 Cocaine
"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
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| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.869.388 D04.075.080.875.099.722.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 1 | 0 | 1 | | 1988 | 1 | 0 | 1 | | 1989 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 | | 1991 | 2 | 0 | 2 | | 1992 | 3 | 1 | 4 | | 1993 | 6 | 0 | 6 | | 1994 | 4 | 0 | 4 | | 1995 | 3 | 0 | 3 | | 1996 | 2 | 0 | 2 | | 1997 | 7 | 0 | 7 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 1 | 2 | | 2001 | 2 | 0 | 2 | | 2002 | 3 | 0 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 0 | 3 | | 2006 | 3 | 0 | 3 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 3 | 0 | 3 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 0 | 1 | | 2015 | 2 | 2 | 4 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Carreiro S, Fang H, Zhang J, Wittbold K, Weng S, Mullins R, Smelson D, Boyer EW. iMStrong: Deployment of a Biosensor System to Detect Cocaine Use. J Med Syst. 2015 Dec; 39(12):186.
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You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, David Leonardo E, Bohn LM, Wee S. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology. 2016 Apr; 41(5):1210-22.
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Carreiro S, Smelson D, Ranney M, Horvath KJ, Picard RW, Boudreaux ED, Hayes R, Boyer EW. Real-time mobile detection of drug use with wearable biosensors: a pilot study. J Med Toxicol. 2015 Mar; 11(1):73-9.
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Carreiro S, Hack JB, Blum J. In reply. Ann Emerg Med. 2015 Jan; 65(1):127-8.
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Akyuz N, Kekatpure MV, Liu J, Sheinkopf SJ, Quinn BT, Lala MD, Kennedy D, Makris N, Lester BM, Kosofsky BE. Structural brain imaging in children and adolescents following prenatal cocaine exposure: preliminary longitudinal findings. Dev Neurosci. 2014; 36(3-4):316-28.
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Carreiro S, Blum J, Hack JB. Pretreatment with intravenous lipid emulsion reduces mortality from cocaine toxicity in a rat model. Ann Emerg Med. 2014 Jul; 64(1):32-7.
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Chhabra L, Abraham GM. An unusual oro-naso-sinus communication resulting from heroin and cocaine snorting. BMJ Case Rep. 2013; 2013.
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Hope BT, Skinner MK, Kenny PJ, Akbarian S. Exploring the epigenetics of cocaine resistance. Nat Med. 2013 Feb; 19(2):136-7.
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Smelson D, Chen KW, Ziedonis D, Andes K, Lennox A, Callahan L, Rodrigues S, Eisenberg D. A pilot study of Qigong for reducing cocaine craving early in recovery. J Altern Complement Med. 2013 Feb; 19(2):97-101.
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Calcaterra S, Blatchford P, Friedmann PD, Binswanger IA. Psychostimulant-related deaths among former inmates. J Addict Med. 2012 Jun; 6(2):97-105.
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