang Q, Xie D, Feng S, Stiller J, Genereux D, Johnson J, Marinescu VD, Alf?ldi J, Harris RS, Lindblad-Toh K, Haussler D, Karlsson E, Jarvis ED, Zhang G, Paten B. Progressive Cactus is a multiple-genome aligner for the thousand-genome era. Nature. 2020 11; 587(7833):246-251. PMID: 33177663.
      Citations: 121     Fields:    Translation:HumansAnimals
    50. Lord KA, Larson G, Karlsson EK. Brain Size Does Not Rescue Domestication Syndrome. Trends Ecol Evol. 2020 12; 35(12):1061-1062. PMID: 33129589.
      Citations: 6     Fields:    Translation:Animals
    51. Damas J, Hughes GM, Keough KC, Painter CA, Persky NS, Corbo M, Hiller M, Koepfli KP, Pfenning AR, Zhao H, Genereux DP, Swofford R, Pollard KS, Ryder OA, Nweeia MT, Lindblad-Toh K, Teeling EC, Karlsson EK, Lewin HA. Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22311-22322. PMID: 32826334.
      Citations: 330     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    52. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 07 28; 32(4):107949. PMID: 32726638.
      Citations: 13     Fields:    Translation:AnimalsCells
    53. Lord KA, Larson G, Karlsson EK. Reply to Zeder and Trut et al.: An Attractive Hypothesis in Need of Evidence. Trends Ecol Evol. 2020 08; 35(8):651-652. PMID: 32517961.
      Citations: 3     Fields:    Translation:Animals
    54. Karlsson E, Lindberg A, Andersson E, Jemth P. High affinity between CREBBP/p300 and NCOA evolved in vertebrates. Protein Sci. 2020 07; 29(7):1687-1691. PMID: 32329110.
      Citations: 7     Fields:    Translation:AnimalsCells
    55. Damas J, Hughes GM, Keough KC, Painter CA, Persky NS, Corbo M, Hiller M, Koepfli KP, Pfenning AR, Zhao H, Genereux DP, Swofford R, Pollard KS, Ryder OA, Nweeia MT, Lindblad-Toh K, Teeling EC, Karlsson EK, Lewin HA. Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates. bioRxiv. 2020 Apr 18. PMID: 32511356.
      Citations:    
    56. Sykes N, Beirne P, Horowitz A, Jones I, Kalof L, Karlsson E, King T, Litwak H, McDonald RA, Murphy LJ, Pemberton N, Promislow D, Rowan A, Stahl PW, Tehrani J, Tourigny E, Wynne CDL, Strauss E, Larson G. Humanity's Best Friend: A Dog-Centric Approach to Addressing Global Challenges. Animals (Basel). 2020 Mar 17; 10(3). PMID: 32192138.
      Citations:    
    57. Chauhan G, McClure J, Hekman J, Marsh PW, Bailey JA, Daniels RF, Genereux DP, Karlsson EK. Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution. Front Genet. 2019; 10:1322. PMID: 32038704.
      Citations:    
    58. Laursen L, Karlsson E, Gianni S, Jemth P. Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95. J Biol Chem. 2020 02 14; 295(7):1992-2000. PMID: 31831623.
      Citations: 11     Fields:    Translation:HumansCells
    59. Lord KA, Larson G, Coppinger RP, Karlsson EK. The History of Farm Foxes Undermines the Animal Domestication Syndrome. Trends Ecol Evol. 2020 02; 35(2):125-136. PMID: 31810775.
      Citations: 40     Fields:    Translation:Animals
    60. Beichman AC, Koepfli KP, Li G, Murphy W, Dobrynin P, Kliver S, Tinker MT, Murray MJ, Johnson J, Lindblad-Toh K, Karlsson EK, Lohmueller KE, Wayne RK. Aquatic Adaptation and Depleted Diversity: A Deep Dive into the Genomes of the Sea Otter and Giant Otter. Mol Biol Evol. 2019 12 01; 36(12):2631-2655. PMID: 31212313.
