Immunoglobulin Class Switching

"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

Descriptor ID	D017578
MeSH Number(s)	G05.344.401.501.450 G12.500.274.501.450
Concept/Terms	Immunoglobulin Class Switching Immunoglobulin Class Switching Class Switching, Immunoglobulin Class Switchings, Immunoglobulin Immunoglobulin Class Switchings Switching, Immunoglobulin Class Switchings, Immunoglobulin Class Class Switching Class Switchings Switching, Class Switchings, Class Isotype Switching Isotype Switchings Switching, Isotype Switchings, Isotype

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Rearrangement [G05.344]
Gene Rearrangement, B-Lymphocyte [G05.344.401]
Gene Rearrangement, B-Lymphocyte, Heavy Chain [G05.344.401.501]
Immunoglobulin Class Switching [G05.344.401.501.450]
Immune System Phenomena [G12]
Immunogenetic Phenomena [G12.500]
Gene Rearrangement, B-Lymphocyte [G12.500.274]
Gene Rearrangement, B-Lymphocyte, Heavy Chain [G12.500.274.501]
Immunoglobulin Class Switching [G12.500.274.501.450]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Class Switching".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.

Bar chart showing 55 publications over 24 distinct years, with a maximum of 5 publications in 2004 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	2	0	2
1998	1	1	2
1999	2	0	2
2001	0	1	1
2002	2	0	2
2003	3	0	3
2004	4	1	5
2005	2	0	2
2006	2	2	4
2007	4	1	5
2008	2	0	2
2009	3	0	3
2010	3	0	3
2011	1	2	3
2012	2	0	2
2013	1	1	2
2014	2	1	3
2015	2	0	2
2016	2	0	2
2017	0	1	1
2019	0	1	1
2023	0	1	1
2025	1	0	1

Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.

Perugino CA, Liu H, Feldman J, Marbourg J, Guy TV, Hui A, Ingram N, Liebaert J, Chaudhary N, Tao W, Jacob-Dolan C, Hauser BM, Mian Z, Nathan A, Zhao Z, Kaseke C, Tano-Menka R, Getz MA, Senjobe F, Berrios C, Ofoman O, Manickas-Hill Z, Wesemann DR, Lemieux JE, Goldberg MB, N?ndel K, Moormann A, Marshak-Rothstein A, Larocque RC, Ryan ET, Iafrate JA, Lingwood D, Gaiha G, Charles R, Balazs AB, Pandit A, Naranbhai V, Schmidt AG, Pillai S. Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection. Cell Rep. 2025 Apr 22; 44(4):115472.

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Schrader CE, Williams T, Pechhold K, Linehan EK, Tsuchimoto D, Nakabeppu Y. APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. J Immunol. 2023 06 01; 210(11):1804-1814.

View in: PubMed
Leng Y, Romero R, Xu Y, Galaz J, Slutsky R, Arenas-Hernandez M, Garcia-Flores V, Motomura K, Hassan SS, Reboldi A, Gomez-Lopez N. Are B cells altered in the decidua of women with preterm or term labor? Am J Reprod Immunol. 2019 05; 81(5):e13102.

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Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. 2017 06 01; 198(11):4255-4267.

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Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9816-21.

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Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.

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Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J. Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS One. 2015; 10(8):e0134397.

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Stavnezer J, Schrader CE. Response to comment on "IgH chain class switch recombination: mechanism and regulation". J Immunol. 2015 Mar 01; 194(5):2040.

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Stavnezer J, Schrader CE. IgH chain class switch recombination: mechanism and regulation. J Immunol. 2014 Dec 01; 193(11):5370-8.

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Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. J Immunol. 2014 Jul 15; 193(2):931-9.

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