"Integrin beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.
| Descriptor ID |
D039663
|
| MeSH Number(s) |
D12.776.543.750.705.408.200.800
|
| Concept/Terms |
Integrin beta4- Integrin beta4
- beta4, Integrin
- beta4 Integrin
- Integrin, beta4
- CD104 Antigens
- Antigens, CD104
- CD104 Antigen
- Antigen, CD104
- Integrin beta(4)
|
Below are MeSH descriptors whose meaning is more general than "Integrin beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin beta4".
This graph shows the total number of publications written about "Integrin beta4" by people in this website by year, and whether "Integrin beta4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin beta4" by people in Profiles.
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Goel HL, Karner ER, Kumar A, Mukhopadhyay D, Goel S, Mercurio AM. YAP/TAZ-mediated regulation of laminin 332 is enabled by ?4 integrin repression of ZEB1 to promote ferroptosis resistance. J Biol Chem. 2024 04; 300(4):107202.
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Wang M, Xiong C, Mercurio AM. PD-LI promotes rear retraction during persistent cell migration by altering integrin ?4 dynamics. J Cell Biol. 2022 05 02; 221(5).
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Walker MR, Amante JJ, Li J, Liu H, Zhu LJ, Feltri ML, Goel HL, Mercurio AM. Alveolar progenitor cells in the mammary gland are dependent on the ?4 integrin. Dev Biol. 2020 01 01; 457(1):13-19.
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Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 07 31; 132(15).
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Li J, Sun H, Feltri ML, Mercurio AM. Integrin ?4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15; 407(2):313-20.
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Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38a MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 02; 290(1):284-95.
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Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ?4. FASEB J. 2015 Jan; 29(1):131-40.
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Chang C, Yang X, Pursell B, Mercurio AM. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4. Mol Cell Biol. 2013 Oct; 33(19):3795-804.
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Wang L, Pawlak EA, Johnson PJ, Belknap JK, Eades S, Stack S, Cousin H, Black SJ. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One. 2013; 8(2):e56025.
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Gerson KD, Shearstone JR, Maddula VSRK, Seligmann BE, Mercurio AM. Integrin ?4 regulates SPARC protein to promote invasion. J Biol Chem. 2012 Mar 23; 287(13):9835-9844.