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Roberto Bomprezzi MD, PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-3008
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse education and training
    Sapienza University of Rome, Rome, RM, ItalyMD
    Sapienza University of Rome, Rome, RM, ItalyPHDExperimental Neurobiology

    Collapse Overview 
    Collapse Summary
    Dr. Bomprezzi is fellowship trained in neuroimmunology and he is involved in the treatment of inflammatory disorders of the central nervous system, such as multiple sclerosis, neuromyelitis optica, neurosarcoidosis.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bomprezzi R, Chen AP, Hemond CC. Cervical spondylosis is a risk factor for localized spinal cord lesions in multiple sclerosis. Clin Neurol Neurosurg. 2020 Oct 15; 199:106311. PMID: 33091657.
      View in: PubMed
    2. Zhovtis Ryerson L, Frohman TC, Foley J, Kister I, Weinstock-Guttman B, Tornatore C, Pandey K, Donnelly S, Pawate S, Bomprezzi R, Smith D, Kolb C, Qureshi S, Okuda D, Kalina J, Rimler Z, Green R, Monson N, Hoyt T, Bradshaw M, Fallon J, Chamot E, Bucello M, Beh S, Cutter G, Major E, Herbert J, Frohman EM. Extended interval dosing of natalizumab in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016 Aug; 87(8):885-9. PMID: 26917698.
      View in: PubMed
    3. Bomprezzi R. Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview. Ther Adv Neurol Disord. 2015 Jan; 8(1):20-30. PMID: 25584071.
      View in: PubMed
    4. Bomprezzi R, Pawate S. Extended interval dosing of natalizumab: a two-center, 7-year experience. Ther Adv Neurol Disord. 2014 Sep; 7(5):227-31. PMID: 25342976.
      View in: PubMed
    5. Alderazi YJ, Bomprezzi R. Are randomized, blind clinical trials enough to guide individualized decisions for patients with neurologic diseases? Neurol Clin Pract. 2014 Aug; 4(4):319-328. PMID: 29473563.
      View in: PubMed
    6. Howard LG, Bomprezzi R. Demyelinating disease and psoriasis: interferon versus dimethyl fumarate. J Neurol Sci. 2014 Aug 15; 343(1-2):230-1. PMID: 24906711.
      View in: PubMed
    7. Sun F, Ladha SS, Yang L, Liu Q, Shi SX, Su N, Bomprezzi R, Shi FD. Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis. Muscle Nerve. 2014 Apr; 49(4):487-94. PMID: 23868194.
      View in: PubMed
    8. Burgos KL, Javaherian A, Bomprezzi R, Ghaffari L, Rhodes S, Courtright A, Tembe W, Kim S, Metpally R, Van Keuren-Jensen K. Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing. RNA. 2013 May; 19(5):712-22. PMID: 23525801.
      View in: PubMed
    9. Gan Y, Liu R, Wu W, Bomprezzi R, Shi FD. Antibody to a4 integrin suppresses natural killer cells infiltration in central nervous system in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2012 Jun 15; 247(1-2):9-15. PMID: 22503411.
      View in: PubMed
    10. Bomprezzi R, Okuda DT, Alderazi YJ, Stüve O, Frohman EM. From injection therapies to natalizumab: views on the treatment of multiple sclerosis. Ther Adv Neurol Disord. 2012 Mar; 5(2):97-104. PMID: 22435074.
      View in: PubMed
    11. Bomprezzi R, Schafer R, Reese V, Misra A, Vollmer TL, Kala M. Glatiramer acetate-specific antibody titres in patients with relapsing?/?remitting multiple sclerosis and in experimental autoimmune encephalomyelitis. Scand J Immunol. 2011 Sep; 74(3):219-26. PMID: 21615449.
      View in: PubMed
    12. Bomprezzi R, Powers JM, Shimizu J, Tsuji S, Weinshenker BG, Wingerchuk DM. IFNß-1b may severely exacerbate Japanese opticspinal MS in neuromyelitis optica spectrum: Japanese optic-spinal MS: is it MS or neuromyelitis optica and does the answer dictate treatment? Neurology. 2011 Jul 12; 77(2):195; discussion 195-6. PMID: 21747078.
      View in: PubMed
    13. Chansakul C, Moguel-Cobos G, Bomprezzi R. Head tremor secondary to MS resolved with rituximab. Neurol Sci. 2011 Dec; 32(6):1157-60. PMID: 21556869.
      View in: PubMed
    14. Bomprezzi R, Postevka E, Campagnolo D, Vollmer TL. A review of cases of neuromyelitis optica. Neurologist. 2011 Mar; 17(2):98-104. PMID: 21364364.
