"Aphidicolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
| Descriptor ID |
D016590
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| MeSH Number(s) |
D02.455.849.291.075
|
| Concept/Terms |
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer- Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
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Below are MeSH descriptors whose meaning is more general than "Aphidicolin".
Below are MeSH descriptors whose meaning is more specific than "Aphidicolin".
This graph shows the total number of publications written about "Aphidicolin" by people in this website by year, and whether "Aphidicolin" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aphidicolin" by people in Profiles.
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Galindo M, Kahler RA, Teplyuk NM, Stein JL, Lian JB, Stein GS, Westendorf JJ, van Wijnen AJ. Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts. J Mol Histol. 2007 Oct; 38(5):501-6.
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Serhan F, Penaud M, Petit C, Leste-Lasserre T, Trajcevski S, Klatzmann D, Duisit G, Sonigo P, Moullier P. Early detection of a two-long-terminal-repeat junction molecule in the cytoplasm of recombinant murine leukemia virus-infected cells. J Virol. 2004 Jun; 78(12):6190-9.
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Wiedemeier AM, Judy-March JE, Hocart CH, Wasteneys GO, Williamson RE, Baskin TI. Mutant alleles of Arabidopsis RADIALLY SWOLLEN 4 and 7 reduce growth anisotropy without altering the transverse orientation of cortical microtubules or cellulose microfibrils. Development. 2002 Oct; 129(20):4821-30.
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Sibon OC, Kelkar A, Lemstra W, Theurkauf WE. DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos. Nat Cell Biol. 2000 Feb; 2(2):90-5.
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Hinchcliffe EH, Thompson EA, Miller FJ, Yang J, Sluder G. Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote. J Cell Sci. 1999 Apr; 112 ( Pt 8):1139-48.
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Sibon OC, Lauren?on A, Hawley R, Theurkauf WE. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition. Curr Biol. 1999 Mar 25; 9(6):302-12.
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Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science. 1999 Feb 05; 283(5403):851-4.
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Sluder G, Thompson EA, Rieder CL, Miller FJ. Nuclear envelope breakdown is under nuclear not cytoplasmic control in sea urchin zygotes. J Cell Biol. 1995 Jun; 129(6):1447-58.
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Khan NN, Reha-Krantz LJ, Wright GE. Analysis of inhibitors of bacteriophage T4 DNA polymerase. Nucleic Acids Res. 1994 Jan 25; 22(2):232-7.
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Arabshahi L, Brown N, Khan N, Wright G. Inhibition of DNA polymerase alpha by aphidicolin derivatives. Nucleic Acids Res. 1988 Jun 10; 16(11):5107-13.