      Citations: 24     Fields:    Translation:Animals
    61. Casewell NR, Petras D, Card DC, Suranse V, Mychajliw AM, Richards D, Koludarov I, Albulescu LO, Slagboom J, Hempel BF, Ngum NM, Kennerley RJ, Brocca JL, Whiteley G, Harrison RA, Bolton FMS, Debono J, Vonk FJ, Alf?ldi J, Johnson J, Karlsson EK, Lindblad-Toh K, Mellor IR, S?ssmuth RD, Fry BG, Kuruppu S, Hodgson WC, Kool J, Castoe TA, Barnes I, Sunagar K, Undheim EAB, Turvey ST. Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals. Proc Natl Acad Sci U S A. 2019 12 17; 116(51):25745-25755. PMID: 31772017.
      Citations: 26     Fields:    Translation:Animals
    62. Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, Scott MC, Schulte AJ, Borst L, Tonomura N, Alfoldi J, Painter C, Thomas R, Karlsson EK, Breen M, Modiano JF, Elvers I, Lindblad-Toh K. Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Mol Cancer Res. 2019 12; 17(12):2410-2421. PMID: 31570656.
      Citations: 33     Fields:    Translation:HumansAnimals
    63. Mataix-Cols D, Hansen B, Mattheisen M, Karlsson EK, Addington AM, Boberg J, Djurfeldt DR, Halvorsen M, Lichtenstein P, Solem S, Lindblad-Toh K, Haavik J, Kvale G, R?ck C, Crowley JJ. Nordic OCD & Related Disorders Consortium: Rationale, design, and methods. Am J Med Genet B Neuropsychiatr Genet. 2020 01; 183(1):38-50. PMID: 31424634.
      Citations: 8     Fields:    Translation:Humans
    64. Karlsson E, Andersson E, Jones NC, Hoffmann SV, Jemth P, Kjaergaard M. Coupled Binding and Helix Formation Monitored by Synchrotron-Radiation Circular Dichroism. Biophys J. 2019 08 20; 117(4):729-742. PMID: 31378314.
      Citations: 2     Fields:    Translation:HumansCells
    65. Megquier K, Genereux DP, Hekman J, Swofford R, Turner-Maier J, Johnson J, Alonso J, Li X, Morrill K, Anguish LJ, Koltookian M, Logan B, Sharp CR, Ferrer L, Lindblad-Toh K, Meyers-Wallen VN, Hoffman A, Karlsson EK. BarkBase: Epigenomic Annotation of Canine Genomes. Genes (Basel). 2019 06 07; 10(6). PMID: 31181663.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    66. Hindle AG, Allen KN, Batten AJ, H?ckst?dt LA, Turner-Maier J, Schulberg SA, Johnson J, Karlsson E, Lindblad-Toh K, Costa DP, Bloch DB, Zapol WM, Buys ES. Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving. Am J Physiol Regul Integr Comp Physiol. 2019 06 01; 316(6):R704-R715. PMID: 30892912.
      Citations: 6     Fields:    Translation:AnimalsCells
    67. Karlsson E, Andersson E, Dogan J, Gianni S, Jemth P, Camilloni C. A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins. J Biol Chem. 2019 01 25; 294(4):1230-1239. PMID: 30514761.
      Citations: 19     Fields:    Translation:HumansCells
    68. Jemth P, Karlsson E, V?geli B, Guzovsky B, Andersson E, Hultqvist G, Dogan J, G?ntert P, Riek R, Chi CN. Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins. Sci Adv. 2018 10; 4(10):eaau4130. PMID: 30397651.
