Colforsin

"Colforsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Descriptor ID	D005576
MeSH Number(s)	D02.455.849.291.300
Concept/Terms	Colforsin Colforsin N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl Coleonol Forskolin NKH 477 NKH 477 NKH-477 NKH477

Below are MeSH descriptors whose meaning is more general than "Colforsin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Hydrocarbons [D02.455]
Terpenes [D02.455.849]
Diterpenes [D02.455.849.291]
Colforsin [D02.455.849.291.300]

Below are MeSH descriptors whose meaning is related to "Colforsin".

Below are MeSH descriptors whose meaning is more specific than "Colforsin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Colforsin" by people in this website by year, and whether "Colforsin" was a major or minor topic of these publications.

Bar chart showing 20 publications over 16 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	1	1
1999	1	0	1
2000	0	1	1
2001	0	1	1
2002	0	2	2
2003	1	2	3
2005	0	1	1
2008	0	2	2
2011	0	1	1
2012	0	1	1
2013	0	1	1
2015	1	0	1
2017	0	1	1
2021	0	1	1
2024	0	1	1

Below are the most recent publications written about "Colforsin" by people in Profiles.

Desai A, Loureiro ZY, DeSouza T, Yang Q, Solivan-Rivera J, Corvera S. cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis. Mol Metab. 2024 Dec; 90:102051.

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Roderick JE, Gallagher KM, Murphy LC, O'Connor KW, Tang K, Zhang B, Brehm MA, Greiner DL, Yu J, Zhu LJ, Green MR, Kelliher MA. Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. 2021 01 28; 137(4):500-512.

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Markussen LK, Isidor MS, Breining P, Andersen ES, Rasmussen NE, Petersen LI, Pedersen SB, Richelsen B, Hansen JB. Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. PLoS One. 2017; 12(9):e0185624.

View in: PubMed
Li K, Zhang H, Qiu J, Lin Y, Liang J, Xiao X, Fu L, Wang F, Cai J, Tan Y, Zhu W, Yin W, Lu B, Xing F, Tang L, Yan M, Mai J, Li Y, Chen W, Qiu P, Su X, Gao G, Tai PW, Hu J, Yan G. Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1. Mol Ther. 2016 Feb; 24(1):156-65.

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Wertheimer E, Krapf D, de la Vega-Beltran JL, S?nchez-C?rdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J, Mager J, Darszon A, Visconti PE. Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. J Biol Chem. 2013 Dec 06; 288(49):35307-20.

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Komatsu S, Dobson JG, Ikebe M, Shea LG, Fenton RA. Crosstalk between adenosine A1 and ?1-adrenergic receptors regulates translocation of PKCe in isolated rat cardiomyocytes. J Cell Physiol. 2012 Sep; 227(9):3201-7.

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Robichaud T, Appleyard AN, Herbert RB, Henderson PJ, Carruthers A. Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial site. Biochemistry. 2011 Apr 19; 50(15):3137-48.

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Huang H, Chikazu D, Voznesensky OS, Herschman HR, Kream BE, Drissi H, Pilbeam CC. Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. J Bone Miner Res. 2010 Apr; 25(4):819-29.

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Hsu PY, Kotin RM, Yang YW. Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes. Pharm Res. 2008 Jun; 25(6):1460-8.

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Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008 Apr; 28(7):2187-200.

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