Platelet Glycoprotein GPIIb-IIIa Complex

"Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

Descriptor ID	D019039
MeSH Number(s)	D12.776.395.550.625.785 D12.776.543.550.625.785 D12.776.543.750.705.408.460.700 D12.776.543.750.705.675.784
Concept/Terms	Platelet Glycoprotein GPIIb-IIIa Complex Platelet Glycoprotein GPIIb-IIIa Complex Platelet Glycoprotein GPIIb IIIa Complex Glycoproteins IIb-IIIa Glycoproteins IIb IIIa Integrin alpha-IIb beta-3 Integrin alpha IIb beta 3 beta-3, Integrin alpha-IIb Integrin alphaIIbbeta3 alphaIIbbeta3, Integrin GPIIb-IIIa Receptors GPIIb IIIa Receptors Receptors, GPIIb-IIIa

Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIIb-IIIa Complex".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Platelet Membrane Glycoproteins [D12.776.395.550.625]
Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.395.550.625.785]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Platelet Membrane Glycoproteins [D12.776.543.550.625]
Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.550.625.785]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Integrins [D12.776.543.750.705.408]
Receptors, Cytoadhesin [D12.776.543.750.705.408.460]
Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.408.460.700]
Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.675.784]

Below are MeSH descriptors whose meaning is related to "Platelet Glycoprotein GPIIb-IIIa Complex".

Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIIb-IIIa Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publications.

Bar chart showing 45 publications over 20 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	1	1	2
2001	1	1	2
2002	1	2	3
2003	3	1	4
2004	3	0	3
2005	2	2	4
2006	1	0	1
2007	1	4	5
2008	1	1	2
2010	0	2	2
2012	0	1	1
2013	1	0	1
2014	1	0	1
2015	0	4	4
2017	1	1	2
2018	0	2	2
2020	2	0	2
2021	0	2	2
2022	1	0	1

Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles.

Binder V, Chruscicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. Carbamylation of Integrin aIIb?3: The Mechanistic Link to Platelet Dysfunction in ESKD. J Am Soc Nephrol. 2022 10; 33(10):1841-1856.

View in: PubMed
Gremmel T, Michelson AD, Wadowski PP, Pultar J, Weikert C, Tscharre M, Lee S, Panzer S, Frelinger AL. Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization. Atherosclerosis. 2021 12; 339:12-19.

View in: PubMed
Revel-Vilk S, Naamad M, Frydman D, Freund MR, Dinur T, Istaiti M, Becker-Cohen M, Falk R, Broide E, Michelson AD, Frelinger AL, Zimran A. Platelet Activation and Reactivity in a Large Cohort of Patients with Gaucher Disease. Thromb Haemost. 2022 06; 122(6):951-960.

View in: PubMed
Mazzeffi M, Tanaka K, Wu YF, Zhang A, Kareddy N, Tadjou Tito E, Rock P, Michelson AD, Frelinger AL. Platelet surface GPIba, activated GPIIb-IIIa, and P-selectin levels in adult veno-arterial extracorporeal membrane oxygenation patients. Platelets. 2022 Jan 02; 33(1):116-122.

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Wang S, Sawalha K, Khan A. An Unusual Case of Drug-Induced Thrombocytopenia. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620947891.

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Blair TA, Michelson AD, Frelinger AL. Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia. Sci Rep. 2018 07 09; 8(1):10300.

View in: PubMed
Frelinger AL, Grace RF, Gerrits AJ, Carmichael SL, Forde EE, Michelson AD. Platelet Function in ITP, Independent of Platelet Count, Is Consistent Over Time and Is Associated with Both Current and Subsequent Bleeding Severity. Thromb Haemost. 2018 01; 118(1):143-151.

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Mallidi JR, Robinson P, Visintainer PF, Lotfi AS, Mulvey S, Giugliano GR. Comparison of antithrombotic agents during urgent percutaneous coronary intervention following thrombolytic therapy: A retrospective cohort study. Catheter Cardiovasc Interv. 2017 Nov 15; 90(6):898-904.

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Gerrits AJ, Jakubowski JA, Sugidachi A, Michelson AD, Frelinger AL. Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor. J Thromb Haemost. 2017 05; 15(5):858-867.

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Gremmel T, Michelson AD, Frelinger AL. In Vivo and protease-activated receptor-1-mediated platelet activation in patients presenting for cardiac catheterization. Platelets. 2016 Jun; 27(4):308-16.

View in: PubMed

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