Immunoglobulin Heavy Chains

"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Descriptor ID	D007143
MeSH Number(s)	D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
Concept/Terms	Immunoglobulin Heavy Chains Immunoglobulin Heavy Chains Heavy Chains, Immunoglobulin Ig Heavy Chains Heavy Chains, Ig Immunoglobulins, Heavy-Chain Immunoglobulins, Heavy Chain Heavy-Chain Immunoglobulins Heavy Chain Immunoglobulins Immunoglobulin Heavy Chain Heavy Chain, Immunoglobulin Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH III Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH I

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Subunits [D12.776.124.486.485.705]
Immunoglobulin Heavy Chains [D12.776.124.486.485.705.500]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Subunits [D12.776.124.790.651.705]
Immunoglobulin Heavy Chains [D12.776.124.790.651.705.500]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Subunits [D12.776.377.715.548.705]
Immunoglobulin Heavy Chains [D12.776.377.715.548.705.500]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Heavy Chains".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1994	0	1	1
1995	1	0	1
1996	1	1	2
1998	0	1	1
1999	1	0	1
2002	0	1	1
2004	1	0	1
2006	0	1	1
2009	2	0	2
2012	0	1	1
2013	2	0	2
2014	1	1	2
2015	2	1	3
2016	0	1	1

Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.

Lampson BL, Kasar SN, Matos TR, Morgan EA, Rassenti L, Davids MS, Fisher DC, Freedman AS, Jacobson CA, Armand P, Abramson JS, Arnason JE, Kipps TJ, Fein J, Fernandes S, Hanna J, Ritz J, Kim HT, Brown JR. Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Blood. 2016 07 14; 128(2):195-203.

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Rounds WH, Salinas EA, Wilks TB, Levin MK, Ligocki AJ, Ionete C, Pardo CA, Vernino S, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL. MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing. Gene. 2015 Nov 10; 572(2):191-7.

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Mongini PK, Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, Allen SL, Rai K, Chu CC, Chiorazzi N. TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells. J Immunol. 2015 Aug 01; 195(3):901-23.

View in: PubMed
Stavnezer J, Schrader CE. Response to comment on "IgH chain class switch recombination: mechanism and regulation". J Immunol. 2015 Mar 01; 194(5):2040.

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Stavnezer J, Schrader CE. IgH chain class switch recombination: mechanism and regulation. J Immunol. 2014 Dec 01; 193(11):5370-8.

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Lu DR, Tan YC, Kongpachith S, Cai X, Stein EA, Lindstrom TM, Sokolove J, Robinson WH. Identifying functional anti-Staphylococcus aureus antibodies by sequencing antibody repertoires of patient plasmablasts. Clin Immunol. 2014 May-Jun; 152(1-2):77-89.

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Tan YC, Blum LK, Kongpachith S, Ju CH, Cai X, Lindstrom TM, Sokolove J, Robinson WH. High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination. Clin Immunol. 2014 Mar; 151(1):55-65.

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Casaz P, Boucher E, Wollacott R, Pierce BG, Rivera R, Sedic M, Ozturk S, Thomas WD, Wang Y. Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches. MAbs. 2014; 6(6):1533-9.

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Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-1189.

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Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475.

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