"Integrin alpha6beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
| Descriptor ID |
D039161
|
| MeSH Number(s) |
D12.776.543.750.705.408.460.170 D12.776.543.750.705.876.750
|
| Concept/Terms |
Integrin alpha6beta4- Integrin alpha6beta4
- alpha6beta4, Integrin
- alpha(6)beta(4) Integrin
- alpha6 beta4 Integrin
- Integrin, alpha6 beta4
- beta4 Integrin, alpha6
- Integrin alpha(6),beta(4)
- A9 Antigen
- Antigen, A9
- TSP-180
- Tumor Specific Protein-180 Complex
- Tumor Specific Protein 180 Complex
- alpha(6)beta(4) Epithelial Integrin
- Laminin-5 Receptor (alpha6beta4 Integrin)
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta4".
This graph shows the total number of publications written about "Integrin alpha6beta4" by people in this website by year, and whether "Integrin alpha6beta4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 0 | 2 |
| 2004 | 3 | 0 | 3 |
| 2005 | 3 | 1 | 4 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha6beta4" by people in Profiles.
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Brown CW, Amante JJ, Mercurio AM. Cell clustering mediated by the adhesion protein PVRL4 is necessary for a6?4 integrin-promoted ferroptosis resistance in matrix-detached cells. J Biol Chem. 2018 08 17; 293(33):12741-12748.
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Brown CW, Amante JJ, Goel HL, Mercurio AM. The a6?4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017 12 04; 216(12):4287-4297.
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Yang X, Dutta U, Shaw LM. SHP2 mediates the localized activation of Fyn downstream of the a6?4 integrin to promote carcinoma invasion. Mol Cell Biol. 2010 Nov; 30(22):5306-17.
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Kim TH, Kim HI, Soung YH, Shaw LA, Chung J. Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion. Mol Cancer Res. 2009 Oct; 7(10):1605-12.
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Dutta U, Shaw LM. A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression. Cancer Res. 2008 Nov 01; 68(21):8779-87.
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Folgiero V, Bachelder RE, Bon G, Sacchi A, Falcioni R, Mercurio AM. The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. Cancer Res. 2007 Feb 15; 67(4):1645-52.
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Yoon SO, Shin S, Mercurio AM. Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res. 2006 Jun 15; 66(12):6288-95.
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Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS, Mercurio AM. The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res. 2005 Dec 01; 65(23):10970-6.
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Mercurio AM, Lipscomb EA, Bachelder RE. Non-angiogenic functions of VEGF in breast cancer. J Mammary Gland Biol Neoplasia. 2005 Oct; 10(4):283-90.
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Lipscomb EA, Mercurio AM. Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 2005 Sep; 24(3):413-23.