DNA-Directed RNA Polymerases

"DNA-Directed RNA Polymerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).

Descriptor ID	D012321
MeSH Number(s)	D08.811.913.696.445.735.270
Concept/Terms	DNA-Directed RNA Polymerases DNA-Directed RNA Polymerases DNA Directed RNA Polymerases Polymerases, DNA-Directed RNA RNA Polymerases, DNA-Directed RNA Polymerase Polymerase, RNA Transcriptases DNA-Directed RNA Polymerase DNA Directed RNA Polymerase Polymerase, DNA-Directed RNA RNA Polymerase, DNA-Directed DNA-Dependent RNA Polymerases DNA Dependent RNA Polymerases Polymerases, DNA-Dependent RNA RNA Polymerases, DNA-Dependent RNA Polymerases Polymerases, RNA Transcriptase Transcriptase

Below are MeSH descriptors whose meaning is more general than "DNA-Directed RNA Polymerases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
RNA Nucleotidyltransferases [D08.811.913.696.445.735]
DNA-Directed RNA Polymerases [D08.811.913.696.445.735.270]

Below are MeSH descriptors whose meaning is related to "DNA-Directed RNA Polymerases".

Below are MeSH descriptors whose meaning is more specific than "DNA-Directed RNA Polymerases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Directed RNA Polymerases" by people in this website by year, and whether "DNA-Directed RNA Polymerases" was a major or minor topic of these publications.

Bar chart showing 49 publications over 24 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	0	1	1
2001	3	0	3
2002	1	0	1
2003	0	2	2
2004	4	0	4
2005	1	2	3
2006	2	0	2
2007	3	2	5
2009	1	1	2
2010	0	1	1
2011	0	1	1
2012	2	0	2
2013	1	0	1
2014	1	2	3
2015	1	0	1
2017	1	0	1
2018	1	0	1
2019	2	0	2
2020	1	1	2
2021	3	1	4
2022	1	0	1
2023	0	2	2
2024	1	1	2

Below are the most recent publications written about "DNA-Directed RNA Polymerases" by people in Profiles.

MalagodaPathiranage K, Banerjee R, Martin CT. A new approach to RNA synthesis: immobilization of stably and functionally co-tethered promoter DNA and T7 RNA polymerase. Nucleic Acids Res. 2024 Sep 23; 52(17):10607-10618.

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Ali MZ, Guharajan S, Parisutham V, Brewster RC. Regulatory properties of transcription factors with diverse mechanistic function. PLoS Comput Biol. 2024 Jun; 20(6):e1012194.

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Malagoda Pathiranage K, Martin CT. A simple approach to improving RNA synthesis: Salt inhibition of RNA rebinding coupled with strengthening promoter binding by a targeted gap in the DNA. Methods Enzymol. 2023; 691:209-222.

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MalagodaPathiranage K, Cavac E, Chen TH, Roy B, Martin CT. High-salt transcription from enzymatically gapped promoters nets higher yields and purity of transcribed RNAs. Nucleic Acids Res. 2023 04 11; 51(6):e36.

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Dousis A, Ravichandran K, Hobert EM, Moore MJ, Rabideau AE. An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts. Nat Biotechnol. 2023 04; 41(4):560-568.

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Eshleman SH, Fogel JM, Piwowar-Manning E, Chau G, Cummings V, Agyei Y, Richardson P, Sullivan P, Haines CD, Bushman LR, Petropoulos C, Persaud D, Kofron R, Hendrix CW, Anderson PL, Farrior J, Mellors J, Adeyeye A, Rinehart A, St Clair M, Ford S, Rooney JF, Mathew CA, Hunidzarira P, Spooner E, Mpendo J, Nair G, Cohen MS, Hughes JP, Hosseinipour M, Hanscom B, Delany-Moretlwe S, Marzinke MA. Characterization of Human Immunodeficiency Virus (HIV) Infections in Women Who Received Injectable Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention: HPTN 084. J Infect Dis. 2022 05 16; 225(10):1741-1749.

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Guharajan S, Chhabra S, Parisutham V, Brewster RC. Quantifying the regulatory role of individual transcription factors in Escherichia coli. Cell Rep. 2021 11 09; 37(6):109952.

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Gopalan S, Wang Y, Harper NW, Garber M, Fazzio TG. Simultaneous profiling of multiple chromatin proteins in the same cells. Mol Cell. 2021 11 18; 81(22):4736-4746.e5.

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Labuz DF, Cunningham A, Tobias J, Dixon A, Dewey E, Marenco CW, Escobar MA, Hazeltine MD, Cleary MA, Kotagal M, Falcone RA, Fallon SC, Naik-Mathuria B, MacArthur T, Klinkner DB, Shah A, Chernoguz A, Orioles A, Zagel A, Gosain A, Knaus M, Hamilton NA, Jafri MA. Venous thromboembolic risk stratification in pediatric trauma: A Pediatric Trauma Society Research Committee multicenter analysis. J Trauma Acute Care Surg. 2021 10 01; 91(4):605-611.

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Cavac E, Ram?rez-Tapia LE, Martin CT. High-salt transcription of DNA cotethered with T7 RNA polymerase to beads generates increased yields of highly pure RNA. J Biol Chem. 2021 09; 297(3):100999.

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