 Immunoglobulin Class Switching
"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
| Descriptor ID |
D017578
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| MeSH Number(s) |
G05.355.330.401.501.450 G12.425.742.500.501.450 G12.500.349.500.501.450
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| Concept/Terms |
Immunoglobulin Class Switching- Immunoglobulin Class Switching
- Class Switching, Immunoglobulin
- Class Switchings, Immunoglobulin
- Immunoglobulin Class Switchings
- Switching, Immunoglobulin Class
- Switchings, Immunoglobulin Class
- Class Switching
- Class Switchings
- Switching, Class
- Switchings, Class
- Isotype Switching
- Isotype Switchings
- Switching, Isotype
- Switchings, Isotype
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".
This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1998 | 1 | 1 | 2 | | 1999 | 2 | 0 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 2 | 0 | 2 | | 2003 | 3 | 0 | 3 | | 2004 | 4 | 1 | 5 | | 2005 | 2 | 0 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 4 | 1 | 5 | | 2008 | 2 | 0 | 2 | | 2009 | 3 | 1 | 4 | | 2010 | 3 | 0 | 3 | | 2011 | 1 | 2 | 3 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 2 | 1 | 3 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.
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Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.
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Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J. Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS One. 2015; 10(8):e0134397.
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Stavnezer J, Schrader CE. Response to comment on "IgH chain class switch recombination: mechanism and regulation". J Immunol. 2015 Mar 1; 194(5):2040.
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Stavnezer J, Schrader CE. IgH chain class switch recombination: mechanism and regulation. J Immunol. 2014 Dec 1; 193(11):5370-8.
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Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. J Immunol. 2014 Jul 15; 193(2):931-9.
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Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014 Mar 15; 192(6):2651-8.
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Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-9.
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Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J. DNA polymerases ß and ? do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst). 2013 Dec; 12(12):1087-93.
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Hasham MG, Snow KJ, Donghia NM, Branca JA, Lessard MD, Stavnezer J, Shopland LS, Mills KD. Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. J Immunol. 2012 Sep 1; 189(5):2374-82.
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Ucher AJ, Linehan EK, Teebor GW, Schrader CE, Stavnezer J. The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells. PLoS One. 2012; 7(4):e36061.
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