Arachidonate 5-Lipoxygenase

"Arachidonate 5-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.

Descriptor ID	D001094
MeSH Number(s)	D08.811.682.690.416.583.500.055 D12.776.556.579.374.568.500.020
Concept/Terms	Arachidonate 5-Lipoxygenase Arachidonate 5-Lipoxygenase 5-Lipoxygenase, Arachidonate Arachidonate 5 Lipoxygenase Arachidonic Acid 5-Lipoxygenase 5-Lipoxygenase, Arachidonic Acid Arachidonic Acid 5 Lipoxygenase LTA4 Synthase Synthase, LTA4 Leukotriene A4 Synthase Synthase, Leukotriene A4 Leukotriene A4 Synthetase Synthetase, Leukotriene A4 5-Lipoxygenase 5 Lipoxygenase Leukotriene A Synthase Synthase, Leukotriene A

Below are MeSH descriptors whose meaning is more general than "Arachidonate 5-Lipoxygenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Dioxygenases [D08.811.682.690.416]
Lipoxygenases [D08.811.682.690.416.583]
Arachidonate Lipoxygenases [D08.811.682.690.416.583.500]
Arachidonate 5-Lipoxygenase [D08.811.682.690.416.583.500.055]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Lipoxygenases [D12.776.556.579.374.568]
Arachidonate Lipoxygenases [D12.776.556.579.374.568.500]
Arachidonate 5-Lipoxygenase [D12.776.556.579.374.568.500.020]

Below are MeSH descriptors whose meaning is related to "Arachidonate 5-Lipoxygenase".

Below are MeSH descriptors whose meaning is more specific than "Arachidonate 5-Lipoxygenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 2003 and 2006 and 2009 and 2010 and 2011 and 2012 and 2014 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2006	1	0	1
2009	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	1	1
2014	1	0	1
2016	1	0	1

Below are the most recent publications written about "Arachidonate 5-Lipoxygenase" by people in Profiles.

Walker ME, Matthan NR, Goldbaum A, Meng H, Lamon-Fava S, Lakshman S, Jang S, Molokin A, Solano-Aguilar G, Urban JF, Lichtenstein AH. Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig. J Nutr Biochem. 2019 08; 70:138-146.

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Chen Y, Shan Y, Lu M, DeSouza N, Guo Z, Hoffman R, Liang A, Li S. Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice. Cancer Res. 2017 01 01; 77(1):164-174.

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Landgraf SS, Silva LS, Peruchetti DB, Sirtoli GM, Moraes-Santos F, Portella VG, Silva-Filho JL, Pinheiro CS, Abreu TP, Takiya CM, Benjamin CF, Pinheiro AA, Canetti C, Caruso-Neves C. 5-Lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS One. 2014; 9(10):e107549.

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Peng C, Chen Y, Shan Y, Zhang H, Guo Z, Li D, Li S. LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells. PLoS One. 2012; 7(6):e38614.

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Chen Y, Sullivan C, Peng C, Shan Y, Hu Y, Li D, Li S. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood. 2011 Jul 14; 118(2):390-400.

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Divangahi M, Desjardins D, Nunes-Alves C, Remold HG, Behar SM. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol. 2010 Aug; 11(8):751-8.

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Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9.

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Kalayci O, Birben E, Sackesen C, Keskin O, Tahan F, Wechsler ME, Civelek E, Soyer OU, Adalioglu G, Tuncer A, Israel E, Lilly C. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. Allergy. 2006 Jan; 61(1):97-103.

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Song Y, Jones JE, Beppu H, Keaney JF, Loscalzo J, Zhang YY. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation. 2005 Jul 26; 112(4):553-62.

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Kalayci O, Wechsler M, Galper B, Hong C, Israel E, Drazen JM, Lilly CM. LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. Adv Exp Med Biol. 2003; 525:11-4.

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