 DNA-Directed RNA Polymerases
"DNA-Directed RNA Polymerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
| Descriptor ID |
D012321
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| MeSH Number(s) |
D08.811.913.696.445.735.270
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| Concept/Terms |
DNA-Directed RNA Polymerases- DNA-Directed RNA Polymerases
- DNA Directed RNA Polymerases
- Polymerases, DNA-Directed RNA
- RNA Polymerases, DNA-Directed
- RNA Polymerase
- Polymerase, RNA
- Transcriptases
- DNA-Directed RNA Polymerase
- DNA Directed RNA Polymerase
- Polymerase, DNA-Directed RNA
- RNA Polymerase, DNA-Directed
- DNA-Dependent RNA Polymerases
- DNA Dependent RNA Polymerases
- Polymerases, DNA-Dependent RNA
- RNA Polymerases, DNA-Dependent
- RNA Polymerases
- Polymerases, RNA
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Below are MeSH descriptors whose meaning is more general than "DNA-Directed RNA Polymerases".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed RNA Polymerases".
This graph shows the total number of publications written about "DNA-Directed RNA Polymerases" by people in this website by year, and whether "DNA-Directed RNA Polymerases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1989 | 0 | 1 | 1 | | 1995 | 0 | 2 | 2 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 3 | 0 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 4 | 0 | 4 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 0 | 2 | | 2007 | 3 | 2 | 5 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 2 | 3 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA-Directed RNA Polymerases" by people in Profiles.
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Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. Structure of RNA polymerase bound to ribosomal 30S subunit. Elife. 2017 10 13; 6.
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Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327.
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Jones DL, Brewster RC, Phillips R. Promoter architecture dictates cell-to-cell variability in gene expression. Science. 2014 Dec 19; 346(6216):1533-6.
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Weinert FM, Brewster RC, Rydenfelt M, Phillips R, Kegel WK. Scaling of gene expression with transcription-factor fugacity. Phys Rev Lett. 2014 Dec 19; 113(25):258101.
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Martin CT, Theis K. Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase. Nat Struct Mol Biol. 2014 Sep; 21(9):741-2.
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Samanta S, Martin CT. Insights into the mechanism of initial transcription in Escherichia coli RNA polymerase. J Biol Chem. 2013 Nov 01; 288(44):31993-2003.
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Brewster RC, Jones DL, Phillips R. Tuning promoter strength through RNA polymerase binding site design in Escherichia coli. PLoS Comput Biol. 2012; 8(12):e1002811.
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RamÃrez-Tapia LE, Martin CT. New insights into the mechanism of initial transcription: the T7 RNA polymerase mutant P266L transitions to elongation at longer RNA lengths than wild type. J Biol Chem. 2012 Oct 26; 287(44):37352-61.
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Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH, Surovtseva YV, Shadel GS, Cooper MP. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem. 2011 Dec 02; 286(48):41253-64.
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Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, Chakraborty A, Druzhinin SY, Chatterjee S, Mukhopadhyay J, Ebright YW, Zozula A, Shen J, Sengupta S, Niedfeldt RR, Xin C, Kaneko T, Irschik H, Jansen R, Donadio S, Connell N, Ebright RH. New target for inhibition of bacterial RNA polymerase: 'switch region'. Curr Opin Microbiol. 2011 Oct; 14(5):532-43.
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