      Citations: 21     Fields:    Translation:HumansCells
    69. Goodman L, Karlsson EK. America's lost dogs. Science. 2018 07 06; 361(6397):27-28. PMID: 29976811.
      Citations: 1     Fields:    Translation:Animals
    70. Moses L, Niemi S, Karlsson E. Pet genomics medicine runs wild. Nature. 2018 07; 559(7715):470-472. PMID: 30046086.
      Citations: 11     Fields:    Translation:HumansAnimals
    71. Palkopoulou E, Lipson M, Mallick S, Nielsen S, Rohland N, Baleka S, Karpinski E, Ivancevic AM, To TH, Kortschak RD, Raison JM, Qu Z, Chin TJ, Alt KW, Claesson S, Dal?n L, MacPhee RDE, Meller H, Roca AL, Ryder OA, Heiman D, Young S, Breen M, Williams C, Aken BL, Ruffier M, Karlsson E, Johnson J, Di Palma F, Alfoldi J, Adelson DL, Mailund T, Munch K, Lindblad-Toh K, Hofreiter M, Poinar H, Reich D. A comprehensive genomic history of extinct and living elephants. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):E2566-E2574. PMID: 29483247.
      Citations: 55     Fields:    Translation:Animals
    72. Bourque DL, Bhuiyan TR, Genereux DP, Rashu R, Ellis CN, Chowdhury F, Khan AI, Alam NH, Paul A, Hossain L, Mayo-Smith LM, Charles RC, Weil AA, LaRocque RC, Calderwood SB, Ryan ET, Karlsson EK, Qadri F, Harris JB. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun. 2018 02; 86(2). PMID: 29133347.
      Citations: 16     Fields:    Translation:HumansCells
    73. Noh HJ, Tang R, Flannick J, O'Dushlaine C, Swofford R, Howrigan D, Genereux DP, Johnson J, van Grootheest G, Gr?nblatt E, Andersson E, Djurfeldt DR, Patel PD, Koltookian M, M Hultman C, Pato MT, Pato CN, Rasmussen SA, Jenike MA, Hanna GL, Stewart SE, Knowles JA, Ruhrmann S, Grabe HJ, Wagner M, R?ck C, Mathews CA, Walitza S, Cath DC, Feng G, Karlsson EK, Lindblad-Toh K. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nat Commun. 2017 10 17; 8(1):774. PMID: 29042551.
      Citations: 30     Fields:    Translation:HumansCells
    74. Al-Mamun MM, Sarker SK, Qadri SK, Shirin T, Mohammad QD, LaRocque R, Karlsson EK, Saha N, Asaduzzaman M, Qadri F, Mannoor MK. Examination of Huntington's disease with atypical clinical features in a Bangladeshi family tree. Clin Case Rep. 2016 12; 4(12):1191-1194. PMID: 27980761.
      Citations:    
    75. Vieira NM, Elvers I, Alexander MS, Moreira YB, Eran A, Gomes JP, Marshall JL, Karlsson EK, Verjovski-Almeida S, Lindblad-Toh K, Kunkel LM, Zatz M. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Cell. 2015 Nov 19; 163(5):1204-1213. PMID: 26582133.
      Citations: 75     Fields:    Translation:AnimalsCells
    76. Kamberov YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, Tabin CJ. A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9932-7. PMID: 26195765.
      Citations: 24     Fields:    Translation:AnimalsCells
    77. Bostner J, Karlsson E, Eding CB, Perez-Tenorio G, Franz?n H, Konstantinell A, Fornander T, Nordenskj?ld B, St?l O. S6 kinase signaling: tamoxifen response and prognostic indication in two breast cancer cohorts. Endocr Relat Cancer. 2015 Jun; 22(3):331-43. PMID: 25972244.
      Citations: 12     Fields:    Translation:HumansCells
    78. Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K. Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet. 2015 Feb; 11(2):e1004922. PMID: 25642983.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    79. Ellis CN, LaRocque RC, Uddin T, Krastins B, Mayo-Smith LM, Sarracino D, Karlsson EK, Rahman A, Shirin T, Bhuiyan TR, Chowdhury F, Khan AI, Ryan ET, Calderwood SB, Qadri F, Harris JB. Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera. Infect Immun. 2015 Mar; 83(3):1089-103. PMID: 25561705.
      Citations: 37     Fields:    Translation:HumansCells
    80. Baranowska K?rberg I, Sundstr?m E, Meadows JR, Rosengren Pielberg G, Gustafson U, Hedhammar ?, Karlsson EK, Seddon J, S?derberg A, Vil? C, Zhang X, ?kesson M, Lindblad-Toh K, Andersson G, Andersson L. A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs. PLoS One. 2014; 9(8):e104363. PMID: 25116146.
