Multiple Sclerosis

"Multiple Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Descriptor ID	D009103
MeSH Number(s)	C10.114.375.500 C10.314.350.500 C20.111.258.250.500
Concept/Terms	Multiple Sclerosis Multiple Sclerosis Sclerosis, Multiple Sclerosis, Disseminated Disseminated Sclerosis MS (Multiple Sclerosis) Multiple Sclerosis, Acute Fulminating Multiple Sclerosis, Acute Fulminating

Below are MeSH descriptors whose meaning is more general than "Multiple Sclerosis".

Diseases [C]
Nervous System Diseases [C10]
Autoimmune Diseases of the Nervous System [C10.114]
Demyelinating Autoimmune Diseases, CNS [C10.114.375]
Multiple Sclerosis [C10.114.375.500]
Demyelinating Diseases [C10.314]
Demyelinating Autoimmune Diseases, CNS [C10.314.350]
Multiple Sclerosis [C10.314.350.500]
Immune System Diseases [C20]
Autoimmune Diseases [C20.111]
Autoimmune Diseases of the Nervous System [C20.111.258]
Demyelinating Autoimmune Diseases, CNS [C20.111.258.250]
Multiple Sclerosis [C20.111.258.250.500]

Below are MeSH descriptors whose meaning is related to "Multiple Sclerosis".

Below are MeSH descriptors whose meaning is more specific than "Multiple Sclerosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Multiple Sclerosis" by people in this website by year, and whether "Multiple Sclerosis" was a major or minor topic of these publications.

Bar chart showing 172 publications over 31 distinct years, with a maximum of 14 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	3	0	3
1998	2	0	2
1999	3	0	3
2000	2	0	2
2001	1	0	1
2002	0	1	1
2003	6	0	6
2004	1	0	1
2005	5	0	5
2006	3	0	3
2007	5	1	6
2008	3	0	3
2009	4	2	6
2010	1	1	2
2011	4	4	8
2012	4	1	5
2013	7	1	8
2014	8	2	10
2015	7	0	7
2016	7	0	7
2017	2	0	2
2018	5	1	6
2019	9	2	11
2020	8	2	10
2021	10	1	11
2022	11	1	12
2023	9	0	9
2024	13	1	14
2025	3	1	4
2026	3	0	3

Below are the most recent publications written about "Multiple Sclerosis" by people in Profiles.

Corazzolla G, Treaba CA, Mohammadian M, Brusaferri L, Barletta VT, Z?rcher NR, Hooker JM, Sloane JA, Klawiter EC, Bomprezzi R, Rocca MA, Filippi M, Loggia ML, Mainero C. Evidence of skull bone translocator protein overexpression linked to multiple sclerosis progression. Brain. 2026 Jun 03; 149(6):2032-2045.

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Benveniste PL, L?tourneau-Guillon L, Araujo D, Chougar L, Fetco D, Hori M, Kamiya K, Messina S, Tsagkas C, Audoin B, Bakshi R, Bannier E, Blezek D, Brisset JC, Callot V, Charlson E, Chen M, Ciccarelli O, Demorti?re S, Edan G, Filippi M, Granberg T, Granziera C, Hemond CC, Keegan BM, Kerbrat A, Kirschke J, Kolind S, Labauge P, Lee LE, Liu Y, Mainero C, McGinnis J, Laines Medina N, M?hlau M, Nair G, O'Grady KP, Oh J, Ouellette R, Prat A, Reich DS, Rocca MA, Shepherd TM, Smith SA, Stawiarz L, Talbott J, Tam R, Tauhid S, Traboulsee A, Treaba CA, Valsasina P, Vavasour Z, Yiannakas M, Lombaert H, Cohen-Adad J. Generalizable spinal cord multiple sclerosis lesion segmentation across MRI contrasts, protocols, and centers. Mult Scler. 2026 May; 32(6):598-613.

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Peltz-Rauchman CD, Meng Z, Ma L, Yeh HH, Joseph CL, Chesla D, Epstein M, Garber L, Stevens A, Waring SC, Ziegenfuss J, Cerghet M, Ahmedani B, Johnson CC. Multiple sclerosis in the All of Us Research Program: Prevalence and associated demographic and geographic characteristics. Mult Scler Relat Disord. 2026 May; 109:107126.

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Kwon S, Han KD, Jung JH, Cho EB, Park J, Eun Y, Kim H, Chung YH, Shin DW, Min JH. Risk of Autoimmune Rheumatic Diseases in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Nationwide Cohort Study in South Korea. Mayo Clin Proc. 2025 May; 100(5):801-813.

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Gross PS, Dur?n-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.

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Lin JP, Brake A, Donadieu M, Lee A, Smith G, Hu K, Nair G, Kawaguchi R, Sati P, Geschwind DH, Jacobson S, Schafer DP, Reich DS. 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. Science. 2025 02 28; 387(6737):eadp6325.

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Al Gburi M, Mazzola M, Absinta M, Gait?n MI, Reich DS, Dundamadappa SK, Hemond CC. Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter. Mult Scler. 2025 Mar; 31(3):263-277.

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Treaba CA, Herranz E, Barletta VT, Mehndiratta A, Sloane JA, Granberg T, Miscioscia A, Bomprezzi R, Loggia ML, Mainero C. Phenotyping in vivo chronic inflammation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7T susceptibility-weighted imaging. Mult Scler. 2024 Dec; 30(14):1755-1764.

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Rabin A, Bello E, Kumar S, Zeki DA, Afshari K, Deshpande M, Francis N, Khalighinejad F, Umeton R, Radu I, Qutab F, Kwong D, Kurban M, Hemond C, Richmond JM, Ionete C. Targeted proteomics of cerebrospinal fluid in treatment na?ve multiple sclerosis patients identifies immune biomarkers of clinical phenotypes. Sci Rep. 2024 09 18; 14(1):21793.

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Bagnato F, Sati P, Hemond CC, Elliott C, Gauthier SA, Harrison DM, Mainero C, Oh J, Pitt D, Shinohara RT, Smith SA, Trapp B, Azevedo CJ, Calabresi PA, Henry RG, Laule C, Ontaneda D, Rooney WD, Sicotte NL, Reich DS, Absinta M. Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain. 2024 Sep 03; 147(9):2913-2933.

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