      View in: PubMed
    15. Chang J, Campagnolo D, Vollmer TL, Bomprezzi R. Demyelinating disease and polyvalent human papilloma virus vaccination. J Neurol Neurosurg Psychiatry. 2011 Nov; 82(11):1296-8. PMID: 20935322.
      View in: PubMed
    16. Bomprezzi R, Pati S, Chansakul C, Vollmer T. A case of neurosarcoidosis successfully treated with rituximab. Neurology. 2010 Aug 10; 75(6):568-70. PMID: 20697110.
      View in: PubMed
    17. Bomprezzi R, Wildemann B. Acute disseminated encephalomyelitis following vaccination against human papilloma virus. Neurology. 2010 Mar 9; 74(10):864; author reply 864-5. PMID: 20211914.
      View in: PubMed
    18. Chansakul C, Teleb M, Bomprezzi R. Palmocervical reflex: a hyperactive palmomental reflex? Neurology. 2010 Jan 5; 74(1):91. PMID: 20038780.
      View in: PubMed
    19. Annibali V, Di Giovanni S, Cannoni S, Giugni E, Bomprezzi R, Mattei C, Elkahloun A, Coccia EM, Alfò M, Orzi F, Ristori G, Salvetti M. Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis. Autoimmunity. 2007 Feb; 40(1):16-22. PMID: 17364493.
      View in: PubMed
    20. Pulciani S, Di Lonardo A, Fagnani C, D'Ippolito C, Bomprezzi R, Stazi MA. [DNA-microarray: new technological approaches on twin studies]. Ann Ist Super Sanita. 2006; 42(2):211-21. PMID: 17033143.
      View in: PubMed
    21. Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfò M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figà Talamanca L, Nisticò L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M. Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study. Ann Neurol. 2006 Jan; 59(1):27-34. PMID: 16240370.
      View in: PubMed
    22. Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, Momigliano-Richiardi P. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 2003 Oct; 143(1-2):97-100. PMID: 14575923.
      View in: PubMed
    23. Bomprezzi R, Kovanen PE, Martin R. New approaches to investigating heterogeneity in complex traits. J Med Genet. 2003 Aug; 40(8):553-9. PMID: 12920061.
      View in: PubMed
    24. Bomprezzi R, Ringnér M, Kim S, Bittner ML, Khan J, Chen Y, Elkahloun A, Yu A, Bielekova B, Meltzer PS, Martin R, McFarland HF, Trent JM. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum Mol Genet. 2003 Sep 1; 12(17):2191-9. PMID: 12915464.
      View in: PubMed
    25. Mellai M, Giordano M, D'Alfonso S, Marchini M, Scorza R, Giovanna Danieli M, Leone M, Ferro I, Liguori M, Trojano M, Ballerini C, Massacesi L, Cannoni S, Bomprezzi R, Momigliano-Richiardi P. Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. Hum Immunol. 2003 Feb; 64(2):274-84. PMID: 12559630.
      View in: PubMed
    26. Salvetti M, Ristori G, Bomprezzi R, Pozzilli P, Leslie RD. Twins: mirrors of the immune system. Immunol Today. 2000 Jul; 21(7):342-7. PMID: 10871876.
      View in: PubMed
    27. D'Alfonso S, Nisticò L, Bocchio D, Bomprezzi R, Marrosu MG, Murru MR, Lai M, Massacesi L, Ballerini C, Repice A, Salvetti M, Montesperelli C, Ristori G, Trojano M, Liguori M, Gambi D, Quattrone A, Tosi R, Momigliano-Richiardi P. An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population. J Neurovirol. 2000 May; 6 Suppl 2:S18-22. PMID: 10871779.
      View in: PubMed
    28. Ristori G, Montesperelli C, Uccelli A, Giunti D, Buttinelli C, Bomprezzi R, Mancardi GL, Salvetti M. A major influence of the T cell receptor repertoire as compared to antigen processing-presentation in the selection of myelin basic protein epitopes in multiple sclerosis. J Neuroimmunol. 1999 May 3; 96(2):241-4. PMID: 10337923.
      View in: PubMed
    29. D'Alfonso S, Nisticò L, Zavattari P, Marrosu MG, Murru R, Lai M, Massacesi L, Ballerini C, Gestri D, Salvetti M, Ristori G, Bomprezzi R, Trojano M, Liguori M, Gambi D, Quattrone A, Fruci D, Cucca F, Richiardi PM, Tosi R. Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families. Eur J Hum Genet. 1999 Apr; 7(3):377-85. PMID: 10234515.
      View in: PubMed
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