      Citations: 28     Fields:    Translation:AnimalsCells
    81. Karlsson EK, Kwiatkowski DP, Sabeti PC. Natural selection and infectious disease in human populations. Nat Rev Genet. 2014 Jun; 15(6):379-93. PMID: 24776769.
      Citations: 190     Fields:    Translation:Humans
    82. Tang R, Noh HJ, Wang D, Sigurdsson S, Swofford R, Perloski M, Duxbury M, Patterson EE, Albright J, Castelhano M, Auton A, Boyko AR, Feng G, Lindblad-Toh K, Karlsson EK. Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol. 2014 Mar 14; 15(3):R25. PMID: 24995881.
      Citations: 46     Fields:    Translation:AnimalsCells
    83. Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, Ricketts SL, Mandlebaum S, Rivera P, von Euler H, Kisseberth WC, London CA, Lander ES, Couto G, Comstock K, Starkey MP, Modiano JF, Breen M, Lindblad-Toh K. Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol. 2013 Dec 12; 14(12):R132. PMID: 24330828.
      Citations: 81     Fields:    Translation:HumansAnimals
    84. Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N, O'Dushlaine C, Schaffner SF, Gupta S, Chowdhury F, Sheikh A, Shin OS, Ellis C, Becker CE, Stuart LM, Calderwood SB, Ryan ET, Qadri F, Sabeti PC, Larocque RC. Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Sci Transl Med. 2013 Jul 03; 5(192):192ra86. PMID: 23825302.
      Citations: 49     Fields:    Translation:HumansCells
    85. Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL, Lander ES, Schaffner SF, Sabeti PC. Identifying recent adaptations in large-scale genomic data. Cell. 2013 Feb 14; 152(4):703-13. PMID: 23415221.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    86. Larson G, Karlsson EK, Perri A, Webster MT, Ho SY, Peters J, Stahl PW, Piper PJ, Lingaas F, Fredholm M, Comstock KE, Modiano JF, Schelling C, Agoulnik AI, Leegwater PA, Dobney K, Vigne JD, Vil? C, Andersson L, Lindblad-Toh K. Rethinking dog domestication by integrating genetics, archeology, and biogeography. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):8878-83. PMID: 22615366.
      Citations: 128     Fields:    Translation:Animals
    87. Vaysse A, Ratnakumar A, Derrien T, Axelsson E, Rosengren Pielberg G, Sigurdsson S, Fall T, Sepp?l? EH, Hansen MS, Lawley CT, Karlsson EK, Bannasch D, Vil? C, Lohi H, Galibert F, Fredholm M, H?ggstr?m J, Hedhammar A, Andr? C, Lindblad-Toh K, Hitte C, Webster MT. Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet. 2011 Oct; 7(10):e1002316. PMID: 22022279.
      Citations: 204     Fields:    Translation:Animals
    88. Sepp?l? EH, Jokinen TS, Fukata M, Fukata Y, Webster MT, Karlsson EK, Kilpinen SK, Steffen F, Dietschi E, Leeb T, Eklund R, Zhao X, Rilstone JJ, Lindblad-Toh K, Minassian BA, Lohi H. LGI2 truncation causes a remitting focal epilepsy in dogs. PLoS Genet. 2011 Jul; 7(7):e1002194. PMID: 21829378.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    89. Karlsson E, Waltersson MA, Bostner J, P?rez-Tenorio G, Olsson B, Hallbeck AL, St?l O. High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer. 2011 Oct; 50(10):775-87. PMID: 21748818.
      Citations: 33     Fields:    Translation:HumansCells
    90. Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet. 2011 Apr; 7(4):e1001383. PMID: 21533027.
      Citations: 58     Fields:    Translation:Animals
    91. Olsson M, Meadows JR, Truv? K, Rosengren Pielberg G, Puppo F, Mauceli E, Quilez J, Tonomura N, Zanna G, Docampo MJ, Bassols A, Avery AC, Karlsson EK, Thomas A, Kastner DL, Bongcam-Rudloff E, Webster MT, Sanchez A, Hedhammar A, Remmers EF, Andersson L, Ferrer L, Tintle L, Lindblad-Toh K. A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs. PLoS Genet. 2011 Mar; 7(3):e1001332. PMID: 21437276.
