Diphosphonates

"Diphosphonates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.

Descriptor ID	D004164
MeSH Number(s)	D02.705.429.500
Concept/Terms	Diphosphonates Diphosphonates Bisphosphonates

Below are MeSH descriptors whose meaning is more general than "Diphosphonates".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Organophosphorus Compounds [D02.705]
Organophosphonates [D02.705.429]
Diphosphonates [D02.705.429.500]

Below are MeSH descriptors whose meaning is related to "Diphosphonates".

Below are MeSH descriptors whose meaning is more specific than "Diphosphonates".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Diphosphonates" by people in this website by year, and whether "Diphosphonates" was a major or minor topic of these publications.

Bar chart showing 27 publications over 13 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	1	0	1
2004	1	1	2
2006	0	3	3
2007	1	2	3
2009	2	1	3
2010	3	1	4
2011	0	1	1
2012	1	0	1
2013	1	0	1
2014	0	1	1
2017	2	1	3
2018	1	0	1

Below are the most recent publications written about "Diphosphonates" by people in Profiles.

Jategaonkar AA, Badhey AK, Sokoya M, Kadakia S, Mudrovich S, Ducic Y. Total mandibulectomy defect in the setting of chronic bisphosphonate use. Am J Otolaryngol. 2018 Sep - Oct; 39(5):649-651.

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Kempfle JS, Nguyen K, Hamadani C, Koen N, Edge AS, Kashemirov BA, Jung DH, McKenna CE. Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss. Bioconjug Chem. 2018 04 18; 29(4):1240-1250.

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Kim Y, Zhang Z, Shim JH, Lee TS, Tung CH. A cell surface clicked navigation system to direct specific bone targeting. Bioorg Med Chem. 2018 02 01; 26(3):758-764.

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Vaysbrot EE, Osani MC, Musetti MC, McAlindon TE, Bannuru RR. Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2018 02; 26(2):154-164.

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Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L, Rao M, Robinson AB, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T. 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Rheumatol. 2017 08; 69(8):1521-1537.

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Otero JE, Stevens JW, Malandra AE, Fredericks DC, Odgren PR, Buckwalter JA, Morcuende J. Osteoclast inhibition impairs chondrosarcoma growth and bone destruction. J Orthop Res. 2014 Dec; 32(12):1562-71.

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D?ez-P?rez A, Adachi JD, Adami S, Anderson FA, Boonen S, Chapurlat R, Compston JE, Cooper C, Gehlbach SH, Greenspan SL, Hooven FH, LaCroix AZ, Nieves JW, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Silverman S, Siris ES, Wyman A, Rushton-Smith SK, Watts NB. Risk factors for treatment failure with antiosteoporosis medication: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res. 2014 Jan; 29(1):260-7.

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Lin D, Kramer JR, Ramsey D, Alsarraj A, Verstovsek G, Rugge M, Parente P, Graham DY, El-Serag HB. Oral bisphosphonates and the risk of Barrett's esophagus: case-control analysis of US veterans. Am J Gastroenterol. 2013 Oct; 108(10):1576-83.

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Albadawi H, Haurani MJ, Oklu R, Trubiano JP, Laub PJ, Yoo HJ, Watkins MT. Differential effect of zoledronic acid on human vascular smooth muscle cells. J Surg Res. 2013 Jun 15; 182(2):339-46.

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Schnatz PF, Marakovits KA, Dubois M, O'Sullivan DM. Osteoporosis screening and treatment guidelines: are they being followed? Menopause. 2011 Oct; 18(10):1072-8.

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