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Roberto Bomprezzi MD, PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    InstitutionT.H. Chan School of Medicine

    Collapse Biography 
    Collapse education and training
    Sapienza University of Rome, Rome, RM, ItalyMD
    Sapienza University of Rome, Rome, RM, ItalyPHDExperimental Neurobiology

    Collapse Overview 
    Collapse Summary
    Dr. Bomprezzi is fellowship trained in neuroimmunology and he is involved in the treatment of inflammatory disorders of the central nervous system, such as multiple sclerosis, neuromyelitis optica, neurosarcoidosis.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bomprezzi R, Chen AP, Hemond CC. Cervical spondylosis is a risk factor for localized spinal cord lesions in multiple sclerosis. Clin Neurol Neurosurg. 2020 12; 199:106311. PMID: 33091657.
      Citations: 1     Fields:    Translation:Humans
    2. Zhovtis Ryerson L, Frohman TC, Foley J, Kister I, Weinstock-Guttman B, Tornatore C, Pandey K, Donnelly S, Pawate S, Bomprezzi R, Smith D, Kolb C, Qureshi S, Okuda D, Kalina J, Rimler Z, Green R, Monson N, Hoyt T, Bradshaw M, Fallon J, Chamot E, Bucello M, Beh S, Cutter G, Major E, Herbert J, Frohman EM. Extended interval dosing of natalizumab in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016 Aug; 87(8):885-9. PMID: 26917698.
      Citations: 51     Fields:    Translation:Humans
    3. Bomprezzi R. Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview. Ther Adv Neurol Disord. 2015 Jan; 8(1):20-30. PMID: 25584071.
    4. Bomprezzi R, Pawate S. Extended interval dosing of natalizumab: a two-center, 7-year experience. Ther Adv Neurol Disord. 2014 Sep; 7(5):227-31. PMID: 25342976.
    5. Alderazi YJ, Bomprezzi R. Are randomized, blind clinical trials enough to guide individualized decisions for patients with neurologic diseases? Neurol Clin Pract. 2014 Aug; 4(4):319-328. PMID: 29473563.
    6. Howard LG, Bomprezzi R. Demyelinating disease and psoriasis: interferon versus dimethyl fumarate. J Neurol Sci. 2014 Aug 15; 343(1-2):230-1. PMID: 24906711.
      Citations: 1     Fields:    Translation:Humans
    7. Sun F, Ladha SS, Yang L, Liu Q, Shi SX, Su N, Bomprezzi R, Shi FD. Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis. Muscle Nerve. 2014 Apr; 49(4):487-94. PMID: 23868194.
      Citations: 36     Fields:    Translation:HumansCells
    8. Burgos KL, Javaherian A, Bomprezzi R, Ghaffari L, Rhodes S, Courtright A, Tembe W, Kim S, Metpally R, Van Keuren-Jensen K. Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing. RNA. 2013 May; 19(5):712-22. PMID: 23525801.
      Citations: 114     Fields:    Translation:HumansAnimals
    9. Gan Y, Liu R, Wu W, Bomprezzi R, Shi FD. Antibody to a4 integrin suppresses natural killer cells infiltration in central nervous system in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2012 Jun 15; 247(1-2):9-15. PMID: 22503411.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Bomprezzi R, Okuda DT, Alderazi YJ, St?ve O, Frohman EM. From injection therapies to natalizumab: views on the treatment of multiple sclerosis. Ther Adv Neurol Disord. 2012 Mar; 5(2):97-104. PMID: 22435074.
    11. Bomprezzi R, Schaefer R, Reese V, Misra A, Vollmer TL, Kala M. Glatiramer acetate-specific antibody titres in patients with relapsing?/?remitting multiple sclerosis and in experimental autoimmune encephalomyelitis. Scand J Immunol. 2011 Sep; 74(3):219-226. PMID: 21615449.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Bomprezzi R, Powers JM, Shimizu J, Tsuji S, Weinshenker BG, Wingerchuk DM. IFN?-1b may severely exacerbate Japanese opticspinal MS in neuromyelitis optica spectrum: Japanese optic-spinal MS: is it MS or neuromyelitis optica and does the answer dictate treatment? Neurology. 2011 Jul 12; 77(2):195; discussion 195-6. PMID: 21747078.
      Citations: 2     Fields:    Translation:Humans
    13. Chansakul C, Moguel-Cobos G, Bomprezzi R. Head tremor secondary to MS resolved with rituximab. Neurol Sci. 2011 Dec; 32(6):1157-60. PMID: 21556869.
      Citations: 2     Fields:    Translation:Humans
    14. Bomprezzi R, Postevka E, Campagnolo D, Vollmer TL. A review of cases of neuromyelitis optica. Neurologist. 2011 Mar; 17(2):98-104. PMID: 21364364.
