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Shailja Pathania PhD

TitleAdjunct Associate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Boston
100 William T Morrissey Blvd
Boston MA 02125-3300
Phone617-287-6398
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine


    Collapse Biography 
    Collapse education and training
    Delhi University, New Delhi, DL, IndiaBSChemistry
    Indian Institute of Technology Bombay, Mumbai, , IndiaMSBiotechnology
    University of Texas, Austin, Austin, TX, United StatesPHDMolecular Genetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Balkwill FR, Laumont CM, Burdett N, Le Saux O, Garsed DW, Grither WR, Nijhuis AM, Recouvreux MS, Kang Z, Zhang R, Chiappinelli KB, Lee JS, Laniti DD, McNeish I, Ahmed AA, Rottapel R, Conejo-Garcia JR, Odunsi K, Pharoah PDP, Zamarin D, Ishak CA, Fotopoulou C, Buckanovich RJ, Labidi-Galy I, Brenton JD, Lengyel E, Cook DP, George SHL, Lheureux S, Drapkin R, Nephew KP, Adams S, Pathania S, Nelson BH, F?rkkil? A, Fuh K, Neel BG, Bowtell DD. Rethinking ovarian cancer III: the past decade and future directions. Nat Rev Cancer. 2026 Jun; 26(6):452-471. PMID: 41975230.
      Citations:    
    2. Situ K, Duan H, Godin SK, Yang J, McCloskey GQ, Naeem B, Gillis MK, Zeb MH, Salhotra S, Rawal P, Patel N, Mouliere SK, Chen J, B?k?si A, P?link?s HL, Venkatesan S, Green AM, Birkbak NJ, V?rtessy BG, Swanton C, Pathania S. BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability. Nat Commun. 2025 Oct 29; 16(1):9544. PMID: 41162355.
      Citations:    
    3. Sipes J, Zha D, Rayamajhi S, Bantis LE, Madan R, Mitra A, Puri RV, Rahman MM, Ahmmed F, Pathak HB, Russo A, Sardiu M, Isenberg BC, Cain BP, Coppeta J, Galhenage PM, Pathania S, David SM, Burdette JE, Godwin AK. Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. Cancer Res Commun. 2025 Aug 01; 5(8):1266-1281. PMID: 40689422.
      Citations:    
    4. Li CM, Cordes A, Oliphant MUJ, Quinn SA, Thomas M, Selfors LM, Silvestri F, Girnius N, Rinaldi G, Zoeller JJ, Shapiro H, Tsiobikas C, Gupta KP, Pathania S, Regev A, Kadoch C, Muthuswamy SK, Brugge JS. Author Correction: Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer. Nat Genet. 2024 Dec; 56(12):2842. PMID: 39567749.
      Citations:    
    5. Li CM, Cordes A, Oliphant MUJ, Quinn SA, Thomas M, Selfors LM, Silvestri F, Girnius N, Rinaldi G, Zoeller JJ, Shapiro H, Tsiobikas C, Gupta KP, Pathania S, Regev A, Kadoch C, Muthuswamy SK, Brugge JS. Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer. Nat Genet. 2024 Dec; 56(12):2763-2775. PMID: 39528827.
      Citations:    
    6. Diossy M, Tisza V, Li H, Sahgal P, Zhou J, Sztupinszki Z, Young D, Nousome D, Kuo C, Jiang J, Chen Y, Ebner R, Sesterhenn IA, Moncur JT, Chesnut GT, Petrovics G, Klus GT, Valcz G, Nuzzo PV, Ribli D, B?rcs?k J, Prosz A, Krzystanek M, Ried T, Szuts D, Rizwan K, Kaochar S, Pathania S, D'Andrea AD, Csabai I, Srivastava S, Freedman ML, Dobi A, Spisak S, Szallasi Z. Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression. NPJ Precis Oncol. 2024 Sep 19; 8(1):208. PMID: 39294262.
      Citations:    
    7. Szallasi Z, Diossy M, Tisza V, Li H, Sahgal P, Zhou J, Sztupinszki Z, Young D, Nuosome D, Kuo C, Jiang J, Chen Y, Ebner R, Sesterhenn I, Moncur J, Chesnut G, Petrovics G, T Klus G, Valcz G, Nuzzo P, Ribli D, B?rcs?k J, Pr?sz A, Krzystanek M, Ried T, Sz?ts D, Rizwan K, Kaochar S, Pathania S, D'Andrea A, Csabai I, Srivastava S, Freedman M, Dobi A, Spisak S. Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency. Res Sq. 2024 Apr 01. PMID: 38645014.
      Citations:    
    8. Prosz A, Duan H, Tisza V, Sahgal P, Topka S, Klus GT, B?rcs?k J, Sztupinszki Z, Hanlon T, Diossy M, Vizkeleti L, Stormoen DR, Csabai I, Pappot H, Vijai J, Offit K, Ried T, Sethi N, Mouw KW, Spisak S, Pathania S, Szallasi Z. Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma. Sci Rep. 2023 11 23; 13(1):20567. PMID: 37996508.
