"Semaphorin-3A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
| Descriptor ID |
D040121
|
| MeSH Number(s) |
D12.644.276.923.374 D12.776.467.923.374 D23.529.923.374
|
| Concept/Terms |
Semaphorin-3A- Semaphorin-3A
- Sem D
- Semaphorin D
- Collapsin-1
- Collapsin 1
- Sema3A
- Semaphorin 3A
- Collapsing Factor
- Collapsin
|
Below are MeSH descriptors whose meaning is more general than "Semaphorin-3A".
Below are MeSH descriptors whose meaning is more specific than "Semaphorin-3A".
This graph shows the total number of publications written about "Semaphorin-3A" by people in this website by year, and whether "Semaphorin-3A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Semaphorin-3A" by people in Profiles.
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Cagnetta R, Wong HH, Frese CK, Mallucci GR, Krijgsveld J, Holt CE. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. Mol Cell. 2019 02 07; 73(3):474-489.e5.
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Cagnetta R, Frese CK, Shigeoka T, Krijgsveld J, Holt CE. Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome. Neuron. 2018 07 11; 99(1):29-46.e4.
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Mick E, McGough J, Loo S, Doyle AE, Wozniak J, Wilens TE, Smalley S, McCracken J, Biederman J, Faraone SV. Genome-wide association study of the child behavior checklist dysregulation profile. J Am Acad Child Adolesc Psychiatry. 2011 Aug; 50(8):807-17.e8.
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Schwarting GA, Raitcheva D, Crandall JE, Burkhardt C, P?schel AW. Semaphorin 3A-mediated axon guidance regulates convergence and targeting of P2 odorant receptor axons. Eur J Neurosci. 2004 Apr; 19(7):1800-10.
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Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ, Mercurio AM. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res. 2003 Sep 01; 63(17):5230-3.
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Crandall JE, Dibble C, Butler D, Pays L, Ahmad N, Kostek C, P?schel AW, Schwarting GA. Patterning of olfactory sensory connections is mediated by extracellular matrix proteins in the nerve layer of the olfactory bulb. J Neurobiol. 2000 Dec; 45(4):195-206.
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Schwarting GA, Kostek C, Ahmad N, Dibble C, Pays L, P?schel AW. Semaphorin 3A is required for guidance of olfactory axons in mice. J Neurosci. 2000 Oct 15; 20(20):7691-7.