      Citations: 64     Fields:    Translation:Animals
    92. Wilbe M, Jokinen P, Truv? K, Seppala EH, Karlsson EK, Biagi T, Hughes A, Bannasch D, Andersson G, Hansson-Hamlin H, Lohi H, Lindblad-Toh K. Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet. 2010 Mar; 42(3):250-4. PMID: 20101241.
      Citations: 64     Fields:    Translation:HumansAnimals
    93. Grossman SR, Shlyakhter I, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC. A composite of multiple signals distinguishes causal variants in regions of positive selection. Science. 2010 Feb 12; 327(5967):883-6. PMID: 20056855.
      Citations: 280     Fields:    Translation:HumansCells
    94. Thomas R, Valli VE, Ellis P, Bell J, Karlsson EK, Cullen J, Lindblad-Toh K, Langford CF, Breen M. Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas. Chromosome Res. 2009; 17(8):987-1000. PMID: 19941159.
      Citations: 5     Fields:    Translation:Animals
    95. Haas BJ, Kamoun S, Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AM, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JI, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Gr?nwald NJ, Horn K, Horner NR, Hu CH, Huitema E, Jeong DH, Jones AM, Jones JD, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, Maclean D, Chibucos MC, McDonald H, McWalters J, Meijer HJ, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinz?n A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJ, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PR, Whisson SC, Judelson HS, Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009 Sep 17; 461(7262):393-8. PMID: 19741609.
      Citations: 609     Fields:    Translation:HumansAnimalsCells
    96. Dr?gem?ller C, Karlsson EK, Hyt?nen MK, Perloski M, Dolf G, Sainio K, Lohi H, Lindblad-Toh K, Leeb T. A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science. 2008 Sep 12; 321(5895):1462. PMID: 18787161.
      Citations: 78     Fields:    Translation:AnimalsCells
    97. Karlsson EK, Lindblad-Toh K. Leader of the pack: gene mapping in dogs and other model organisms. Nat Rev Genet. 2008 Sep; 9(9):713-25. PMID: 18714291.
      Citations: 131     Fields:    Translation:HumansAnimals
    98. Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NH, Zody MC, Anderson N, Biagi TM, Patterson N, Pielberg GR, Kulbokas EJ, Comstock KE, Keller ET, Mesirov JP, von Euler H, K?mpe O, Hedhammar A, Lander ES, Andersson G, Andersson L, Lindblad-Toh K. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet. 2007 Nov; 39(11):1321-8. PMID: 17906626.
      Citations: 269     Fields:    Translation:AnimalsCells
    99. Salmon Hillbertz NH, Isaksson M, Karlsson EK, Hellm?n E, Pielberg GR, Savolainen P, Wade CM, von Euler H, Gustafson U, Hedhammar A, Nilsson M, Lindblad-Toh K, Andersson L, Andersson G. Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet. 2007 Nov; 39(11):1318-20. PMID: 17906623.
      Citations: 93     Fields:    Translation:Animals
    100. Thomas R, Duke SE, Bloom SK, Breen TE, Young AC, Feiste E, Seiser EL, Tsai PC, Langford CF, Ellis P, Karlsson EK, Lindblad-Toh K, Breen M. A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog. J Hered. 2007; 98(5):474-84. PMID: 17702974.