      Citations:    
    9. Galhenage P, Zhou Y, Perry E, Loc B, Fietz K, Iyer S, Reinhardt F, Da Silva T, Botchkarev V, Chen J, Crum CP, Weinberg RA, Pathania S. Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer. Cell Rep. 2023 10 31; 42(10):113144. PMID: 37729060.
      Citations:    
    10. Islam KN, Ajao A, Venkataramani K, Rivera J, Pathania S, Henke K, Siegfried KR. The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish. PLoS Genet. 2023 08; 19(8):e1010589. PMID: 37552671.
      Citations:    
    11. Prosz A, Duan H, Tisza V, Sahgal P, Topka S, Klus GT, B?rcs?k J, Sztupinszki Z, Hanlon T, Diossy M, Vizkeleti L, Stormoen DR, Csabai I, Pappot H, Vijai J, Offit K, Ried T, Sethi N, Mouw KW, Spisak S, Pathania S, Szallasi Z. Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma. bioRxiv. 2023 Feb 07. PMID: 36798363.
      Citations:    
    12. Kensler KH, Baichoo S, Pathania S, Rebbeck TR. The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer. NPJ Precis Oncol. 2022 Jun 17; 6(1):39. PMID: 35715489.
      Citations:    
    13. He Y, Rivera J, Diossy M, Duan H, Bowman-Colin C, Reed R, Jennings R, Novak J, Tran SV, Cohen EF, Szuts D, Giobbie-Hurder A, Bronson RT, Bass AJ, Signoretti S, Szallasi Z, Livingston DM, Pathania S. BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34607954.
      Citations:    
    14. Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, P?rez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, P?pin D, Weinberg RA. Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Cancer Discov. 2021 02; 11(2):384-407. PMID: 33158843.
      Citations:    
    15. Duan H, Pathania S. RPA, RFWD3 and BRCA2 at stalled forks: a balancing act. Mol Cell Oncol. 2020; 7(6):1801089. PMID: 33241105.
      Citations:    
    16. Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS. Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16500-16508. PMID: 32601199.
      Citations:    
    17. Duan H, Mansour S, Reed R, Gillis MK, Parent B, Liu B, Sztupinszki Z, Birkbak N, Szallasi Z, Elia AEH, Garber JE, Pathania S. E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells. J Cell Biol. 2020 06 01; 219(6). PMID: 32391871.
      Citations:    
    18. Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. Cancer Discov. 2019 04; 9(4):526-545. PMID: 30709805.
      Citations:    
    19. Pathania S, Garber JE. Mixing Mutation Location With Carcinogen Exposure: A Recipe for Tissue Specificity in BRCA2-Associated Cancers? J Natl Cancer Inst. 2018 09 01; 110(9):925-926. PMID: 29767746.
      Citations:    
    20. Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM. BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016 07 21; 63(2):277-292. PMID: 27373334.
      Citations:    
    21. Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM. BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell. 2015 Feb 19; 57(4):636-647. PMID: 25699710.
      Citations:    
    22. Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014 Nov 17; 5:5496. PMID: 25400221.
      Citations:    
    23. Dimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev. 2013 Oct 15; 27(20):2274-91. PMID: 24142877.
      Citations:    
    24. Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51. PMID: 21963239.
      Citations:    
    25. Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D'Andrea AD, Parvin JD, Shapiro GI. Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell. 2009 Aug 14; 35(3):327-39. PMID: 19683496.
      Citations:    
    26. Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 2006 Jan 01; 20(1):34-46. PMID: 16391231.
      Citations: 182     Fields:    Translation:HumansCells
    27. Yin Z, Jayaram M, Pathania S, Harshey RM. The Mu transposase interwraps distant DNA sites within a functional transpososome in the absence of DNA supercoiling. J Biol Chem. 2005 Feb 18; 280(7):6149-56. PMID: 15563455.
      Citations:    
    28. Au TK, Pathania S, Harshey RM. True reversal of Mu integration. EMBO J. 2004 Aug 18; 23(16):3408-20. PMID: 15282550.
      Citations:    
    29. Pathania S, Jayaram M, Harshey RM. A unique right end-enhancer complex precedes synapsis of Mu ends: the enhancer is sequestered within the transpososome throughout transposition. EMBO J. 2003 Jul 15; 22(14):3725-36. PMID: 12853487.
      Citations:    
    30. Grainge I, Pathania S, Vologodskii A, Harshey RM, Jayaram M. Symmetric DNA sites are functionally asymmetric within Flp and Cre site-specific DNA recombination synapses. J Mol Biol. 2002 Jul 12; 320(3):515-27. PMID: 12096907.
      Citations:    
    31. Pathania S, Jayaram M, Harshey RM. Path of DNA within the Mu transpososome. Transposase interactions bridging two Mu ends and the enhancer trap five DNA supercoils. Cell. 2002 May 17; 109(4):425-36. PMID: 12086600.
      Citations:    
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