      Citations: 4     Fields:    Translation:HumansCells
    15. Chang J, Campagnolo D, Vollmer TL, Bomprezzi R. Demyelinating disease and polyvalent human papilloma virus vaccination. J Neurol Neurosurg Psychiatry. 2011 Nov; 82(11):1296-8. PMID: 20935322.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    16. Bomprezzi R, Pati S, Chansakul C, Vollmer T. A case of neurosarcoidosis successfully treated with rituximab. Neurology. 2010 Aug 10; 75(6):568-70. PMID: 20697110.
      Citations: 23     Fields:    Translation:Humans
    17. Bomprezzi R, Wildemann B. Acute disseminated encephalomyelitis following vaccination against human papilloma virus. Neurology. 2010 Mar 09; 74(10):864; author reply 864-5. PMID: 20211914.
      Citations: 2     Fields:    Translation:Humans
    18. Chansakul C, Teleb M, Bomprezzi R. Palmocervical reflex: a hyperactive palmomental reflex? Neurology. 2010 Jan 05; 74(1):91. PMID: 20038780.
      Citations:    Fields:    Translation:Humans
    19. Annibali V, Di Giovanni S, Cannoni S, Giugni E, Bomprezzi R, Mattei C, Elkahloun A, Coccia EM, Alf? M, Orzi F, Ristori G, Salvetti M. Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis. Autoimmunity. 2007 Feb; 40(1):16-22. PMID: 17364493.
      Citations: 5     Fields:    Translation:HumansCells
    20. Pulciani S, Di Lonardo A, Fagnani C, D'Ippolito C, Bomprezzi R, Stazi MA. [DNA-microarray: new technological approaches on twin studies]. Ann Ist Super Sanita. 2006; 42(2):211-21. PMID: 17033143.
      Citations:    Fields:    Translation:Humans
    21. Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alf? M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Fig? Talamanca L, Nistic? L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M. Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study. Ann Neurol. 2006 Jan; 59(1):27-34. PMID: 16240370.
      Citations: 25     Fields:    Translation:Humans
    22. Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, Momigliano-Richiardi P. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 2003 Oct; 143(1-2):97-100. PMID: 14575923.
      Citations: 3     Fields:    Translation:HumansCells
    23. Bomprezzi R, Kovanen PE, Martin R. New approaches to investigating heterogeneity in complex traits. J Med Genet. 2003 Aug; 40(8):553-9. PMID: 12920061.
      Citations: 9     Fields:    Translation:HumansCells
    24. Bomprezzi R, Ringn?r M, Kim S, Bittner ML, Khan J, Chen Y, Elkahloun A, Yu A, Bielekova B, Meltzer PS, Martin R, McFarland HF, Trent JM. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum Mol Genet. 2003 Sep 01; 12(17):2191-9. PMID: 12915464.
      Citations: 65     Fields:    Translation:HumansCells
    25. Mellai M, Giordano M, D'Alfonso S, Marchini M, Scorza R, Danieli M.G., Leone M, Ferro I, Liguori M, Trojano M, Ballerini C, Massacesi L, Cannoni S, Bomprezzi R, Momigliano-Richiardi P. Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. Hum Immunol. 2003 02; 64(2):274-84. PMID: 12559630.
      Citations: 7     Fields:    Translation:HumansCells
    26. Salvetti M, Ristori G, Bomprezzi R, Pozzilli P, Leslie RD. Twins: mirrors of the immune system. Immunol Today. 2000 Jul; 21(7):342-7. PMID: 10871876.
      Citations: 18     Fields:    Translation:Humans
    27. D'Alfonso S, Nistic? L, Bocchio D, Bomprezzi R, Marrosu MG, Murru MR, Lai M, Massacesi L, Ballerini C, Repice A, Salvetti M, Montesperelli C, Ristori G, Trojano M, Liguori M, Gambi D, Quattrone A, Tosi R, Momigliano-Richiardi P. An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population. J Neurovirol. 2000 May; 6 Suppl 2:S18-22. PMID: 10871779.
      Citations: 1     Fields:    Translation:HumansCells
    28. Ristori G, Montesperelli C, Uccelli A, Giunti D, Buttinelli C, Bomprezzi R, Mancardi GL, Salvetti M. A major influence of the T cell receptor repertoire as compared to antigen processing-presentation in the selection of myelin basic protein epitopes in multiple sclerosis. J Neuroimmunol. 1999 May 03; 96(2):241-4. PMID: 10337923.
      Citations:    Fields:    Translation:HumansCells
    29. D'Alfonso S, Nistic? L, Zavattari P, Marrosu MG, Murru R, Lai M, Massacesi L, Ballerini C, Gestri D, Salvetti M, Ristori G, Bomprezzi R, Trojano M, Liguori M, Gambi D, Quattrone A, Fruci D, Cucca F, Richiardi PM, Tosi R. Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families. Eur J Hum Genet. 1999 Apr; 7(3):377-85. PMID: 10234515.
      Citations: 5     Fields:    Translation:Humans
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