      Citations: 19     Fields:    Translation:AnimalsCells
    101. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abebe A, Abouelleil A, Aftuck L, Ait-Zahra M, Aldredge T, Allen N, An P, Anderson S, Antoine C, Arachchi H, Aslam A, Ayotte L, Bachantsang P, Barry A, Bayul T, Benamara M, Berlin A, Bessette D, Blitshteyn B, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Brown A, Cahill P, Calixte N, Camarata J, Cheshatsang Y, Chu J, Citroen M, Collymore A, Cooke P, Dawoe T, Daza R, Decktor K, DeGray S, Dhargay N, Dooley K, Dooley K, Dorje P, Dorjee K, Dorris L, Duffey N, Dupes A, Egbiremolen O, Elong R, Falk J, Farina A, Faro S, Ferguson D, Ferreira P, Fisher S, FitzGerald M, Foley K, Foley C, Franke A, Friedrich D, Gage D, Garber M, Gearin G, Giannoukos G, Goode T, Goyette A, Graham J, Grandbois E, Gyaltsen K, Hafez N, Hagopian D, Hagos B, Hall J, Healy C, Hegarty R, Honan T, Horn A, Houde N, Hughes L, Hunnicutt L, Husby M, Jester B, Jones C, Kamat A, Kanga B, Kells C, Khazanovich D, Kieu AC, Kisner P, Kumar M, Lance K, Landers T, Lara M, Lee W, Leger JP, Lennon N, Leuper L, LeVine S, Liu J, Liu X, Lokyitsang Y, Lokyitsang T, Lui A, Macdonald J, Major J, Marabella R, Maru K, Matthews C, McDonough S, Mehta T, Meldrim J, Melnikov A, Meneus L, Mihalev A, Mihova T, Miller K, Mittelman R, Mlenga V, Mulrain L, Munson G, Navidi A, Naylor J, Nguyen T, Nguyen N, Nguyen C, Nguyen T, Nicol R, Norbu N, Norbu C, Novod N, Nyima T, Olandt P, O'Neill B, O'Neill K, Osman S, Oyono L, Patti C, Perrin D, Phunkhang P, Pierre F, Priest M, Rachupka A, Raghuraman S, Rameau R, Ray V, Raymond C, Rege F, Rise C, Rogers J, Rogov P, Sahalie J, Settipalli S, Sharpe T, Shea T, Sheehan M, Sherpa N, Shi J, Shih D, Sloan J, Smith C, Sparrow T, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Stone S, Sykes S, Tchuinga P, Tenzing P, Tesfaye S, Thoulutsang D, Thoulutsang Y, Topham K, Topping I, Tsamla T, Vassiliev H, Venkataraman V, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Yang S, Yang X, Young G, Yu Q, Zainoun J, Zembek L, Zimmer A, Lander ES. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature. 2005 Dec 08; 438(7069):803-19. PMID: 16341006.
      Citations: 1106     Fields:    Translation:HumansAnimalsCells
    102. Thomas R, Scott A, Langford CF, Fosmire SP, Jubala CM, Lorentzen TD, Hitte C, Karlsson EK, Kirkness E, Ostrander EA, Galibert F, Lindblad-Toh K, Modiano JF, Breen M. Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res. 2005 Dec; 15(12):1831-7. PMID: 16339382.
      Citations: 26     Fields:    Translation:AnimalsCells
    103. Vinson JP, Jaffe DB, O'Neill K, Karlsson EK, Stange-Thomann N, Anderson S, Mesirov JP, Satoh N, Satou Y, Nusbaum C, Birren B, Galagan JE, Lander ES. Assembly of polymorphic genomes: algorithms and application to Ciona savignyi. Genome Res. 2005 Aug; 15(8):1127-35. PMID: 16077012.
      Citations: 85     Fields:    Translation:AnimalsCells
    104. Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ, Gingeras TR, Schreiber SL, Lander ES. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell. 2005 Jan 28; 120(2):169-81. PMID: 15680324.
      Citations: 746     Fields:    Translation:HumansAnimalsCells
    105. O'Lone R, Frith MC, Karlsson EK, Hansen U. Genomic targets of nuclear estrogen receptors. Mol Endocrinol. 2004 Aug; 18(8):1859-75. PMID: 15031323.
      Citations: 164     Fields:    Translation:HumansAnimalsCells
    106. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guig? R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES. Initial sequencing and comparative analysis of the mouse genome. Nature. 2002 Dec 05; 420(6915):520-62. PMID: 12466850.
      Citations: 2906     Fields:    Translation:HumansAnimalsCells
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