Corticotropin-Releasing Hormone

"Corticotropin-Releasing Hormone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

Descriptor ID	D003346
MeSH Number(s)	D06.472.699.327.740.140 D12.644.400.400.740.140 D12.644.548.365.740.140 D12.776.631.650.405.740.140
Concept/Terms	Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone Corticotropin Releasing Hormone Corticoliberin Corticotropin-Releasing Factor Corticotropin Releasing Factor Corticotropin-Releasing Factor-41 Corticotropin Releasing Factor 41 CRF (ACTH) Corticotropin-Releasing Hormone-41 Corticotropin Releasing Hormone 41 CRF-41 ACTH-Releasing Hormone ACTH Releasing Hormone ACTH-Releasing Factor ACTH Releasing Factor

Below are MeSH descriptors whose meaning is more general than "Corticotropin-Releasing Hormone".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Hypothalamic Hormones [D06.472.699.327]
Pituitary Hormone-Releasing Hormones [D06.472.699.327.740]
Corticotropin-Releasing Hormone [D06.472.699.327.740.140]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Neuropeptides [D12.644.400]
Hypothalamic Hormones [D12.644.400.400]
Pituitary Hormone-Releasing Hormones [D12.644.400.400.740]
Corticotropin-Releasing Hormone [D12.644.400.400.740.140]
Peptide Hormones [D12.644.548]
Hypothalamic Hormones [D12.644.548.365]
Pituitary Hormone-Releasing Hormones [D12.644.548.365.740]
Corticotropin-Releasing Hormone [D12.644.548.365.740.140]
Proteins [D12.776]
Nerve Tissue Proteins [D12.776.631]
Neuropeptides [D12.776.631.650]
Hypothalamic Hormones [D12.776.631.650.405]
Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
Corticotropin-Releasing Hormone [D12.776.631.650.405.740.140]

Below are MeSH descriptors whose meaning is related to "Corticotropin-Releasing Hormone".

Below are MeSH descriptors whose meaning is more specific than "Corticotropin-Releasing Hormone".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Corticotropin-Releasing Hormone" by people in this website by year, and whether "Corticotropin-Releasing Hormone" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 3 publications in 2015 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	0	1	1
2007	1	0	1
2008	0	1	1
2009	0	1	1
2012	1	0	1
2014	1	0	1
2015	1	2	3
2016	1	2	3

Below are the most recent publications written about "Corticotropin-Releasing Hormone" by people in Profiles.

Molas S, DeGroot SR, Zhao-Shea R, Tapper AR. Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis. Trends Pharmacol Sci. 2017 02; 38(2):169-180.

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Schreiber AL, Lu YL, Baynes BB, Richardson HN, Gilpin NW. Corticotropin-releasing factor in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context. Neuropharmacology. 2017 02; 113(Pt A):323-330.

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Itoga CA, Roltsch Hellard EA, Whitaker AM, Lu YL, Schreiber AL, Baynes BB, Baiamonte BA, Richardson HN, Gilpin NW. Traumatic Stress Promotes Hyperalgesia via Corticotropin-Releasing Factor-1 Receptor (CRFR1) Signaling in Central Amygdala. Neuropsychopharmacology. 2016 09; 41(10):2463-72.

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Edwards S, Little HJ, Richardson HN, Vendruscolo LF. Divergent regulation of distinct glucocorticoid systems in alcohol dependence. Alcohol. 2015 Dec; 49(8):811-6.

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Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770.

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Logan RW, Wynne O, Maglakelidze G, Zhang C, O'Connell S, Boyadjieva NI, Sarkar DK. ?-Endorphin neuronal transplantation into the hypothalamus alters anxiety-like behaviors in prenatal alcohol-exposed rats and alcohol-non-preferring and alcohol-preferring rats. Alcohol Clin Exp Res. 2015 Jan; 39(1):146-57.

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Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8.

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Gilpin NW, Karanikas CA, Richardson HN. Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats. PLoS One. 2012; 7(2):e31466.

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Witkiewitz K, Holmes A, Ray LA, Murphy JG, Richardson HN, Chen YC, McDevitt-Murphy ME, Cruz MT, Roberto M. Young Investigator Award symposium. Alcohol. 2009 Nov; 43(7):499-508.

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Richardson HN, Lee SY, O'Dell LE, Koob GF, Rivier CL. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci. 2008 Oct; 28(8):1641-53.

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